Fabrication of ascorbyl palmitate loaded poly(caprolactone)/silver nanoparticle embedded poly(vinyl alcohol) hybrid nanofibre mats as active wound dressings via dual-spinneret electrospinning

Du, Lei; Xu, Huaizhong; Li, T.; Zhang, Y.; Zou, Fengyuan

doi:10.1039/c7ra03193a

Cited by 36 publications

(17 citation statements)

References 59 publications

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“…The wound dressings should provide a suitable moisturized environment for healing by absorbing excess exudates, and killing bacteria. Very recently, Du et al employed an electrospinning setup with two spinnerets to form PCL/polyvinyl alcohol (PVA) fibrous mats with a mixture of fibers, and loaded with AgNPs for mice wound healing [181]. Hydrolytic PVA maintains a moist wound environment to promote fibroblast adhesion, while PCL provides structural stability to impart mechanical strength to the resulting mats.…”

Section: Aliphatic Polyester Nanocompositesmentioning

confidence: 99%

Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets

Liao

Tjong

2019

Nanomaterials

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Aliphatic polyesters such as poly(lactic acid) (PLA), polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) copolymers have been widely used as biomaterials for tissue engineering applications including: bone fixation devices, bone scaffolds, and wound dressings in orthopedics. However, biodegradable aliphatic polyesters are prone to bacterial infections due to the lack of antibacterial moieties in their macromolecular chains. In this respect, silver nanoparticles (AgNPs), graphene oxide (GO) sheets and AgNPs-GO hybrids can be used as reinforcing nanofillers for aliphatic polyesters in forming antimicrobial nanocomposites. However, polymeric matrix materials immobilize nanofillers to a large extent so that they cannot penetrate bacterial membrane into cytoplasm as in the case of colloidal nanoparticles or nanosheets. Accordingly, loaded GO sheets of aliphatic polyester nanocomposites have lost their antibacterial functions such as nanoknife cutting, blanket wrapping and membrane phospholipid extraction. In contrast, AgNPs fillers of polyester nanocomposites can release silver ions for destroying bacterial cells. Thus, AgNPs fillers are more effective than loaded GO sheets of polyester nanocomposiites in inhibiting bacterial infections. Aliphatic polyester nanocomposites with AgNPs and AgNPs-GO fillers are effective to kill multi-drug resistant bacteria that cause medical device-related infections.

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Section: Aliphatic Polyester Nanocompositesmentioning

confidence: 99%

Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets

Liao

Tjong

2019

Nanomaterials

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“…11 We also studied the effectiveness of PVA concentration and reductant dosage on the sizes of Ag NPs. 15 The PVA/Ag NP nanobres with different sizes of Ag NPs are shown in Fig. 10.…”

Section: Resultsmentioning

confidence: 99%

“…Polyvinyl alcohol (PVA), a well-known watersoluble polymer with good biocompatibility, has been widely used in several biomedical applications, like so contact lenses, wound dressing, and tissue engineering. [14][15][16] Therefore, in view of the excellent characteristic of PVA, we prepared monodispersed Ag NPs which were embedded into the PVA nanobres.…”

Section: Introductionmentioning

confidence: 99%

Electrospun composite nanofibre fabrics containing green reduced Ag nanoparticles as an innovative type of antimicrobial insole

et al. 2019

RSC Adv.

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“…Therefore, 5 wt% SSD-loaded co-electrospun PVA/PCL showed better antibacterial and reasonable cell proliferation and differentiation. Recently, Online et al fabricated PVA merged with monodispersed Ag NPs and PCL loaded with Ascorbyl palmitate (AP) by dual-spinneret electrospinning [95]. The NIH-3T3 fibroblast cells were seeded on the scaffold mats, and it was shown that AP inhibits the toxic effects of Ag NPs on cell proliferation.…”

Section: Biomedical Applications Of Polymer-based Electrospun Nanomentioning

confidence: 99%

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

2019

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Electrospinning has gained wide attention recently in biomedical applications. Electrospun biocompatible scaffolds are well-known for biomedical applications such as drug delivery, wound dressing, and tissue engineering applications. In this review, the synthesis of polymer-based fiber composites using an electrospinning technique is discussed. Formerly, metal particles were then deposited on the surface of electrospun fibers using sputtering technology. Key nanometals for biomedical applications including silver and copper nanoparticles are discussed throughout this review. The formulated scaffolds were found to be suitable candidates for biomedical uses such as antibacterial coatings, surface modification for improving biocompatibility, and tissue engineering. This review briefly mentions the characteristics of the nanostructures while focusing on how nanostructures hold potential for a wide range of biomedical applications.

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Fabrication of ascorbyl palmitate loaded poly(caprolactone)/silver nanoparticle embedded poly(vinyl alcohol) hybrid nanofibre mats as active wound dressings via dual-spinneret electrospinning

Abstract: AP loaded PCL/AgNP embedded PVA hybrid nanofibre mats were prepared through dual-spinneret electrospinning, which altogether contributed to wound healing.

Cited by 36 publications

References 59 publications

Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets

Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets

Electrospun composite nanofibre fabrics containing green reduced Ag nanoparticles as an innovative type of antimicrobial insole

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

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