Fabrication of doxorubicin-loaded monodisperse spherical micro-mesoporous silicon particles for enhanced inhibition of cancer cell proliferation

Kurdyukov, D. A.; Eurov, D. A.; Shmakov, Stanislav V.; Kirilenko, D. A.; Kukushkina, Yu. A.; Смирнов, А. Н.; Yagovkina, M. A.; Клименко, В. В.; Koniakhin, Sergei V.; Голубев, В. Г.

doi:10.1016/j.micromeso.2019.02.029

Cited by 8 publications

(6 citation statements)

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“…Manufacturing, characterization, investigation and application of diverse small particles and, particularly, of crystalline dielectric and semiconducting nanoparticles are among the most important and intensively developing areas of contemporary scientific research and technology. The role of nanoparticle studies in domains of optics, quantum computing, chemistry, and material science permanently grows [1][2][3][4][5][6][7][8][9]; various applications penetrate biology and medicine, the nanoparticles being used as dyes, carriers, and imaging systems [10][11][12][13][14][15]. This imposes the strict necessity for tools and methods of their physical and chemical characterization [16,17], the particle size is important parameter to know.…”

Section: Introductionmentioning

confidence: 99%

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

2020

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Disorder-induced broadening of optical vibrational eigenmodes in nanoparticles of nonpolar crystals is studied numerically. The methods previously used to treat phonons in defectless particles are adjusted for numerical evaluation of the disordered problem. Imperfections in the form of Gaussian and binary disorders as well as surface irregularities are investigated thoroughly in a wide range of impurity concentrations and disorder strengths. For dilute and weak point-like impurities the regimes of separated and overlapped phonon levels are obtained and the behavior of the linewidth predicted theoretically is confirmed, the crossover scale falls into the actual range of several nanometers. These notions survive for strong dilute impurities, as well. Regimes and crossovers predicted by theory are checked and identified, and minor discrepancies are discussed. To mention a few of them: slower than in theory increasing of the linewidth with the phonon quantum number for weak disorder and only qualitative agreement between theory and numerics for resonant broadening in strong dilute disorder. The novel phenomena discovered numerically are: "mesoscopic smearing" of distribution function in the ensemble of identical disordered particles, inflection of the linewidth dependence on the impurity concentration for light "dense" binary impurities, and position dependent capability of strong impurity to catch the phonon. It is shown that surface irregularities contribute to the phonon linewidth less than the volume disorder, and their rate reveal faster decay with increasing of the particle size. It is argued that the results of present research are applicable also for quantum dots and short quantum wires.

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Section: Introductionmentioning

confidence: 99%

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

2020

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“…The pore size distribution of MSNs and MSTNs was analyzed from an adsorption branch using the NLDFT method, which is the standard slit‐pore model for N 2 adsorption, with a specific surface area and pore size analyzer (BELSORP MAX, MicrotracBEL Corp., Japan) at 77 K on silica. [ 37–39 ] The elemental contents of the NPs were measured using ICP‐MS (Agilent 7500, Agilent Technologies, USA). The surface modification of the NPs with PEG was analyzed using an FTIR spectrometer (IFS‐66/S, TENSOR 27, Bruker, USA).…”

Section: Methodsmentioning

confidence: 99%

Cavitation‐Inducible Mesoporous Silica–Titania Nanoparticles for Cancer Sonotheranostics

Lee

Kim

You

et al. 2020

Adv Healthcare Materials

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Sonodynamic therapy has received increasing attention for cancer treatments as an alternative to photodynamic therapy. However, its clinical applications have been limited by the lack of a sonosensitizer that is capable of producing sufficient amounts of reactive oxygen species (ROS) in response to ultrasound (US) exposure. Herein, PEGylated mesoporous silica-titania nanoparticles (P-MSTNs) are prepared and used as US-responsive nanocarriers for cancer sonotheranostics. Perfluorohexane (PFH), which is chosen as the gas precursor, is physically encapsulated into P-MSTNs using the oil-in-water emulsion method.

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“…Cells were incubated with 15 μg/mL of particles (unless otherwise indicated in the text), resuspended, and functionalized by mild sonication in standard tissue culture medium containing serum. The concentration of particles that was administered to the cells was based on our previous experience and on published literature that describes the biocompatibility of this nanomaterial [ 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Engineering Sub-Cellular Targeting Strategies to Enhance Safe Cytosolic Silica Particle Dissolution in Cells

et al. 2020

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Mesoporous silica particles (MSP) are major candidates for drug delivery systems due to their versatile, safe, and controllable nature. Understanding their intracellular route and biodegradation process is a challenge, especially when considering their use in neuronal repair. Here, we characterize the spatiotemporal intracellular destination and degradation pathways of MSP upon endocytosis by HeLa cells and NSC-34 motor neurons using confocal and electron microscopy imaging together with inductively-coupled plasma optical emission spectroscopy analysis. We demonstrate how MSP are captured by receptor-mediated endocytosis and are temporarily stored in endo-lysosomes before being finally exocytosed. We also illustrate how particles are often re-endocytosed after undergoing surface erosion extracellularly. On the other hand, silica particles engineered to target the cytosol with a carbon nanotube coating, are safely dissolved intracellularly in a time scale of hours. These studies provide fundamental clues for programming the sub-cellular fate of MSP and reveal critical aspects to improve delivery strategies and to favor MSP safe elimination. We also demonstrate how the cytosol is significantly more corrosive than lysosomes for MSP and show how their biodegradation is fully biocompatible, thus, validating their use as nanocarriers for nervous system cells, including motor neurons.

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Fabrication of doxorubicin-loaded monodisperse spherical micro-mesoporous silicon particles for enhanced inhibition of cancer cell proliferation

Cited by 8 publications

References 48 publications

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

Lifetimes of confined optical phonons and the shape of a Raman peak in disordered nanoparticles. II. Numerical treatment

Cavitation‐Inducible Mesoporous Silica–Titania Nanoparticles for Cancer Sonotheranostics

Engineering Sub-Cellular Targeting Strategies to Enhance Safe Cytosolic Silica Particle Dissolution in Cells

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