Fabrication of HA/PEI-functionalized carbon dots for tumor targeting, intracellular imaging and gene delivery

Zhang, M.; Xiao-jun, Zhao; Fang, Zhengzou; Niu, Yaran; Lou, J.; Wu, Yan; Zou, Shengqiang; Sheng, Xia; Sun, Mingzhong; Du, F.

doi:10.1039/c6ra26048a

Cited by 81 publications

(52 citation statements)

References 36 publications

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“…Hyaluronic acid (HA) was used for the functionalization of nitrogen-doped carbon quantum dots (HA-CQDs) that provide robust fluorescent dots for use in confocal microscopy and flow cytometry. The results proved that HA-CQDs can be used as a new biocompatible cell-specific targeting probe for imaging of CD44 receptor-over expressed in cancer cells [110][111][112]. Besides targeting the specific cells, high selectivity on the organelle is another way to achieve the targeting function.…”

Section: Fluorescent Cds Conjugated With Targeting Unitmentioning

confidence: 84%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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Section: Fluorescent Cds Conjugated With Targeting Unitmentioning

confidence: 84%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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“…The bismuth element of HA-Bi 2 O 3 NPs was quantified by linear calibration using amounts of potassium iodine previously determined by inductively coupled plasma mass spectroscopy (ICP-MS). 36 and incubated for 24 h at 37°C and 5% CO 2 , and then the growth medium was replaced with DMEM containing different concentrations of HA-Bi 2 O 3 NPs. Each sample was prepared in triplicate.…”

Section: Instrumentation and Characterizationsmentioning

confidence: 99%

Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

Lou

Jiang

et al. 2017

IJN

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The inherent radioresistance and inaccuracy of localization of tumors weaken the clinical implementation effectiveness of radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi 2 O 3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging and radiosensitization of tumor. After functionalization with hyaluronic acid, the Bi 2 O 3 NPs possessed favorable solubility in water and excellent biocompatibility and were uptaken specifically by cancer cells overexpressing CD44 receptors. The as-prepared HA-Bi 2 O 3 NPs exhibited high X-ray attenuation efficiency and ideal radiosensitivity via synergizing X-rays to induce cell apoptosis and arrest the cell cycle in a dose-dependent manner in vitro. Remarkably, these properties offered excellent performance in active-targeting CT imaging and enhancement of radiosensitivity for inhibition of tumor growth. These findings demonstrated that HA-Bi 2 O 3 NPs as theranostic agents exhibit great promise for CT imaging-guided radiotherapy in diagnosis and treatment of tumors.

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“…The N 1s spectrum of BP-DEX/PEI nanoparticles in Fig. 1e shows two peaks at 399.2 and 401.2 eV, which can be attributed to the binding energies of N from C-N and N-H bonds [31], confirming the successful modification of BP with PEI. The two distinct peaks at 129.3 and 130.2 eV are assigned to 2p 3/2 and 2p 1/2 orbitals of zero-valence phosphorous in the P 2p spectrum, respectively (Fig.…”

Section: Characterization Of Bp-dex/pei Nanoparticlesmentioning

confidence: 65%

Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

Deng

Sun

et al. 2018

Science Bulletin

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Fabrication of HA/PEI-functionalized carbon dots for tumor targeting, intracellular imaging and gene delivery

Abstract: Carbon quantum dots (CDs) as emerging carbon nano-materials have attracted tremendous attention in biomedical fields due to unique properties.

Cited by 81 publications

References 36 publications

Recent advance of carbon dots in bio-related applications

Recent advance of carbon dots in bio-related applications

Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

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