Fabrication of conductive hybrid scaffold based on polyaniline/polyvinyl alcohol–chitosan nanoparticles for skin tissue engineering application

Switha, D.; Basha, Sakeenabi; Kumari, V. Sugantha

doi:10.1007/s00289-022-04616-1

Cited by 6 publications

(5 citation statements)

References 63 publications

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“…Khadija Khaldoun 1 • Sumera Khizar 2 • Salima Saidi-Besbes 1 • Nadia Zine 2 • Abdelhamid Errachid 2 • Abdelhamid Elaissari 2…”

Section: Data Availability Not Applicableunclassified

“…Recently, nanotechnology has evolved as a promptly emerging field along with plentiful biomedical applications. Nanoparticles are established with exclusive characteristics that create them desired in biology and materials science [1][2][3][4]. Amongst numerous nanoparticles, AgNPs (silver nanoparticles) are most common for investigating in current decades.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of silver nanoparticles as an antimicrobial mediator

Khaldoun,

Khizar,

Saidi-Besbes

et al. 2024

J.Umm Al-Qura Univ. Appll. Sci.

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Silver nanoparticles (AgNPs) become a topic of great research on account of their exemplary properties (optical, electrical, and antimicrobial properties). They have been executed as an exceptional antimicrobial agent having ability to combat microorganism’s in vivo and in vitro causing infections. The antibacterial activity of AgNPs covers Gram-positive and Gram-negative bacteria, as well as multidrug resistant (MDR) strains. AgNPs display manifold and immediate mechanisms of activity and in incorporation with antimicrobial agents as antibiotics or organic compounds, it exhibit synergistic impact against pathogens bacteria. The properties of AgNPs make them appropriate for their usage in healthcare and medical products where they might treat infections or inhibit them competently. A range of approaches to synthesize AgNPs are stated in literature; including physical, biological, and chemical techniques, with a growing need to establish eco-friendly processes. With the imperative need for novel and effective antimicrobial agents, this review intends to establish aspects affecting antimicrobial impacts of AgNPs, as well as to descript the benefits of employing AgNPs as new antimicrobial in different life science applications. This review summarizes synthesis of AgNPs and remarkable implementation of AgNPs dealing with their antimicrobic properties in the field of textile, food industry, agriculture, water treatment, and most importantly in health care sector. Additionally fundamental mechanism by which they implement their antimicrobic activity will also be addressed. Graphical abstract

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“…Khadija Khaldoun 1 • Sumera Khizar 2 • Salima Saidi-Besbes 1 • Nadia Zine 2 • Abdelhamid Errachid 2 • Abdelhamid Elaissari 2…”

Section: Data Availability Not Applicableunclassified

Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles as an antimicrobial mediator

Khaldoun,

Khizar,

Saidi-Besbes

et al. 2024

J.Umm Al-Qura Univ. Appll. Sci.

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“…[260] PVA/polyaniline/chitosan Conductive hybrid scaffold based on nanoparticles. Films fabricated by solution casting enhanced in vitro antibacterial properties against gram-positive (E. faecalis, S. aureus) and gram-negative (E. coli, S. typhi), and in vitro hemolytic assay value less than 2% applicable for skin repair [261] Poly ether ether ketone (PEEK) with resveratrol Electrospun two-dimensional (2D) nanofibrous scaffolds Improved antibacterial and antifungal activity using Gram-positive S. aureus and S. faecalis, gram-negative E. coli and P. aeruginosa and C. albicans as fungal strain. Enhanced in vitro biocompatibility: adhesion and proliferation using skin keratinocyte (HaCaT) and in vivo wound healing using female Wistar rats [262] Table 1.…”

Section: Electrospun Nano Hybrid Scaffoldsmentioning

confidence: 99%

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Elango,

Zamora-Ledezma,

Maté-Sánchez de Val

2023

J. Compos. Sci.

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Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is the use of polymer-based systems due to their excellent beneficial properties to the skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin and fibroin, have been tested and have proven the benefits for skin regeneration, and most of them are derived from either polysaccharide- or protein-based materials. In order to understand the mode of action, several researchers investigated the cell–matrix interaction and possible signaling mechanism in skin regeneration. Not only the signaling mechanism but also the mode of cell communication determines the application of polysaccharide- and protein-based polymers in practice. Based on the above significance, this review disclosed the recent findings to compile a possible method of communication between cells and polymers derived from polysaccharide-based (such as cellulose, hyaluronan, chitosan, alginate, agar, and xanthan gum) and protein-based (such as collagen, gelatin, fibrin, and silk fibroin) materials along with other polymers, such as poly(vinyl alcohol), polyglycolide or poly(glycolic acid), or poly(lactic acid) in skin regeneration. Accordingly, this review addresses the fundamental concept of cell–matrix communication, which helps us to understand the basis of the polymer’s functions in the biomedical field.

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“…In addition, blending or grafting of PANI onto this polymer lead to a biocompatible polymeric material with proper mechanical properties. [32][33][34] Some electrically conductive nanofibrous scaffolds have developed for STE based on PANI. A series of PANI/ chitosan nanofibers with different PANI content (1:3, 3:5, and 1:1) were fabricated by Moutsatsou et al, using electrospinning method for STE.…”

Section: Introductionmentioning

confidence: 99%

“…In this assay, poly(vinyl alcohol) (PVA) was used as a suitable hydrophilic, biocompatible, and biodegradable polymer for more biocompatibilization of PANI. In addition, blending or grafting of PANI onto this polymer lead to a biocompatible polymeric material with proper mechanical properties 32–34 …”

Section: Introductionmentioning

confidence: 99%

Nanofibrous electroconductive scaffolds composed of poly(vinyl alcohol) and modified polyaniline for skin tissue engineering application

Javid,

Eskandani,

Jaymand

et al. 2024

J of Applied Polymer Sci

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Nanofibrous electroconductive scaffolds were designed and fabricated using electrospinning approach based on a poly(vinyl alcohol)‐grafted polyaniline (PVA‐g‐PANI) and neat PVA with various PVA‐g‐PANI content for skin tissue engineering (STE) application. At first, phenylamine‐functionalized PVA macromonomer was synthesized, and then aniline was grafted onto macromonomer by an oxidation polymerization technique. The resultant PVA‐g‐PANI with different ratios was co‐electrospun with PVA to afford PVA‐g‐PANI/PVA electrically conductive nanofibrous scaffolds. Physicochemical features of the scaffolds, including water uptake properties, surface wettabilities, and morphologies as well as biological properties such as biodegradabilities, cytocompatibilities, cells adhesion and proliferation potentials, hemolysis rates, and protein adsorption capacities were investigated. Surface wettabilities of the scaffolds were altered from 55.7° for pure PVA up to 105.1° for the scaffold with the highest PVA‐g‐PANI content (30 wt%). It was found that the biodegradation rates of the scaffolds were decreased by increasing PVA‐g‐PANI content owing to very low biodegradation nature of PANI. Hemolysis assay revealed that all scaffolds were nonhemolytic (hemolysis rate <2%), except the scaffold that fabricated with 30 wt% of PVA‐g‐PANI. As results, the constructed scaffolds with 15 and 20 wt% of PVA‐g‐PANI (S3 and S4, respectively) exhibited higher potentials in both physicochemical and biological properties for STE application.

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Fabrication of conductive hybrid scaffold based on polyaniline/polyvinyl alcohol–chitosan nanoparticles for skin tissue engineering application

Cited by 6 publications

References 63 publications

Synthesis of silver nanoparticles as an antimicrobial mediator

Synthesis of silver nanoparticles as an antimicrobial mediator

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Nanofibrous electroconductive scaffolds composed of poly(vinyl alcohol) and modified polyaniline for skin tissue engineering application

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