Fabrication of calcite blocks from gypsum blocks by compositional transformation based on dissolution–precipitation reactions in sodium carbonate solution

Ishikawa, Kunio; Kawachi, Giichiro; Tsuru, Kanji; Yoshimoto, Ayami

doi:10.1016/j.msec.2016.11.093

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…To facilitate the penetration of cells and tissues into materials, the network of channels connecting macropores should ideally not be intricate. However, in most synthetic BG materials, macropores are not entirely connected and the paths are complex because of the method used to produce the macropores, such as the removal of porogens from the compact composed of ceramic powder and porogens. − Ideally, macropores penetrate straight into the material. From this perspective, a honeycomb (HC) structure, which is an array of hollow cells formed between thin vertical walls, is ideal. − …”

Section: Introductionmentioning

confidence: 99%

Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes: Effects of Composition on Bone Formation and Maturation

Hayashi

Kishida

Tsuchiya

et al. 2020

ACS Appl. Bio Mater.

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Material composition and porous structure are important factors in the formation and maturation of newly formed bone and replacement of materials by new bone. Conventional bone graft materials often lack suitability for bone generation because of the complexity of their macroporous structures, which can interfere with the penetration of cells related to bone remodeling and angiogenesis in the materials. In the present study, carbonate apatite (CO3Ap), hydroxyapatite (HAp), and β-tricalcium phosphate (TCP) honeycomb granules (HCGs) with uniformly sized macropores (∼115 μm) were fabricated. These HCG macropores were arranged in a regular fashion and penetrated straight into the granules. They were implanted into a rabbit femur defect for further evaluation. In the CO3Ap HCG implantation group, mature bone formed within CO3Ap HCG macropores by 4 weeks after grafting, and a large portion of CO3Ap HCGs was replaced by new bone at 12 weeks. By contrast, in the β-TCP HCG implantation group, new bone was not always formed in the regions after β-TCP HCG disappearance, and immature bone was present within β-TCP HCG macropores even after 12 weeks. HAp HCGs were not resorbed, and their macropores were filled with immature bone. The area of mature bone in the CO3Ap HCG implantation group was 3.3 and 1.6 times higher at 4 weeks and 2.2 and 1.7 times higher at 12 weeks compared with the HAp and β-TCP HCG implantation groups, respectively. Furthermore, the degrees of bone maturation for CO3Ap, HAp, and β-TCP HCGs were 100, 34, and 64% at 4 weeks, and 100, 54, and 69% at 12 weeks, respectively. Thus, the composition of the HCGs affected bone formation and maturation.

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Section: Introductionmentioning

confidence: 99%

Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes: Effects of Composition on Bone Formation and Maturation

Hayashi

Kishida

Tsuchiya

et al. 2020

ACS Appl. Bio Mater.

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“…When CaSO 4 granules are immersed in an aqueous solution, they slightly dissolve and supply Ca 2+ and SO 4 2− to the solution as shown in Equation (1). When the solution contains CO 3 2− , it is supersaturated with respect to CaCO 3 and thus, the CaCO 3 precipitates, as shown in Equation (2) (Ishikawa, Kawachi, Tsuru, & Yoshimoto, ).

{CaSO}_{4} \to {Ca}^{2 +} + {SO}_{4}^{2 -}

{Ca}^{2 +} + {CO}_{3}^{2 -} \to {CaCO}_{3}

…”

Section: Discussionmentioning

confidence: 99%

“…The first is the linear shrinkage of gypsum caused by heating at 700°C to burn out the microfibers (Ishikawa, Tram, Tsuru, & Toita, ). The other cause is the precipitation of newly formed CaCO 3 and/or CO 3 Ap crystals on the surface of the created pores during the dissolution–precipitation reaction (Ishikawa et al, ; Zhao et al, ). The thickness of the precipitated CO 3 Ap is generally constant per surface area of the pore, provided that the reaction conditions are the same.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

Akita

Fukuda

Kamada

et al. 2019

J Biomedical Materials Res

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Carbonate apatite (CO 3 Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO 3 Ap granules through a twostep dissolution-precipitation reaction using CaSO 4 as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO 3 Ap. Porous CO 3 Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO 3 Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO 3 Ap (120) [porous CO 3 Ap granules made using 120-μm microfiber] followed by CO 3 Ap (50) and CO 3 Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO 3 Ap (120). It is concluded, therefore, that the optimal pore size of the CO 3 Ap is that of CO 3 Ap (120), which is 85 μm. K E Y W O R D Sbone formation, bone substitute, carbonate apatite, hydroxyapatite, optimal pore size

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“…Autologous bone is considered an ideal material for the treatment of large bone defects due to its retention of osteoblasts and bioactive molecules, including growth factors with osteogenic induction properties ( Cheng et al, 2018 ; Pförringer et al, 2018 ). However, there are some problems with autologous bone, such as limited donor bone and the risk of bleeding and infection during collection ( Ishikawa et al, 2017 ; Lee et al, 2020 ). Allografts can also be used to treat bone defects to compensate for the limitations of autografts, but carry the risk of immune rejection ( Lai et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

Liu

Zhao

et al. 2022

Front. Bioeng. Biotechnol.

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Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical and unsatisfactory biological properties of PLGA limit further application in bone tissue engineering. Calcium sulfate (CaSO4) is one of the most promising bone repair materials due to its non-immunogenicity, well biocompatibility, and excellent bone conductivity. In this study, aiming at the shortcomings of activity-lack and low mechanical of PLGA in bone tissue engineering, customized-designed 3D porous PLGA/CaSO4 scaffolds were prepared by 3D printing. We first studied the physical properties of PLGA/CaSO4 scaffolds and the results showed that CaSO4 improved the mechanical properties of PLGA scaffolds. In vitro experiments showed that PLGA/CaSO4 scaffold exhibited good biocompatibility. Moreover, the addition of CaSO4 could significantly improve the migration and osteogenic differentiation of MC3T3-E1 cells in the PLGA/CaSO4 scaffolds, and the PLGA/CaSO4 scaffolds made with 20 wt.% CaSO4 exhibited the best osteogenesis properties. Therefore, calcium sulfate was added to PLGA could lead to customized 3D printed scaffolds for enhanced mechanical properties and biological properties. The customized 3D-printed PLGA/CaSO4 scaffold shows great potential for precisely repairing irregular load-bearing bone defects.

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Fabrication of calcite blocks from gypsum blocks by compositional transformation based on dissolution–precipitation reactions in sodium carbonate solution

Cited by 8 publications

References 33 publications

Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes: Effects of Composition on Bone Formation and Maturation

Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes: Effects of Composition on Bone Formation and Maturation

Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

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