Fabrication of coated polymer microneedles for transdermal drug delivery

Yang, Chen; Chen, Bo Zhi; Wang, Qi Lei; Xu, Jin; Guo, Xin Dong

doi:10.1016/j.jconrel.2017.03.383

Cited by 170 publications

(84 citation statements)

References 40 publications

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“…Therefore, localized delivery of water‐insoluble drugs with tissue penetrating MNs is an attractive strategy. Current designs of MN for delivery of water insoluble drugs often incorporate synthetic polymers with high hydrophobicity, such as polylactic acid to enhance drug loading capacity, [ 34 ] or embedding secondary nanocarriers to indirectly load water insoluble drugs. Compared with synthetic polymer‐based MN patch, GelMA resembles native ECM with high biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Biodegradableβ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

Zhou

Luo

Baidya

et al. 2020

Adv Healthcare Materials

116

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Transdermal delivery of water‐insoluble drugs via hydrogel‐based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water‐insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β‐cyclodextrin (GelMA‐β‐CD) is reported. When curcumin, an unstable and water‐insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer‐drug complex GelMA‐β‐CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three‐dimensional B16F10 melanoma models. The GelMA‐β‐CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA‐β‐CD MN arrays patch.

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Section: Discussionmentioning

confidence: 99%

Biodegradableβ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

Zhou

Luo

Baidya

et al. 2020

Adv Healthcare Materials

116

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“…Since the coating layer reduces the mechanical strength and sharpness of the needles, the drug loading on the needle surface is limited to a low amount. As a consequence, coated MNs are only usable for some specific applications in which a low dose is needed [80,81]. Human growth hormone ormone-coated titanium MNs showed a bioavailability similar to that of subcutaneous injections [82].…”

Section: Coated Mnsmentioning

confidence: 99%

Progress in Microneedle-Mediated Protein Delivery

Jamaledin

Natale

Onesto

et al. 2020

JCM

102

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The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

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“…The results of the study showed prolonged physical stability and have shown to increase the bioavailability of curcumin after oral administration, where the role of biopolymer coating have proved to be quite promising. In a recent study done by Chen et al [42] to replace hypodermic needles, for transdermal drug delivery, coated polymer microneedles could deliver drugs to subcutaneous tissues after being inserted into the skin. Interestingly, the drug delivery efficiencies of these microneedles were approximately 90% with successful penetration of the skin and could deliver the coated drug continuously.…”

Section: Biopolymer Coatingmentioning

confidence: 99%

Biopolymers and Their Composites for Drug Delivery: A Brief Review

Gopi

Amalraj²,

Sukumaran³

et al. 2018

Macromolecular Symposia

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In recent years, excipient development has become a core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Polymeric drug delivery systems have been of great interest for controlled delivery as they show the great advantage in drug delivery systems because of optimized drug loading and releasing property. Then, the side effects of synthetic polymers far exceed that it leads to some difficulties like they impose dose reduction, treatment delay, or the given therapy is not continuous. With this in mind and together with the need for a protective delivery system for drugs, natural polymeric substances such as biopolymers and their composites are the choice of research as excipient because of their low toxicity, biodegradability, stability, and renewable nature. Furthermore, they have a wide variety of structures, different physiological functions and may provide a variety of biomedical applications, owing to their distinctive properties. The present brief review explores the concept of excipient delivery and the recent advances in both the biopolymers and the methods in the pharmaceutical drug delivery systems.

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Fabrication of coated polymer microneedles for transdermal drug delivery

Cited by 170 publications

References 40 publications

Biodegradableβ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

Biodegradableβ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

Progress in Microneedle-Mediated Protein Delivery

Biopolymers and Their Composites for Drug Delivery: A Brief Review

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