Fabrication of Free-Standing Hybrid Nanosheets Organized with Polymer Langmuir−Blodgett Films and Gold Nanoparticles

Endô, Hiroshi; Kado, Yuko; Mitsuishi, Masaya; Miyashita, Tokujı

doi:10.1021/ma052410j

Cited by 48 publications

(40 citation statements)

References 26 publications

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“…Recent developments in nanotechnology have made it possible to fabricate quasi, two‐dimensional, freestanding polymeric ultrathin films (polymer nanosheets or simply nanosheets) with remarkable properties, such as high flexibility, minimum surface roughness, and noncovalent adhesive properties . The polysaccharide nanosheet forms a stable platform for facilitating drug loading, with nanosheets loaded with TC for treating gastrointestinal defects, such as gastric peritonitis and other surgical defects, having been reported in the literature .…”

Section: Nanoengineered Antibiotic Delivery Systemsmentioning

confidence: 99%

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Kalhapure

Suleman

Mocktar

et al. 2015

Journal of Pharmaceutical Sciences

176

105

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Section: Nanoengineered Antibiotic Delivery Systemsmentioning

confidence: 99%

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Kalhapure

Suleman

Mocktar

et al. 2015

Journal of Pharmaceutical Sciences

176

105

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“…Most recently, Miyashita and co-workers have prepared LB multilayers of poly(N-dodecylacrylamide) copolymer, and have demonstrated that these nanosheets with sub-millimeter sizes are free-standing. 9 …”

Section: Nanometer-thick Membranes From Linear Polymers and By The Lamentioning

confidence: 99%

Development of Fabrication of Giant Nanomembranes

Watanabe

Vendamme

Kunitake

2007

Bulletin of the Chemical Society of Japan

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Large nanomembranes, which are characterized by aspect ratios (size/thickness) of greater than one million, are described. The combination of nanometer thickness and macroscopic size facilitates important applications in materials separation, selective transport and electrochemical devices. In the past, only small pieces of nanomembranes have been fabricated, in spite of intensive research. We describe here the first examples of a general fabrication procedure. Spin coating of the precursor solutions on appropriate underlayer was effectively used to prepare 10-30 nm thick nanomembranes of metal oxides, interpenetrating network of cross-linked acrylate with metal oxide, and highly cross-linked organic polymers (epoxy resin, etc.). The underlayer is composed of an affinity (e.g., poly(vinyl alcohol)) layer and/ or sacrificial layer, and the role of these layers is discussed. Some of the mechanical properties of nanomembranes were measured by using a bulge test and a compression method. The nanomembranes of the organic and inorganic hybrids and the purely organic resins were surprisingly robust and defect-free.

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“…[1][2][3][4][5] Work in this area has focused on their macromolecular organization to exploit their unique properties, such as high flexibility, adhesiveness, and transparency. These attractive properties are derived from the large aspect ratio of the size of the film (over 10 6 ); they are approximately 1 cm laterally and tens of nanometers thick, giving them similar dimension to a cell membrane or the extracellular matrices in living organisms.…”

Section: Introductionmentioning

confidence: 99%

Adhesive, Flexible, and Robust Polysaccharide Nanosheets Integrated for Tissue‐Defect Repair

Fujie

Matsutani

Kinoshita

et al. 2009

Adv Funct Materials

166

171

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Recent developments in nanotechnology have led to a method for producing free‐standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro‐scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 × 104 N m−1, and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheet‐type nano‐biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.

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Fabrication of Free-Standing Hybrid Nanosheets Organized with Polymer Langmuir−Blodgett Films and Gold Nanoparticles

Cited by 48 publications

References 26 publications

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Development of Fabrication of Giant Nanomembranes

Adhesive, Flexible, and Robust Polysaccharide Nanosheets Integrated for Tissue‐Defect Repair

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