Fabrication of dopamine conjugated with protein @metal organic framework for targeted drug delivery: A biocompatible pH-Responsive nanocarrier for gemcitabine release on MCF‑7 human breast cancer cells

Al-jabbar, Shatha Abd; Atiroğlu, Vesen; Hameed, Rana Majeed; Eskiler, Gamze Güney; Atiroğlu, Atheer; Özkan, Asuman Deveci; Özacar, Mahmut

doi:10.1016/j.bioorg.2021.105467

Cited by 22 publications

(13 citation statements)

References 42 publications

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“…AA has strong reducibility; thus, too much of its content can cause the solution to have an acidic pH. An acidic pH can cause the collapse of the ZIF-8 structure. , …”

Section: Resultsmentioning

confidence: 99%

“…An acidic pH can cause the collapse of the ZIF-8 structure. 38,39 In addition, the effect of the AA2P substrate and ALP on the SERS intensity was investigated. As shown in Figure 3B, the SERS intensity of PAZ NPs incubated with AA and AA2P was not significantly changed, indicating that AA and the phosphate group in AA2P cannot decompose ZIF-8 and trigger the release of PATP-Au NPs.…”

Section: Control Of Zif-8 Collapse and Patp-au Np Release By Alpmentioning

confidence: 99%

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A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Wang

Liu

et al. 2023

Anal. Chem.

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Alkaline phosphatase (ALP) is widely present in the human body and is an important biomarker. Numerous ALP detection studies have been carried out, and ascorbic acid (AA) is often used as the reducing component in the sensors to monitor ALP levels since it can be produced from ascorbic acid 2-phosphate (AA2P) hydrolysis in the presence of ALP. However, it is well-known that AA is a strong reducing agent and can be easily oxidized. The disproportion between oxidized AA and reduced AA reactions results in the generation of AA free radicals with single electrons that may lead to inaccurate results in assays. To solve this problem, we synthesized a core−shell metal−organic framework sensor (PATP-Au@ZIF-8 NP) and used it as a sensitive and accurate ALP detection sensor with self-triggered control of phosphate ions (Pi) to avoid the potential inaccuracy of the method that uses AA as the reducing component. By establishing a physical shell on the surface of the gold nanoparticles (Au NPs), the sensor not only can eliminate the random assembly of metal nanoparticles caused by plasma exposure but also can generate self-triggering of Pi caused by ALP. Pi can decompose ZIF-8 through coordination with Zn 2+ and thus can destroy the ZIF-8 shell structure of the prepared PAZ NPs. Au NPs are released and then become aggregated, in turn causing the SERS "hot spot" area to increase. The enhancement of the SERS signals was found to be directly associated with the level of Pi released from ALP-triggered hydrolysis. The response of the strategy was linear at ALP concentrations ranging from 0.1 to 150 mU/mL (r = 0.996) with a detection limit of 0.03 mU/mL. Lastly, the developed strategy was employed in the evaluation of ALP inhibitors, and the possibility to implement the developed SERS strategy for rapid and selective analysis of ALP in human serum was demonstrated.

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“…AA has strong reducibility; thus, too much of its content can cause the solution to have an acidic pH. An acidic pH can cause the collapse of the ZIF-8 structure. , …”

Section: Resultsmentioning

confidence: 99%

Section: Control Of Zif-8 Collapse and Patp-au Np Release By Alpmentioning

confidence: 99%

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Wang

Liu

et al. 2023

Anal. Chem.

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“…The characteristic peaks at 682, 1146, and 1460 cm À 1 correspond to ZIF-8 methyl and imidazole ring vibrations, Z n À N stretching, imidazole ring CÀ N stretching, and methyl bending, which proves that ZIF-8 is successfully synthesized on SiO 2 surface. [31] Figure 6(b) is the infrared spectrum of mSiO 2 @CUR before and after the mSiO 2 @ZIF-8@CUR functionalization modification. In the mSiO 2 @ZIF-8@CUR spectrum, 3356, 3053, 2927, 2361, 1508, 1184, 1200, and 893 cm À correspond to phenolic hydroxyl stretch, aromatic CÀ H stretch, aliphatic CÀ H stretch, CÀ C stretch, CÀ N stretch, CÀ O stretch, CÀ O-C stretch, and CÀ C stretch, respectively.…”

Section: Samplementioning

confidence: 99%

Corn‐like mSiO₂@ZIF‐8 Composite Load with Curcumin for Target Cancer Drug‐Delivery System

Chen

Song

et al. 2022

ChemistrySelect

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Dedication (Menglan Chen wrote the original manuscript and revised the manuscript. Fangxiang Song and Nian Wu conducted the material syntheses. Honghuan Luo and Xiaoqin Cai analyzed the experimental data. Yan Li proposed the project and provided guidance.)To improve the drug loading rate of mesoporous silica (mSiO 2 ), mSiO 2 nanorods were synthesized by a modified sol-gel method, then mSiO 2 @ZIF-8 nanoparticles were prepared by using mSiO 2 nanorods as the matrix. The structure of mSiO 2 and mSiO 2 @ZIF-8 were characterized. The results show that mSiO 2 @ZIF-8 nanoparticles are corn-like, with a specific surface area of 116.81 m 2 g À 1 , pore volume of 0.31 cm 3 g À 1 , and pore size of 8.43 nm. Curcumin (CUR) was used as an anti-tumor model drug in drug delivery experiments. The drug loading rate of mSiO 2 @ZIF-8 for CUR is 21.39 %. Before modification by Chitosan (CS) and folic acid (FA), the cumulative release rate of CUR is 30.27 % at pH 5.6 and 26.26 % at pH 7.4. After been target functionalized by CS and FA. At pH 5.6 and pH 7.4, the cumulative release rates are 34.21 % and 20.48 %, respectively, within 228 h after drug release in vitro. The results show that the drug delivery system has good pH responsiveness. Zeroorder, first-order, Higuchi, Hixson Crowell, and Korsmeyer

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“… 35 Most importantly, functional materials of BSA and GO have been widely used as platforms for loading NPs, both of which are widely used as multifunctional drug delivery vehicles. 36–40 In addition, tumor cells will rapidly ingest nano drugs by endocytosis, and then release the synthesized metal complex drugs, which not only improves the inhibitory effect of metal complex drugs on tumors, but also solves the problem of systemic drug delivery of metal complex drugs. 41–43 …”

Section: Introductionmentioning

confidence: 99%

Gallium Metal−Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells

Wu¹,

Liao²,

Niu³

et al. 2023

IJN

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Background Gallium (III) metal-organic complexes have been shown to have the ability to inhibit tumor growth, but the poor water solubility of many of the complexes precludes further application. The use of materials with high biocompatibility as drug delivery carriers for metal-organic complexes to enhance the bioavailability of the drug is a feasible approach. Methods Here, we modified the ligands of gallium 8-hydroxyquinolinate complex with good clinical anticancer activity by replacing the 8-hydroxyquinoline ligands with 5-bromo-8-hydroxyquinoline (HBrQ), and the resulting Ga(III) + HBrQ complex had poor water solubility. Two biocompatible materials, bovine serum albumin (BSA) and graphene oxide (GO), were used to synthesize the corresponding Ga(III) + HBrQ complex nanoparticles (NPs) BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs in different ways to enhance the drug delivery of the metal complex. Results Both of BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs can maintain stable existence in different solution states. In vitro cytotoxicity test showed that two nanomedicines had excellent anti-proliferation effect on HCT116 cells, which shown higher level of intracellular ROS and apoptosis ratio than that of cisplatin and oxaliplatin. In addition, the superior emissive properties of BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs allow their use for in vivo imaging showing highly effective therapy in HCT116 tumor-bearing mouse models. Conclusion The use of biocompatible materials for the preparation of NPs against poorly biocompatible metal-organic complexes to construct drug delivery systems is a promising strategy that can further improve drug delivery and therapeutic efficacy.

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Fabrication of dopamine conjugated with protein @metal organic framework for targeted drug delivery: A biocompatible pH-Responsive nanocarrier for gemcitabine release on MCF‑7 human breast cancer cells

Cited by 22 publications

References 42 publications

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Corn‐like mSiO₂@ZIF‐8 Composite Load with Curcumin for Target Cancer Drug‐Delivery System

Gallium Metal−Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells

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Fabrication of dopamine conjugated with protein @metal organic framework for targeted drug delivery: A biocompatible pH-Responsive nanocarrier for gemcitabine release on MCF‑7 human breast cancer cells

Cited by 22 publications

References 42 publications

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Corn‐like mSiO2@ZIF‐8 Composite Load with Curcumin for Target Cancer Drug‐Delivery System

Gallium Metal−Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells

Contact Info

Product

Resources

About

Corn‐like mSiO₂@ZIF‐8 Composite Load with Curcumin for Target Cancer Drug‐Delivery System