Fabrication of double layer optical tissue phantom by spin coating method: mimicking epidermal and dermal layer

Park, Jihoon; Bae, Yunjin; Bae, Youngwoo; Kang, Hee-Taik; Lee, Kyoung-Joung; Jung, Byungjo

doi:10.1117/12.2003603

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…Artificial skin phantoms have conventionally been used as an essential tool to indirectly evaluate human tissue for laser therapeutics and diagnostics. A number of studies have demonstrated various methods of fabricating the skin phantoms such as mold casting and spin‐coating . However, these conventional methods were often associated with cumbersome and time‐consuming procedures, which consisted of multiple steps including thermal curing, separate layer preparation, and optimization of control parameters (spinning speed, viscosity, and deposition speed) .…”

Section: Discussionmentioning

confidence: 99%

“…Typically, the skin phantoms are used to validate physical models, to standardize imaging modalities, and to quantitatively simulate the imaged data . Conventional methods to fabricate the heterogeneous phantoms include mold casting and spin‐coating . In the case of the mold casting, the base material was poured into a pre‐manufactured mold and cured for 4–24 hour depending on the desired phantom thickness and material properties .…”

Section: Introductionmentioning

confidence: 99%

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3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

et al. 2016

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“…The difficulty in creating realistic bladder phantoms stems largely from the limitations of currently used materials (e.g., PDMS [17][18][19], PVA-C [20][21][22], latex [13]) and fabrication techniques (e.g., lathe-spinning [14], painting [13], and spin-coating [17,23]) for phantom creation. Importantly, with the emergence and clear clinical utility of multi-modality imaging technologies (e.g., WLC+OCT and WLC+BLC) it is also crucial for such phantoms to exhibit properties visible with multiple modalities.…”

Section: Introductionmentioning

confidence: 99%

Multimodal 3D cancer-mimicking optical phantom

Smith¹,

Lurie²,

Zlatev³

et al. 2016

Biomed. Opt. Express

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Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a real organ under multiple imaging modalities. We demonstrate the utility of the material and technique by fabricating the first 3D, hollow bladder phantom with realistic normal and multi-stage pathology features suitable for endoscopic detection using the gold standard imaging technique, white light cystoscopy (WLC), as well as the complementary imaging modalities of optical coherence tomography and blue light cystoscopy, which are aimed at improving the sensitivity and specificity of WLC to bladder cancer detection. The flexibility of the material and technique used for phantom construction allowed for the representation of a wide range of diseased tissue states, ranging from inflammation (benign) to high-grade cancerous lesions. Such phantoms can serve as important tools for trainee education and evaluation of new endoscopic instrumentation.

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“…We developed a phantom preparation procedure combining the advantages of silicone [8] with the precision of spin coating [9] in order to obtain multilayered objects mimicking optical properties of skin tissue [10]. We chose to use polydimethylsiloxane (PDMS) as the base material for our multilayered phantoms.…”

Section: Phantoms Preparationmentioning

confidence: 99%

Accessing deep optical properties of skin using diffuse reflectance spectroscopy

et al. 2015

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Diffuse reflectance spectroscopy characterizes composition and structure of tissues by determining their scattering and absorption properties. We have developed in our laboratory a low-cost spatially resolved diffuse reflectance spectroscopy instrument. We present in this study some results showing how to adapt this technology on multi-layered tissues. First of all, a method enabling determination of scattering and absorption properties of multi-layered phantoms is described; the adaptation of the initial methodology to focus on deep layers is especially detailed. Then some preliminary results obtained on a panel of volunteer's redness faces are presented.

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Fabrication of double layer optical tissue phantom by spin coating method: mimicking epidermal and dermal layer

Cited by 9 publications

References 3 publications

3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

Multimodal 3D cancer-mimicking optical phantom

Accessing deep optical properties of skin using diffuse reflectance spectroscopy

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