Fabrication of core–shell PLGA/PLA–pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs

Basu, Tanushree; Pal, Bonamali; Singh, Satnam

doi:10.1016/j.partic.2017.10.002

Cited by 25 publications

(7 citation statements)

References 25 publications

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“…This model has been widely and effectively used for the description of drug administration through polymeric matrices. An example, for the same type of polymer as the one discussed in this work, is the release of ramipril encapsulated in PLA and PLGA nanospheres, which was studied by Basu and coworkers [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic

et al. 2021

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Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient’s recovery period improving its efficacy. This study intends to support the use of supercritical solvent impregnation (SSI) as an efficient technique to develop polylactic acid (PLA) functionalized with ketoprofen, for use as controlled drug release devices. For this purpose, firstly, the influence of different SSI variables on the desirable swelling of the polymer structure, while avoiding their foaming, were evaluated. Then, the resulting ketoprofen loading was evaluated under different pressure/temperature conditions. It was generally found that as pressure and temperature are higher, the drug impregnation loads also increase. The maximum impregnation loads (at about 9% KET/PLA) were obtained at 200 bar and 75 °C. In vitro drug release tests of the impregnated compound were also carried out, and it was found that drug release profiles were also dependent on the specific pressure and temperature conditions used for the impregnation of each polymer filament.

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Section: Discussionmentioning

confidence: 99%

Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic

et al. 2021

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“…Regarding pure PLGA, the UV–vis absorption spectrum revealed bands at 250 nm [ 45 ], as reported in the literature. Focusing on the WZ-PLGA system, the absence of bands attributed to the WZ polymorph in the spectrum indicated the encapsulation of the PLGA shell and on the hexagonal P6₃mc surface.…”

Section: Resultsmentioning

confidence: 85%

Adsorption of Polylactic-co-Glycolic Acid on Zinc Oxide Systems: A Computational Approach to Describe Surface Phenomena

Mohebbi,

Pavoni,

Minnelli

et al. 2024

Nanomaterials

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Zinc oxide and polylactic-co-glycolic acid (ZnO-PLGA) nanocomposites are known to exhibit different biomedical applications and antibacterial activity, which could be beneficial for adding to wound dressings after different surgeries. However, possible cytotoxic effects along with various unexpected activities could reduce the use of these prominent systems. This is correlated to the property of ZnO, which exhibits different polymeric forms, in particular, wurtzite, zinc-blende, and rocksalt. In this study, we propose a computational approach based on the density functional theory to investigate the properties of ZnO-PLGA systems in detail. First, three different stable polymorphs of ZnO were considered. Subsequently, the abilities of each system to absorb the PLGA copolymer were thoroughly investigated, taking into account the modulation of electrical, optical, and mechanical properties. Significant differences between ZnO and PLGA systems have been found; in this study, we remark on the potential use of these models and the necessity to describe crucial surface aspects that might be challenging to observe with experimental approaches but which can modulate the performance of nanocomposites.

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“…It turned out that both particles with a pNIPAM shell had higher encapsulation efficiency than the conventional PLGA core (52.4%) and PLA core (47.42%). In addition, within 24 h, the PLGA-pNIPAM core-shell microparticles demonstrated a sustained releasing pattern of 86% of the model drug [47].…”

Section: Drug Deliverymentioning

confidence: 95%

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Patel

2021

Polymers

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Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.

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Fabrication of core–shell PLGA/PLA–pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs

Cited by 25 publications

References 25 publications

Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic

Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic

Adsorption of Polylactic-co-Glycolic Acid on Zinc Oxide Systems: A Computational Approach to Describe Surface Phenomena

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

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