Fabrication of Interpenetrating Networks of Poly (vinyl alcohol-g-acrylamide) and Chitosan-g-polyacrylamide Chains and Evaluation of Water Sorption, Blood Compatibility and Cytotoxicity Behaviors

Prabhakar, Suman; Bajpai, Jaya; Bajpai, A. K.

doi:10.1080/03602559.2012.709297

Cited by 19 publications

(7 citation statements)

References 34 publications

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“…Inspired by the excellent biological compatibility, strong hydrogen-bond interaction to environmental molecules, and low toxicity of polyacrylamide substrates, − in this work, we aim to develop a universal and efficacious approach to decrease the aggregation effect of organic photoelectric materials and to improve biological compatibility and cell permeability as well. The basic strategy was to controllably hang organic fluorescein fluorophores on the bioactive polyacrylamide main chain with a 1:2 stoichiometric ratio via chemical covalent bonds (PAFH), which would effectively improve the optical stability of fluorescein fluorophores, lower their toxicity, and increase their cell permeability and biological compatibility as well.…”

Section: Introductionmentioning

confidence: 99%

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability

et al. 2020

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A convenient and efficient method to eliminate the aggregation effect of organic photoelectric sensing materials and to improve biological compatibility and cell permeability as well was developed by hanging organic fluorophores on a polymer chain, for example, fluorescein fluorophores had been controllably hung on polyacrylamide main chains with a 1:2 stoichiometric ratio by a simple copolymerization strategy. The results showed that introduction of water-soluble bioactive polyacrylamide main chains into fluorescein fluorophores via covalent bonds could effectively improve their optical stability by deteriorating π–π stack and charge-transfer interactions among different fluorophores. More importantly, the resultant materials possessed low toxicity and excellent cell permeability ten times larger than their precursor fluorescein fluorophore, which made it express an especially turn-on fluorescent response to ultratrace Hg2+ both in aqueous and living cells by forming stable 5-member-ring complexes with Hg2+ with a correlation coefficient of 0.997 and a low detection limit of 4.0 × 10–10 mol·L–1. This work provides promising insight into constructing some practical sensing materials for environmentally-friendly biological analyses.

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Section: Introductionmentioning

confidence: 99%

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability

et al. 2020

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“…17 The presence of LAPONITE® seems not to decrease the blood compatibility with its negatively charged surface. 48 Note that increasing DS can improve the BCI, but the DS35 hydrogel has the highest BCI. This result may be due to the reduction of the free amino groups of gelatin and the decrease of water uptake capacity.…”

Section: In Vitro Blood Compatibilitymentioning

confidence: 98%

“…Fig. 12 shows the amounts of BSA adsorbed by MA-gelatin NC gels, all of which are at a very low level (less than 0.4 mg g À1 ), 13,48 indicating good blood compatibility of the gels. As expected, the introduction of gelatin improves the wettability and hydrophilicity of the NC gel surfaces, which in turn increase the antithrombogenicity.…”

Section: In Vitro Blood Compatibilitymentioning

confidence: 99%

Novel hemocompatible nanocomposite hydrogels crosslinked with methacrylated gelatin

Lin

2016

RSC Adv.

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Methacrylated gelatin (MA-gelatin) is a gelatin derivative synthesized by the reaction with methacrylic anhydride; the degree of substitution (DS) of primary amines by methacrylamide groups in the gelatin is closely related to the dosage of methacrylic anhydride. In this work, MA-gelatin has been developed as a macromolecular crosslinker to prepare novel nanocomposite hydrogels (NC gels) based on polyacrylamide (PAAm) and LAPONITE® nanoclay. Compared with unmodified gelatin, MA-gelatin improves the stability of the LAPONITE® suspension in the pre-gel system. FTIR results confirm the success of gelatin modification, in agreement with the 1 H NMR result, and the copolymerization of MA-gelatin and acrylamide monomers in the NC gel network. The increasing DS of MA-gelatin thus reduces the equilibrium swelling ratio (ESR) and pore sizes, and enhances the mechanical properties of the NC gels, due to the macromolecular crosslinking effect. Unlike the small molecular crosslinker N,N 0 -methylenebisacrylamide (BIS), MA-gelatin shows a stronger influence on the swelling behaviours and mechanical properties of NC gels. Moreover, the MA-gelatin crosslinked NC gels exhibit decreased bovine serum albumin (BSA) adsorption, prolonged blood-clotting time and nonhemolytic nature, indicating the improved antithrombogenicity. The results show that MA-gelatin can be a hemocompatible macromolecular crosslinker for the fabrication of biomedical materials.

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“…In the recent times, there has been growing considerable interest in biomaterials for gastrointestinal drug delivery such as starch [1,2], sodium alginate [3][4][5][6], chitosan [7,8], guar gum [9,10], and dextran [11]. These biomaterials are nontoxic, of biocompatible nature, and environmentally friendly.…”

Section: Introductionmentioning

confidence: 99%

Effect of Curing Agent on Sodium Alginate Blends Using Barium Chloride as Crosslinking Agent and Study of Swelling, Thermal, and Morphological Properties

Reddy

Pandit

2013

International Journal of Polymeric Materials and Polymeric Biom

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Sodium alginate and lignosulfonic acid blends were prepared in various ratios (100=0, 80=20, and 60=40), in order to test the suitability of these blends for controlled drug delivery in variable pH medium using barium chloride as crosslinking agent. The blends were characterized by TGA and DSC, in order to study thermal degradation properties and glass transition temperature. Thermal analyses of blends were found to be degrading in multiple steps compared to their pure polymers. Crystallization characteristics are investigated using the DSC curves. Further, miscibility of blends was investigated for morphological studies by SEM.

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Fabrication of Interpenetrating Networks of Poly (vinyl alcohol-g-acrylamide) and Chitosan-g-polyacrylamide Chains and Evaluation of Water Sorption, Blood Compatibility and Cytotoxicity Behaviors

Cited by 19 publications

References 34 publications

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability

Novel hemocompatible nanocomposite hydrogels crosslinked with methacrylated gelatin

Effect of Curing Agent on Sodium Alginate Blends Using Barium Chloride as Crosslinking Agent and Study of Swelling, Thermal, and Morphological Properties

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Fabrication of Interpenetrating Networks of Poly (vinyl alcohol-g-acrylamide) and Chitosan-g-polyacrylamide Chains and Evaluation of Water Sorption, Blood Compatibility and Cytotoxicity Behaviors

Cited by 19 publications

References 34 publications

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg2+ with Improved Biological Compatibility and Cell Permeability

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg2+ with Improved Biological Compatibility and Cell Permeability

Novel hemocompatible nanocomposite hydrogels crosslinked with methacrylated gelatin

Effect of Curing Agent on Sodium Alginate Blends Using Barium Chloride as Crosslinking Agent and Study of Swelling, Thermal, and Morphological Properties

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Product

Resources

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Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability

Efficient Polymer Pendant Approach toward High Stable Organic Fluorophore for Sensing Ultratrace Hg²⁺ with Improved Biological Compatibility and Cell Permeability