Fabrication of customised scaffolds using computer‐aided design and rapid prototyping techniques

Naing, May Win; Chua, Chee Kai; Leong, Kah Fai; Wang, Y.

doi:10.1108/13552540510612938

Cited by 139 publications

(83 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The typical steps of lattice design in biological tissue engineering and fabrication are described in [4]. A commercial BRep solid modelling system is used to generate lattices for bone implants with the selected spatial structure parametrised by pore sizes, porosity, and surface area to volume ratio.…”

Section: Regular Microstructuresmentioning

confidence: 99%

Procedural function-based modelling of volumetric microstructures

Pasko

Fryazinov

Vilbrandt³

et al. 2011

Graphical Models

120

View full text Add to dashboard Cite

We propose a new approach to modelling heterogeneous objects containing internal volumetric structures with size of details orders of magnitude smaller than the overall size of the object. The proposed function-based procedural representation provides compact, precise, and arbitrarily parametrised models of coherent microstructures, which can undergo blending, deformations, and other geometric operations, and can be directly rendered and fabricated without generating any auxiliary representations (such as polygonal meshes and voxel arrays). In particular, modelling of regular lattices and cellular microstructures as well as irregular porous media is discussed and illustrated. We also present a method to estimate parameters of the given model by fitting it to microstructure data obtained with magnetic resonance imaging and other measurements of natural and artificial objects. Examples of rendering and digital fabrication of microstructure models are presented.

show abstract

Section: Regular Microstructuresmentioning

confidence: 99%

Procedural function-based modelling of volumetric microstructures

Pasko

Fryazinov

Vilbrandt³

et al. 2011

Graphical Models

120

View full text Add to dashboard Cite

show abstract

“…• Computer-aided tissue scaffold design and manufacturing [113,276], including SFF of tissue scaffolds and bioblueprint modeling [275], for 3D cell and organ printing [181,277].…”

Section: Computer-aided Tissue Engineering Techniquementioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

210

154

View full text Add to dashboard Cite

Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

show abstract

“…There are also applications of this technology to the medical industry. The literature features work to design truss structures to provide bone scaffold and to conform to the shape of bones from medical scans (Naing et al 2005and Challis et al 2010). This has also included creating efficient representations of stochastic cellular material that closely mimics the characteristic of bone material (Schroeder et al 2005).…”

Section: Introductionmentioning

confidence: 99%