Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system

Lee, Byung Kook; Yun, Yeon Hee; Choi, Ji Suk; Choi, Young Keun; Kim, Jae Dong; Cho, Yong Woo

doi:10.1016/j.ijpharm.2012.02.011

Cited by 135 publications

(74 citation statements)

References 32 publications

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“…Recent research in inkjet printed pharmaceuticals has focused on solutions (Alomari et al, 2015;Genina et al, 2013;Scoutaris et al, 2011;Sandler et al, 2011;Raijada et al, 2013;Lee et al, 2012;Acosta-Vélez et al 2017), nanosuspensions (Pardeike et al, 2011), and melts Zhu et al, 2013), each of which is primarily 2D. Reel to reel type flexographic (Raijada et al, 2013;Palo et al, 2015) printing, as well as inkjet printing in combination with electrospinning have also been utilized.…”

Section: Introductionmentioning

confidence: 99%

“…Low melting temperature PEG/naproxen mixtures Zhu et al, 2013;Hsu et al, 2015) have been reported for melt based inkjet applications in which crystalline domains of the drug could be affected by PEG coatings (Hsu et al, 2015), or controlled melt cooling . Lee et al successfully produced paxlitaxel loaded poly(lactic-co-glycolic acid) microparticles with various geometries (honeycombs, grids, rings and circles) and observed that the drug release rate was dependant on the surface area of the microparticles (Lee et al, 2012). However, these printing methods are limited in that the doses produced are films, often with an edible substrate incorporated into the dosage form.…”

Section: Introductionmentioning

confidence: 99%

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3D printing of tablets using inkjet with UV photoinitiation

Clark

Alexander

Irvine

et al. 2017

International Journal of Pharmaceutics

178

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2 Additive manufacturing (AM) offers significant potential benefits in the field of drug delivery and pharmaceutical/medical device manufacture. Of AM processes, 3D inkjet printing enables precise deposition of a formulation, whilst offering the potential for significant scale up or scale out as a manufacturing platform. This work hypothesizes that suitable solvent based ink formulations can be developed that allow the production of solid dosage forms that meet the standards required for pharmaceutical tablets, whilst offering a platform for flexible and personalised manufacture. We demonstrate this using piezo-activated inkjetting to 3D print ropinirole hydrochloride. The tablets produced consist of a cross-linked poly(ethylene glycol diacrylate) (PEGDA) hydrogel matrix containing the drug, photoinitiated in a low oxygen environment using an aqueous solution of Irgacure 2959. At a Ropinirole HCl loading of 0.41mg, drug release from the tablet is shown to be Fickian. Raman and IR spectroscopy indicate a high degree of cross-linking and formation of an amorphous solid dispersion. This is the first publication of a UV inkjet 3D printed tablet. Consequently, this work opens the possibility for the translation of scalable, high precision and bespoke ink-jet based additive manufacturing to the pharmaceutical sector.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D printing of tablets using inkjet with UV photoinitiation

Clark

Alexander

Irvine

et al. 2017

International Journal of Pharmaceutics

178

View full text Add to dashboard Cite

show abstract

“…The advancements in inkjet printing were based on the potential to print designed ratios of drugs and excipients as individual microdots onto an edible substrate. Two main inkjet dispensing systems have been investigated for pharmaceutical applications: thermal (23,25) or piezoelectric inkjet printers (26)(27)(28)(29).…”

mentioning

confidence: 99%

“…Ink jet printing requires the starting materials to possess certain characteristics mainly; particle size needs to be ˂1 µm to avoid clogging the printer head, viscosity needs to be ˂ 20 cP and surface tension between 30-70 mN/m for efficient flow (27,30). Ink jet printing is thus highly suitable for manufacturing drugs with low therapeutic doses, ideally in the microgram range, since they require a smaller area on the substrate.…”

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confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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“…Inkjet bioprinting is widely explored in the field of tissue engineering due to their unique characteristics of noncontact printing, high-throughput efficiency, automation, versatility, resolution, and possibility of parallel printing. This technology has been used to print a variety of compounds in prescribed 2D patterns, including growth factors [119], proteins [5], polymers [85], nanoparticles [190] and drugs [94]. The capability of inkjet bioprinting to print mammalian cells with high accuracy, and little or even no reduction of cell viability, was also demonstrated using different cell types, such as embryonic rat motoneurons [206], human microvascular endothelial cells [34], mouse embryonic fibroblasts [194], and retinal ganglion cells [12].…”

Section: Inkjet Bioprintingmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system

Cited by 135 publications

References 32 publications

3D printing of tablets using inkjet with UV photoinitiation

3D printing of tablets using inkjet with UV photoinitiation

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

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