Fabrication of Bio-Based Film Comprising Metal Oxide Nanoparticles Loaded Chitosan for Wound Dressing Applications

Abstract

In the current work, chitosan (CS)–metal oxide nanohybrid (MONH) composites are prepared via combining CS with MONH made of vanadium oxide (V2O5), ytterbium trioxide (Yb2O3), and graphene oxide (GO) to generate promising wound dressing materials using the film-casting method. The developed nanohybrid@CS was examined using techniques such as Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDX), and thermogravimetric analysis (TGA). For Yb2O3@CS, the surface morphology was shown to be a rough and porous surface with pores that ranged in size from 3.0 to 5.0 µm. For CS with Yb2O3, Yb2O3/V2O5@CS, and Yb2O3/V2O5/GO@CS, the contact angles were 72.5°, 68.2°, and 46.5°, respectively. When the nanohybrid@CS was in its hydrophilic phase, which is good for absorbing moisture and drugs, there was a notable decrease in angles that tended to rise. Additionally, the inclusion of MONH allowed the cell viability to be confirmed with an IC50 of 1997.2 g/mL and the cell growth to reach 111.3% at a concentration of 7.9 g/mL.

Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene

“…These additives include nanoparticles of silver, gold, copper, zinc oxides, titanium dioxide, hematite, and copper(I) iodide, quantum dots, etc. [31][32][33][34][35][36][37][38][39]. Melamine nanoparticles introduced into the chitosan matrix accelerate the healing of infected diabetic wounds due to the rapid absorption of anti-inflammatory cytokines and reactive oxygen species, the high concentration of which in diabetic patients prevents and impairs wound healing [40].…”

Magnesium Ortho-Vanadate/Magnesium Oxide/Graphene Oxide Embedded through Cellulose Acetate-Based Films for Wound Healing Applications

“…The three active hydroxyl groups/one molecule are dynamic in introducing cellulosic proper physicochemical features [19][20][21]. Additionally, cellulose esterification produces cellulose acetate, the most prevalent natural polysaccharide in the environment, a biodegradable thermoplastic polymer [22][23][24]. CA is a semi-synthetic, biocompatible polymer with convenient hydrophilicity, degradability, and moisture retention [25].…”