Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension

Kakran, Mitali; Sahoo, Nanda Gopal; Li, L.; Judeh, Zaher M. A.; Wang, Y.; Chong, Kwok Feng; Loh, Leonard

doi:10.1016/j.ijpharm.2009.09.030

Cited by 99 publications

(43 citation statements)

References 23 publications

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“…Kakran et al used 0.45 μm filter for artemisinin particles with diameters between 100 and 360 nm. (41). The main purpose of the filter was to separate large aggregates of drug particles (>200 nm) and clusters of disintegrated film from the dissolution sample with the assumptions that GF nanoparticles <200 nm dissolve relatively fast.…”

Section: Flow-through Cell Dissolution Methods (Usp 4)mentioning

confidence: 99%

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

et al. 2012

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Abstract. Recent interest in the development of drug particle-laden strip-films suggests the need for establishing standard regulatory tests for their dissolution. In this work, we consider the dissolution testing of griseofulvin (GF) particles, a poorly water-soluble compound, incorporated into a strip-film dosage form. The basket apparatus (USP I) and the flow-through cell dissolution apparatus (USP IV) were employed using 0.54% sodium dodecyl sulfate as the dissolution medium as per USP standard. Different rotational speeds and dissolution volumes were tested for the basket method while different cell patterns/ strip-film position and dissolution media flow rate were tested using the flow-through cell dissolution method. The USP I was not able to discriminate dissolution of GF particles with respect to particle size. On the other hand, in the USP IV, GF nanoparticles incorporated in strip-films exhibited enhancement in dissolution rates and dissolution extent compared with GF microparticles incorporated in strip-films. Within the range of patterns and flow rates used, the optimal discrimination behavior was obtained when the strip-film was layered between glass beads and a flow rate of 16 ml/min was used. These results demonstrate the superior discriminatory power of the USP IV and suggest that it could be employed as a testing device in the development of strip-films containing drug nanoparticles.

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Section: Flow-through Cell Dissolution Methods (Usp 4)mentioning

confidence: 99%

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

et al. 2012

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“…Firstly, a higher drug concentration can create a higher supersaturation that favors to form a faster nucleation rate, resulting in small particle size (Chen et al, 2004;Matteucci et al, 2006); secondly, as the concentration was gradually increased to 35 mg/mL, the increased viscosity of drug solution hindered the diffusion between solution and antisolvent, thereby promoting aggregation of particles (Kakran et al, 2010;Zhang et al, 2006); finally, the much higher drug concentration, 35 mg/mL, also brought about a large number of nuclei in the interface of antisolvent and solvent. So the diffusion from solvent to antisolvent was decreased and subsequent agglomeration occurred (Kakran et al, 2010;Matteucci et al, 2006). As a result, 30 mg/mL was chosen to be one of the optimum conditions for preparation of m-EA.…”

Section: Concentration Of Ea Solutionmentioning

confidence: 99%

Preparation and characterization of micronized ellagic acid using antisolvent precipitation for oral delivery

Zhao

et al. 2015

International Journal of Pharmaceutics

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“…Of late, nanoscience-based approaches such as nanocrystals [7À9] and nanosuspensions [10,11] are rapidly gaining popularity in pharmaceutical sciences.…”

Section: Introductionmentioning

confidence: 99%

Enhanced dissolution characteristics of piroxicam–Soluplus® nanosuspensions

Patnaik

Chunduri

Akilesh

et al. 2016

Journal of Experimental Nanoscience

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In the present study, we have prepared nanosuspensions of piroxicam using Soluplus® as the matrix using aqueous-based conventional ball milling. The comparative physico-chemical characteristics were assessed using PXRD (powder X-ray diffraction), DSC (differential scanning calorimetry), FESEM (field emission scanning electron microscopy) and FTIR (Fourier transform infrared spectroscopy) analysis, indicating the nanoformulations displayed lower crystallinity with no chemical interactions between the drug and polymer molecules. The cytotoxicity of the formulations was established from MTT assay performed on Caco-2 cell lines. The release rate of piroxicam from various ratios of drug/polymer nanoparticles was investigated using a USP paddle apparatus. The nanoformulations exhibited higher release of the drug in comparison with the pure drug. The enhanced dissolution characteristics of the drug in the nanoformulations could possibly increase the anti-inflammatory effects of the drug owing to superior bioavailability characteristics.

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Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension

Cited by 99 publications

References 23 publications

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

Preparation and characterization of micronized ellagic acid using antisolvent precipitation for oral delivery

Enhanced dissolution characteristics of piroxicam–Soluplus® nanosuspensions

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