Fabrication of biphasic calcium phosphates/polycaprolactone composites by melt infiltration process

Lee, Byong‐Taek; Quang, Do Van; Youn, Min-Ho; Song, Ho‐Yeon

doi:10.1007/s10856-007-3279-z

Cited by 17 publications

(8 citation statements)

References 16 publications

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“…One way to avoid blocking the pores during polymer impregnation is to optimize the polymer infiltration process thereby preserving the porosity . Polymer coatings that have been assessed as toughening agents include poly lactic acid (PLA), poly(lactic‐co‐glycolic acid) (PLGA), poly‐ɛ‐caprolactone and polyvinyl alcohol (PVA) …”

Section: New Perspectives and Other Novel Applications To Improve Thementioning

confidence: 99%

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Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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Bone is a composite material composed of collagen and calcium phosphate (CaP) mineral. The collagen gives bone its flexibility while the inorganic material gives bone its resilience. The CaP in bone is similar in composition and structure to the mineral hydroxyapatite (HA) and is bioactive, osteoinductive and osteoconductive. Therefore synthetic versions of bone apatite (BA) have been developed to address the demand for autologous bone graft substitutes. Synthetic HA (s-HA) are stiff and strong, but brittle. These lack of physical attributes limit the use of synthetic apatites in situations where no physical loading of the apatite occurs. s-HA chemical properties differ from BA and thus change the physical and mechanical properties of the material. Consequently, s-HA is more chemically stable than BA and thus its resorption rate is slower than the rate of bone regeneration. One solution to this problem is to introduce a faster resorbing CaP, such as β-tricalcium phosphate (β-TCP), when synthesizing the material creating a biphasic (s-HA and β-TCP) formulation of calcium phosphate (BCP). The focus of this review is to introduce the major differences between BCP and biological apatites and how material scientists have overcome the inadequacies of the synthetic counterparts. Examples of BCP performance in vitro and in vivo following structural and chemical modifications are provided as well as novel ultrastructural data. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2493-2512, 2018.

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Section: New Perspectives and Other Novel Applications To Improve Thementioning

confidence: 99%

“…179 Polymer coatings that have been assessed as toughening agents include poly lactic acid (PLA), poly(lacticco-glycolic acid) (PLGA), poly-E-caprolactone and polyvinyl alcohol (PVA). 72,[180][181][182][183][184][185][186][187][188]…”

Section: Bcp For Osseointegration In Functionally Loaded Areasmentioning

confidence: 99%

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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“…A number of researchers have reported the use of polymer infiltration into bioceramic scaffolds to increase mechanical properties [35][36][37][38][39][40] . In these studies, bioceramic porous structures were immersed in molten polymer or solution to achieve infiltration of either the filaments or the entire structure.…”

Section: Discussionmentioning

confidence: 99%

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2024

IJB

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Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone with favourable biocompatibility. However, natural grade PEEK-OPTIMA has shown insufficient bioactivity and limited bone integration. Bioactive PEEK composites (e.g., PEEK/calcium phosphates or Bioglass) and porous PEEK have been used to improve bone-implant interface of PEEK-based devices, but the bioactive phase distribution or porosity control is poor. In this paper, a novel method is developed to fabricate a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the HA (bioactive phase) distribution is computer-controlled within a PEEK matrix. This novel process results in complete interconnectivity of the HA network within a composite material, representing a superior advantage over alternative forms of product. The technique combines extrusion freeforming, a type of additive manufacturing (AM), and compression moulding. Compression moulding parameters, including pressure, temperature, dwelling time, and loading method together with HA microstructure were optimized by experimentation for successful biocomposite production. PEEK/HA composites with a range of HA were produced using static pressure loading to minimise air entrapment within PEEK matrix. In addition, the technique can also be employed to produce porous PEEK structures with controlled pore size and distribution.

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“…Recently, importance has been attached to the PCL-matrix composite for load-bearing orthopedic applications [6,7], for PCL is key among biodegradable and essentially nontoxic polymer groups used in biomaterials research [8]. Recent research results indicated that the mechanical properties of HA= PCL composites were close to the regime of some cortical bones, making this composite a potential bone candidate for use in load-bearing applications [9].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and In Vitro Bioactivity of Poly (ϵ-caprolactone) Composites Filled with Silane-Modified Nano-Apatite Particles

Deng¹,

Yang²,

Weng³

2011

International Journal of Polymeric Materials

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Silane coupling agents were firstly employed to modify the surfaces of nano-apatite (n-HA) particles, and then thin films of the silanized n-HA=PCL composites were successfully developed by incorporating solvent dispersion and thermal co-blending with hot-pressing methods. In vitro studies were conducted using the 2-time simulated body fluid (2SBF). Composite specimens were soaked in 2SBF from 3 to 14. Results showed that a layer of bone-like apatite was formed within 7 days on the surfaces of all composites, after its immersion in 2SBF, demonstrating moderate in vitro bioactivity of these composites.

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Fabrication of biphasic calcium phosphates/polycaprolactone composites by melt infiltration process

Cited by 17 publications

References 16 publications

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Fabrication and In Vitro Bioactivity of Poly (ϵ-caprolactone) Composites Filled with Silane-Modified Nano-Apatite Particles

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