Fabrication of Glass Microfluidic Devices

Culbertson, Christopher T.; Sibbitts, Jay; Sellens, Kathleen A.; Jia, Shu

doi:10.1007/978-1-4939-8964-5_1

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…For full-body glass chips, etched glass substrates are covered by a flat glass substrate using high-temperature fusion bonding processes. 119 Recently, 3D printing received attention for the fabrication of microfluidic devices. Gal-or et al developed a molten soda-lime glass microfluidic device by additive manufacturing (3D printing) in tens of minutes.…”

Section: Materials and Fabricationmentioning

confidence: 99%

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

et al. 2022

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Section: Materials and Fabricationmentioning

confidence: 99%

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

et al. 2022

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“…Glass can be etched through wet methods with chemical solutions or dry methods using plasma to imprint microstructures onto its surface, which is especially relevant for devices that require bonding with the glass itself or a PDMS layer to enclose the reaction system. [15][16] Even prior to the introduction of microfluidics as a concept, glass capillary microchannels were used in gas chromatography. [17] Recently, Wen and coworkers applied a sensitive and self-driven glass capillary device to detect cocaine based on small changes in hydrogels.…”

Section: Inorganic Materialsmentioning

confidence: 99%

Integrated microfluidic devices for in vitro diagnostics at point of care

Liu

Wang

et al. 2022

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Given the continuous and growing demand for point of care (POC) diagnostic tests, attention has been shifted toward integration and miniaturization of laboratory protocols into “sample‐in‐answer‐out” devices. Microfluidic technologies have been considered an ideal solution to address the requirements of POC diagnostics since many laboratory functions can be miniaturized and incorporated onto a single integrated chip. In this review, we summarize the advances of integrated microfluidic devices for POC diagnostics in the last 3 years. Particularly, we summarize current materials used for microfluidic chip fabrication, discuss the innovation of versatile integrated microfluidic devices, especially the strategies for simplifying sample preparation in manual or self‐driven systems, and new detection methods of microfluidic chips. In addition, we describe new integrated microfluidic devices for POC diagnostics of protein‐targeted immunodiagnostics, nucleic acid molecular tests, and small molecule metabolites analysis. We also provide future perspectives and current challenges for clinical translation and commercialization of these microfluidic technologies.

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“…Thereby, the weaken performance of Ushaped channels are expected to be due to their lower cross section area derived from the limitations to fabricate deeper glass channels. Nevertheless, there are some situations where glass channels might be preferred over SU-8 or polymeric devices on account of their strength, durability, chemical and heat resistance and optical transparency [33][34][35]68]. In this regard, optimizing their performance in order to enhance the system throughput while maintaining complete bead collection is imperative so as to microfluidic-magnetophoretic devices could be effectively employed.…”

Section: Influence Of Microchannel Cross Section Shapementioning

confidence: 99%

Continuous-Flow Separation of Magnetic Particles from Biofluids: How Does the Microdevice Geometry Determine the Separation Performance?

Fernández

Gómez-Pastora

Basauri

et al. 2020

Sensors

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The use of functionalized magnetic particles for the detection or separation of multiple chemicals and biomolecules from biofluids continues to attract significant attention. After their incubation with the targeted substances, the beads can be magnetically recovered to perform analysis or diagnostic tests. Particle recovery with permanent magnets in continuous-flow microdevices has gathered great attention in the last decade due to the multiple advantages of microfluidics. As such, great efforts have been made to determine the magnetic and fluidic conditions for achieving complete particle capture; however, less attention has been paid to the effect of the channel geometry on the system performance, although it is key for designing systems that simultaneously provide high particle recovery and flow rates. Herein, we address the optimization of Y-Y-shaped microchannels, where magnetic beads are separated from blood and collected into a buffer stream by applying an external magnetic field. The influence of several geometrical features (namely cross section shape, thickness, length, and volume) on both bead recovery and system throughput is studied. For that purpose, we employ an experimentally validated Computational Fluid Dynamics (CFD) numerical model that considers the dominant forces acting on the beads during separation. Our results indicate that rectangular, long devices display the best performance as they deliver high particle recovery and high throughput. Thus, this methodology could be applied to the rational design of lab-on-a-chip devices for any magnetically driven purification, enrichment or isolation.

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Fabrication of Glass Microfluidic Devices

Cited by 9 publications

References 7 publications

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

Integrated microfluidic devices for in vitro diagnostics at point of care

Continuous-Flow Separation of Magnetic Particles from Biofluids: How Does the Microdevice Geometry Determine the Separation Performance?

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