Fabrication of alginate-based hydrogel cross-linked via horseradish peroxidase for articular cartilage engineering

Saghati, Sepideh; Khoshfetrat, Ali Baradar; Nasrabadi, Hamid Tayefi; Roshangar, Leila; Rahbarghazi‬, Reza

doi:10.1186/s13104-021-05795-2

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In crosslinking, the basic physical properties (mechanisms) and biologically inducible properties mainly rely on the precursor concentration. Saghati and colleagues ( Saghati et al, 2021 ) detect the effect of several parameters, including H 2 O 2 and HRP concentrations, on the hydrogel properties of Alg-based hydrogels via an enzymatic cross-linked procedure. They found that the physical properties of 1.2% (v/w) Alg-Ph, 5 U HRP, and 100 mM H 2 O 2 at the ratio of 1:0.54:0.54 are more appropriate for the cartilage-like structure, which has a great potential to induce cartilage regeneration.…”

Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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“…Among these products, alginate-based hydrogel wound dressings accounted for around 70% (17 types), which provide a moist wound environment and facilitate autolysis for partial and full-thickness wounds with large amounts of drainage and so forth. These hydrogels generally adopt the physical cross-linking method of calcium ion cross-linking, and give priority to ensuring that the hydrogels play a protective effect, and are mainly adapted to wounds that are not serious and have a normal healing process ( Francesko et al, 2018 ; Saghati et al, 2021 ). In addition, there are many products designed to fulfill the drug delivery function of polysaccharide hydrogels.…”

Section: Clinical Applicationmentioning

confidence: 99%

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Cui

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds etc. always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process. With the advances of technology, hydrogels dressings have been showing great potentials for the treatment of both acute wounds (e.g., burn injuries, hemorrhage, rupturing of internal organs/aorta) and chronic wounds such as diabetic foot and pressure ulcer. Particularly, in the past decade, polysaccharide-based hydrogels which are made up with abundant and reproducible natural materials that are biocompatible and biodegradable present unique features and huge flexibilities for modifications as wound dressings and are widely applicable in clinical practices. They share not only common characteristics of hydrogels such as excellent tissue adhesion, swelling, water absorption, etc., but also other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and discussed their clinical states of, aiming to provide valuable hints and references for the future development of more intelligent and multifunctional wound dressings of polysaccharide hydrogels.

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“…As a result, the gelation time can be well-controlled based on the concentration of H 2 O 2 , which is a result of the deactivation effect of horseradish peroxidase by H 2 O 2 [ 94 ].…”

Section: Applicationmentioning

confidence: 99%

Recent Studies on Hydrogels Based on H2O2-Responsive Moieties: Mechanism, Preparation and Application

Song

You

Zhang

et al. 2022

Gels

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H2O2 is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A H2O2-responsive hydrogel (H2O2-Gel) is a promising candidate for biomedical applications because of its good biocompatibility, similarity to soft biological tissues, ease of preparation, and its ability to respond to H2O2. In this study, the H2O2-responsive moieties used to fabricate H2O2-Gels were reviewed, including thioethers, disulfide bonds, selenides, diselenium bonds, diketones, boronic, and others. Next, the preparation method of H2O2-Gel was divided into two major categories according to their reaction mechanisms: either self-crosslinking or mechanisms entailing the addition of difunctional crosslinkers. Last, the applications of H2O2-Gels were emphasized, which have been viewed as desirable candidates in the fields of drug delivery, the detection of H2O2, glucose-responsive systems, ROS scavengers, tissue engineering, and cell-encapsulation.

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Fabrication of alginate-based hydrogel cross-linked via horseradish peroxidase for articular cartilage engineering

Cited by 9 publications

References 21 publications

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Recent Studies on Hydrogels Based on H2O2-Responsive Moieties: Mechanism, Preparation and Application

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