Fabrication of electroactive polypyrrole-tungsten disulfide nanocomposite for enhanced in vivo drug release in mice skin

Encapsulation and Storage of Therapeutic Fibrin-Homing Peptides using Conducting Polymer Nanoparticles for Programmed Release by Electrical Stimulation

“…Moreover, the potential of electro-responsive CP NPs has been recently extended to neutral drugs, such as curcumin, allowing their electrically pulsed, linearly scalable, and on-demand release. , Notably, although CREKA has been incorporated to CP films to promote its ability to bind fibrin–fibronectin complexes, , this pentapeptide has never been loaded in CP NPs to modulate and program its controlled release with the applied stimulus. Although the utilization of CPs as drug delivery systems for humans is still in its early stages, in vivo assays using different types of electrochemical techniques for electrical stimulation have been successfully conducted. − …”

Unleashing the potential of tungsten disulfide: Current trends in biosensing and nanomedicine applications

“…Another notable survey is that of Hsiao et al [ 223 ] , in which an electrically responsive model for 5-fluorouracil (5-FU) as anticancer drug loading was developed. To do so, the exfoliated WS 2 was modified with thiol-terminated ligands, such as thioglycolic acid (TGA), 2-ethanethiol (2 E T), and dimercaptosuccinic acid (MSA), then coated with the electrically conductive polypyrrole (PPy).…”

Electroconductive multi-functional polypyrrole composites for biomedical applications

“…Other stimulus-responsive characteristics may be introduced by using transition metals such as exfoliated tungsten disulfide (WS 2 ). The latter may be functionalized with thiol-terminated ligands using thiol chemistry [118] . When the exfoliated WS 2 was coated non-covalently with polypyrrole, the system became responsive to electrical stimulus, with a release rate of up to 90% for a loaded drug.…”