Fabrication of injectable hydrogels from an anticancer peptide for local therapeutic delivery and synergistic photothermal–chemotherapy

Abstract

The susceptibility of anticancer peptides to proteolytic degradation is often considered as a major weakness that limits systemic therapeutic applications. However, localized delivery of anticancer peptides via injectable hydrogels is...

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

“…12). 121 The dynamic imine linkages and strong Fe( iii )–catechol coordination interactions provided a supramolecular hydrogel. This material has good self-healing properties, mechanical stability, and thermal and pH responsiveness.…”

Modulation of hydrogel networks by metal ions

“…34 However, the recent, big boost of applications, as 3D bioprinting and biofabrication, will promote these studies in the future. 17,[99][100][101][102][103][104] Fe 3+ /catechol complexes are employed as delivery systems of anti-cancer drug 105 : These complexes form chitosan hydrogels capable of incorporating hydrophobic and hydrophilic drugs such as doxorubicin hydrochloride and docetaxel. 85 While catechol hydrogels exhibit poor mechanical, limited encapsulation efficacy, slow self-healing properties, and burst drug release, 106 the chitosan-catechol hydrogel (CAT-Gel) including Fe 3+ provided a unique blend of material properties, such as injectability and self-healing, along with no cytotoxic and no hemolytic effects.…”

Designed synthesis of prussian blue@Cu-doped zinc phosphate nanocomposites for chemo/chemodynamic/photothermal combined cancer therapy

“…1 Chemotherapy is extensively selected as a clinical treatment for various cancers via the usage of chemical drugs. 2 The therapeutic effect of mono chemotherapy is greatly affected by severe side effects due to the non-specificity of free drugs, as well as drug resistance caused by the high dose and repeated usage of anti-tumor drugs. [3][4][5] To tackle these problems, the strategy of integrating other advanced therapeutic modalities with chemotherapy has been put forward to enhance the therapeutic effect on the tumor region and reduce systemic toxicity.…”