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In this study, we aimed to fabricate nanostarch (NS) reinforced polyaniline/polyvinyl alcohol (PANI-PVA) bionanocomposite of polyaniline-polyvinyl alcohol-nanostarch for skin tissue engineering application. The microstructure of the bionanocomposite was analyzed using TEM and the particle size ranged from 35 to 37 nm. The swelling degree was increased with the increase in the concentration of nanostarch and displayed a greater hydrophilic surface leading to the increase in the absorption. The degradation index analysis was recorded with an increase in the weight loss of the scaffold which attributed to a strong hydrogen bond network. The bionanocomposites exhibited 70% to 82% of cytocompatibility towards L929 cells during the incubation period of day 1, day 4 and day 7. Hence, the novel bionanocomposite with the features of enhanced water-holding capacity, weight loss percentage and cytocompatibility made it suitable for the prospective use in skin tissue engineering applications. Graphical abstract