2010
DOI: 10.1016/j.jcis.2010.05.022
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Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells

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Cited by 512 publications
(337 citation statements)
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References 51 publications
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“…It is noteworthy that, in caspase-4-deficient THP-1 cells, the NF-B pathway is markedly affected because caspase-4 was previously found to interact with TRAF-6, agreeing with the lack of pro-IL-1␤ in these cells (22). In another study, IL-1␤ production was found to be dependent on NF-B in THP-1 cells (37). Together with the fact that priming of the inflammasomes is dependent of NF-B activation and that caspase-4-deficient cells have reduced NF-B transduction, this information is in agreement with our observation on the impairment of pro-IL-1␤ in caspase-4-deficient cells.…”
Section: Discussionmentioning
confidence: 60%
“…It is noteworthy that, in caspase-4-deficient THP-1 cells, the NF-B pathway is markedly affected because caspase-4 was previously found to interact with TRAF-6, agreeing with the lack of pro-IL-1␤ in these cells (22). In another study, IL-1␤ production was found to be dependent on NF-B in THP-1 cells (37). Together with the fact that priming of the inflammasomes is dependent of NF-B activation and that caspase-4-deficient cells have reduced NF-B transduction, this information is in agreement with our observation on the impairment of pro-IL-1␤ in caspase-4-deficient cells.…”
Section: Discussionmentioning
confidence: 60%
“…Being hydrophobic in nature, it is insoluble in water but soluble in ethanol, dimethylsulfoxide, and acetone. To increase its solubility and bioavailability, attempts have been made through encapsulation in liposomes, polymeric and lipo-NPs, biodegradable microspheres, cyclodextrin, and hydrogels [29][30][31][32][33][34].…”
Section: Introductionmentioning
confidence: 99%
“…최근에는 메밀, 작약근, 장미꽃, 콩나물 자엽, 정향, 백자인, 녹차, 강황(심황, 울금), 검정콩 종피, 도라지 (길경), 동백 꽃잎 추출물 등과 같은 유용성 천연유래 항균 물질(Antimicrobial)을 전달체(Delivery System)에 담아 생리활성 및 효능을 극대화하기 위하여 나노크기 (Nano-Size)의 전달체를 만들려는 연구가 활발히 진행 되고 있다 [12][13][14][15][16][17][18][19][20][21]. 일반적으로 항균력이 높은 물질들은 피부에 자극을 주어 알레르기(Allergy)나 염증을 유발 하는 성분을 포함하고 있는 경우가 많기 때문에, 이러 한 유용성 항균 물질의 보호 및 저장 안정성 향상을 위하여 캡슐화(Encapsulation)하는 것이 가장 일반적인 방법으로 알려져 있으며 [22][23], 항균 물질을 캡슐화 함으로서 물리적 장벽을 제공해 주어 외부 환경으로부 터 보호하고 피부에 직접 닿을 시에도 자극과 독성을 감소시키거나 없앨 수 있다 [22,24].…”
Section: 서 론unclassified