Fabrication of bimodal open-porous poly (butylene succinate)/cellulose nanocrystals composite scaffolds for tissue engineering application

Ju, Jiajun; Gu, Zhipeng; Liu, Xianhu; Zhang, Shuidong; Peng, Xiangfang; Kuang, Tairong

doi:10.1016/j.ijbiomac.2019.10.085

Cited by 61 publications

(35 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further increase PBS mechanical properties and thermal resistance extensive studies have been done with various fillers [ 1 , 10 ]. High versatility of the PBS matrix has been proven in various advanced applications like tissue engineering [ 19 ], electrospinning [ 20 ] good electrical conductivity with carbon-based fillers [ 21 ] and even light weight foams have been prepared [ 22 ]. Bio-based fillers are often preferred over mineral-inorganic types because they have advantages like renewability, sustainability, abundance, biodegradability, low density [ 6 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Poly(butylene succinate)/Microcrystalline Cellulose/Nanofibrillated Cellulose-Based Sustainable Polymer Composites: Thermo-Mechanical and Biodegradation Studies

et al. 2020

View full text Add to dashboard Cite

Biodegradable polymer composites from renewable resources are the next-generation of wood-like materials and are crucial for the development of various industries to meet sustainability goals. Functional applications like packaging, medicine, automotive, construction and sustainable housing are just some that would greatly benefit. Some of the existing industries, like wood plastic composites, already encompass given examples but are dominated by fossil-based polymers that are unsustainable. Thus, there is a background to bring a new perspective approach for the combination of microcrystalline cellulose (MCC) and nanofibrillated cellulose (NFC) fillers in bio-based poly (butylene succinate) matrix (PBS). MCC, NFC and MCC/NFC filler total loading at 40 wt % was used to obtain more insights for wood-like composite applications. The ability to tailor the biodegradable characteristics and the mechanical properties of PBS composites is indispensable for extended applications. Five compositions have been prepared with MCC and NFC fillers using melt blending approach. Young’s modulus in tensile test mode and storage modulus at 20 °C in thermo-mechanical analysis have increased about two-fold. Thermal degradation temperature was increased by approximately 60 °C compared to MCC and NFC. Additionally, to estimate the compatibility of the components and morphology of the composite’s SEM analysis was performed for fractured surfaces. The contact angle measurements testified the developed matrix interphase. Differential scanning calorimetry evidenced the trans-crystallization of the polymer after filler incorporation; the crystallization temperature shifted to the higher temperature region. The MCC has a stronger effect on the crystallinity degree than NFC filler. PBS disintegrated under composting conditions in a period of 75 days. The NFC/MCC addition facilitated the specimens’ decomposition rate up to 60 days

show abstract

Section: Introductionmentioning

confidence: 99%

Bio-Based Poly(butylene succinate)/Microcrystalline Cellulose/Nanofibrillated Cellulose-Based Sustainable Polymer Composites: Thermo-Mechanical and Biodegradation Studies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In recent years, several approaches have been utilized to prepare PBS foams with open porous structure via sc-CO 2 foaming [8,16]. Yu [8] manufactured an open-pore structured foam by using biodegradable PBS and PLA.…”

Section: Introductionmentioning

confidence: 99%

Open porous morphology evolution in poly (butylene succinate)/chitin nanocrystal nanocomposite foams

Yin

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

In recent decades, biodegradable polymeric open-porous foams have been engaging increasing interests owing to their biodegradability, porosity and biocompatibility. In this work, biodegradable poly (butylene succinate) (PBS)/chitin nanocrystals (ChNCs) nanocomposite foams with open porous structure were successful fabricated by a solid-state batch foaming method. ChNCs were obtained from chitin by using sulfuric acid treatment and then introduced into PBS. The incorporation of ChNCs had a positive effect on the crystallization behaviors, melt viscoelasticity and thermal stability of diverse PBS specimens. Compared with the change of foaming temperature, the addition of ChNCs would cause a prominent influence on the open porous structure of diverse PBS foams. The probable explanation was that during the foaming process, the spherulites and/or ChNCs as the hard region in PBS could be served as pore wall and the amorphous area as the soft region was acted as pore, leading to open porous PBS foams. The reported strategy in this work could provide the guidelines to regulate and control open porous foams in other semi-crystalline polymer matrices.

show abstract

“…Biomaterial-based bone regeneration is an effective alternative because of the materials' intrinsic properties. The bioactive composite scaffolds are implanted to treat defected or fractured bone sites and integrated into the osteochondral system [3,4]. The limitations of auto-grafts because of donor availability issues compelled scientists to develop biocompatible composite materials for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Development of Polymeric Nanocomposite (Xyloglucan-co-Methacrylic Acid/Hydroxyapatite/SiO2) Scaffold for Bone Tissue Engineering Applications—In-Vitro Antibacterial, Cytotoxicity and Cell Culture Evaluation

et al. 2020

View full text Add to dashboard Cite

Advancement and innovation in bone regeneration, specifically polymeric composite scaffolds, are of high significance for the treatment of bone defects. Xyloglucan (XG) is a polysaccharide biopolymer having a wide variety of regenerative tissue therapeutic applications due to its biocompatibility, in-vitro degradation and cytocompatibility. Current research is focused on the fabrication of polymeric bioactive scaffolds by freeze drying method for nanocomposite materials. The nanocomposite materials have been synthesized from free radical polymerization using n-SiO2 and n-HAp XG and Methacrylic acid (MAAc). Functional group analysis, crystallinity and surface morphology were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM) techniques, respectively. These bioactive polymeric scaffolds presented interconnected and well-organized porous morphology, controlled precisely by substantial ratios of n-SiO2. The swelling analysis was also performed in different media at varying temperatures (27, 37 and 47 °C) and the mechanical behavior of the dried scaffolds is also investigated. Antibacterial activities of these scaffolds were conducted against pathogenic gram-positive and gram-negative bacteria. Besides, the biological behavior of these scaffolds was evaluated by the Neutral Red dye assay against the MC3T3-E1 cell line. The scaffolds showed interesting properties for bone tissue engineering, including porosity with substantial mechanical strength, biodegradability, biocompatibility and cytocompatibility behavior. The reported polymeric bioactive scaffolds can be aspirant biomaterials for bone tissue engineering to regenerate defecated bone.

show abstract

Fabrication of bimodal open-porous poly (butylene succinate)/cellulose nanocrystals composite scaffolds for tissue engineering application

Cited by 61 publications

References 48 publications

Bio-Based Poly(butylene succinate)/Microcrystalline Cellulose/Nanofibrillated Cellulose-Based Sustainable Polymer Composites: Thermo-Mechanical and Biodegradation Studies

Bio-Based Poly(butylene succinate)/Microcrystalline Cellulose/Nanofibrillated Cellulose-Based Sustainable Polymer Composites: Thermo-Mechanical and Biodegradation Studies

Open porous morphology evolution in poly (butylene succinate)/chitin nanocrystal nanocomposite foams

Development of Polymeric Nanocomposite (Xyloglucan-co-Methacrylic Acid/Hydroxyapatite/SiO2) Scaffold for Bone Tissue Engineering Applications—In-Vitro Antibacterial, Cytotoxicity and Cell Culture Evaluation

Contact Info

Product

Resources

About