Fabrication of Dissolvable Microneedle Patches Using an Innovative Laser-Cut Mould Design to Shortlist Potentially Transungual Delivery Systems: In Vitro Evaluation

Albarahmieh, Esra’a; AbuAmmouneh, Labiba; Kaddoura, Zaina; AbuHantash, Farah; Alkhalidi, Bashar A.; Al-Halhouli, Ala’aldeen

doi:10.1208/s12249-019-1429-5

Cited by 20 publications

(10 citation statements)

References 34 publications

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“…Additionally, this method has been used in the manufacture of hollow microneedles [214] and molds for a dissolving microneedle patch [215]. In the production of hollow microneedles, holes were created on the side of PLA sheets using a KrF laser (λ = 248 nm).…”

Section: Laser Cuttingmentioning

confidence: 99%

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Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

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Section: Laser Cuttingmentioning

confidence: 99%

“…On the other hand, Albarahmieh et al described the production of microneedle patches by employing a CO2 laser on polymethylmethacrylate (PMMA) sheets. Afterwards, a specific mixture was poured into PMMA molds, resulting in the creation of dissolvable microneedles containing methylhydroxy-4-benzoate and terbinafine hydrochloride [215].…”

Section: Laser Cuttingmentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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show abstract

“…Dissolvable MN patches are generally made of water-soluble polymers and can achieve rapid dissolution within a short time after skin insertion, thus avoiding biohazardous waste and residual drugs [42]. Dissolvable MN patches are generally made of natural polysaccharides, such as hyaluronic acid (HA) [43], dextran [44], and chitosan [45], or water-soluble polymers, such as polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) [46].…”

Section: Dissolvable Mn Patches For Sustained Release Of Hormonesmentioning

confidence: 99%

Advances in microneedle patches for long-acting contraception

Jiang

Zeng

Zhang

et al. 2023

Acta Materia Medica

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Despite the advances in contraceptives, there is still a high rate of unintended pregnancies worldwide, due in large part to the lack of effective, convenient, and safe birth control methods. Compared with short-acting contraceptives, approaches that offer long-term pregnancy protection have attracted greater interest because of the reduced dosing frequency and improved patient compliance. As a novel transdermal drug delivery system, the microneedle (MN) patch has been widely used for a variety of biomedical applications, including long-acting contraception, due to unique properties, such as painless self-administration and elimination of biohazardous waste. In this review we provide a systemic review of MN patches that have been utilized for long-term contraception, including dissolvable MN patches, polymeric biodegradable MN patches, and silk fibroin-based biodegradable MN patches. The acceptability and biosafety of these contraceptive MN patches are also discussed. Finally, we give our perspectives on the future clinical translation of MN patches for long-acting contraception.

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“…Few investigations have evaluated the feasibility of combination approaches to improve the transungual delivery of various antifungal agents [ 18 , 19 ]. Alternatively, nanovesicular drug carriers, namely liposomes, ethosomes, nanoemulsions as well as microneedle procedures, were assessed for their potential transungual drug permeation [ 20 , 21 , 22 , 23 ]. Various physical approaches, such as iontophoresis, laser technique, microporation, ablation, abrasion, and ultrasound, were also evaluated to check their prospective to enhance the drug into and through the nail [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole

et al. 2023

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The efficacy of topical antifungal therapy in onychomycosis has been hindered by the failure of the antimycotic to permeate the nail plate. This research aims to design and develop a transungual system for the effective delivery of efinaconazole utilizing constant voltage iontophoresis. Seven prototype drug-loaded hydrogel formulations (E1–E7) were prepared to assess the influence of solvent (ethanol) and cosolvent (Labrasol®) on transungual delivery. Optimization was performed to evaluate the effect of three independent variables; voltage, solvent-to-cosolvent ratio, and penetration enhancer (PEG 400) concentration on critical quality attributes (CQAs), such as drug permeation and loading into the nail. The selected hydrogel product was characterized for pharmaceutical properties, efinaconazole release from the nail, and antifungal activity. Preliminary data indicates ethanol, Labrasol®, and voltage influence the transungual delivery of efinaconazole. Optimization design indicates a significant impact by applied voltage (p-0.0001) and enhancer concentration (p-0.0004) on the CQAs. Excellent correlation between selected independent variables and CQAs was confirmed by the high desirability value (0.9427). A significant (p < 0.0001) enhancement in the permeation (~78.59 µg/cm2) and drug loading (3.24 µg/mg) was noticed in the optimized transungual delivery with 10.5 V. FTIR spectral data indicates no interaction between the drug and excipients, while the DSC thermograms confirmed the amorphous state of the drug in the formulation. Iontophoresis produces a drug depot in the nail that releases above the minimum inhibitory concentration level for an extended period, potentially reducing the need for frequent topical treatment. Antifungal studies further substantiate the release data and have shown remarkable inhibition of Trichophyton mentagrophyte. Overall, the promising results obtained here demonstrate the prospective of this non-invasive method for the effective transungual delivery of efinaconazole, which could improve the treatment of onychomycosis.

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Fabrication of Dissolvable Microneedle Patches Using an Innovative Laser-Cut Mould Design to Shortlist Potentially Transungual Delivery Systems: In Vitro Evaluation

Cited by 20 publications

References 34 publications

Microneedles Patch: Design, Fabrication and Applications

Microneedles Patch: Design, Fabrication and Applications

Advances in microneedle patches for long-acting contraception

Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole

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