Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Lee, Il Woo; Li, Jinglei; Chen, Xiguang; Park, Hyun Jin

doi:10.1002/app.44859

Cited by 18 publications

(4 citation statements)

References 70 publications

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“…The sample (10 mg) was loaded into an aluminum pan and covered with a lid. Then the sample was heated from 20 to 500 °C at a rate of 10 °C/min under nitrogen purge [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Optimization of EPS Production and Characterization by a Halophilic Bacterium, Kocuria rosea ZJUQH from Chaka Salt Lake with Response Surface Methodology

Jiao²,

et al. 2017

Molecules

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With the rising awareness of microbial exopolysaccharides (EPSs) application in various fields, halophilic microorganisms which produce EPSs have received broad attention. A newly identified Kocuria rosea ZJUQH CCTCC M2016754 was determined to be a moderate halobacterium on account of its successful adaption to the environment containing 10% NaCl. The optimal combination of fermentation medium compositions on EPS production was studied. In this work, a fractional factorial design was adopted to investigate the significant factors that affected EPS production. The factors of KCl and MgSO4 were found to have a profound impact on EPS production. We utilized central composite design and response surface methodology to derive a statistical model for optimizing the submerged culture medium composition. Judging from these experimental results, the optimum culture medium for producing EPSs was composed of 0.50% casein hydrolysate, 1.00% sodium citrate, 0.30% yeast extract, 0.50% KCl, 0.50% peptone, and 5.80% MgSO4 (initial pH 7.0). The maximal EPS was 48.01 g/L, which is close to the predicted value (50.39 g/L). In the validation experiment, the highest concentration of 70.64 g/L EPSs was obtained after 120 h under the optimized culture medium in a 5-L bioreactor. EPS from this bacterium was also characterized by differential scanning calorimetry (DSC) and Fourier transform infrared analysis (FT-IR). The findings in this study imply that Kocuria rosea ZJUQH has great potential to be exploited as a source of EPSs utilized in food, the pharmaceutical and agriculture industry, and in the biotreatment of hypersaline environments.

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“…The sample (10 mg) was loaded into an aluminum pan and covered with a lid. Then the sample was heated from 20 to 500 °C at a rate of 10 °C/min under nitrogen purge [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Optimization of EPS Production and Characterization by a Halophilic Bacterium, Kocuria rosea ZJUQH from Chaka Salt Lake with Response Surface Methodology

Jiao²,

et al. 2017

Molecules

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“…In the particular case reviewed, it was used for an expected hydrogen bond in the -O-group with the active compound [19]. Pluronic is a copolymer composed of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO): this structure gives pluronic a hydrophobic (PPO) and a hydrophilic section (PEO), which is why it is used in hydrophobic or water-insoluble drug delivery [20]. Gelatin can be classified as a semisynthetic polymer due to its origin in the hydrolysis of collagen (natural polymer).…”

Section: Polymeric Matrices Of Electrospun Nanofibersmentioning

confidence: 99%

“…Pullulan is a natural, nontoxic polysaccharide produced by a fungus with flexible characteristics: it is a biopolymer (directly synthesized by living beings such as proteins or polysaccharides) and has commonly been tested for drug delivery, among other applications [20,27].…”

Section: Polymeric Matrices Of Electrospun Nanofibersmentioning

confidence: 99%

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Applications of Electrospun Nanofibers with Antioxidant Properties: A Review

et al. 2020

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Antioxidants can be encapsulated to enhance their solubility or bioavailability or to protect them from external factors. Electrospinning has proven to be an excellent option for applications in nanotechnology, as electrospun nanofibers can provide the necessary environment for antioxidant encapsulation. Forty-nine papers related to antioxidants loaded onto electrospun nanofibers were categorized and reviewed to identify applications and new trends. Medical and food fields were commonly proposed for the newly obtained composites. Among the polymers used as a matrix for the electrospinning process, synthetic poly (lactic acid) and polycaprolactone were the most widely used. In addition, natural compounds and extracts were identified as antioxidants that help to inhibit free radical and oxidative damage in tissues and foods. The most recurrent active compounds used were tannic acid (polyphenol), quercetin (flavonoid), curcumin (polyphenol), and vitamin B6 (pyridoxine). The incorporation of active compounds in nanofibers often improves their bioavailability, giving them increased stability, changing the mechanical properties of polymers, enhancing nanofiber biocompatibility, and offering novel properties for the required field. Although most of the polymers used were synthetic, natural polymers such as silk fibroin, chitosan, cellulose, pullulan, polyhydroxybutyrate, and zein have proven to be proper matrices for this purpose.

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Drug Delivery Systems Based on Pullulan Polysaccharides and Their Derivatives

Grigoras

2019

Environmental Chemistry for a Sustainable World

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Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Cited by 18 publications

References 70 publications

Optimization of EPS Production and Characterization by a Halophilic Bacterium, Kocuria rosea ZJUQH from Chaka Salt Lake with Response Surface Methodology

Optimization of EPS Production and Characterization by a Halophilic Bacterium, Kocuria rosea ZJUQH from Chaka Salt Lake with Response Surface Methodology

Applications of Electrospun Nanofibers with Antioxidant Properties: A Review

Drug Delivery Systems Based on Pullulan Polysaccharides and Their Derivatives

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