Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

Maruta, Michito; Matsuya, Shigeki; Nakamura, Seiji; Ishikawa, Kunio

doi:10.4012/dmj.2010-087

Cited by 47 publications

(47 citation statements)

References 30 publications

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“…This value is more than sufficient for clinical purposes and much higher than that of porous β-TCP blocks reported to have high porosity (Duan et al, 2013;Lopez-Heredia et al, 2012;Maruta et al, 2011;Miao, Tan, Tan, & Huang, 2007;Tan et al, 2011;Wakae et al, 2008). A more important characteristic of the porous β-TCP block for clinical applications is its mechanical strength, which we measured as 1.4 ± 0.2 MPa (DTS value); the compressive strength was estimated to be approximately 5.6 MPa.…”

Section: Discussionmentioning

confidence: 49%

Bone regeneration using β‐tricalcium phosphate (β‐TCP) block with interconnected pores made by setting reaction of β‐TCP granules

Putri

Hayashi

Ishikawa

2019

J Biomedical Materials Res

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We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively.Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute. K E Y W O R D Sartificial bone substitute, dual pore, interconnected porous structure, roughened surface, β-Tricalcium phosphate

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Section: Discussionmentioning

confidence: 49%

Bone regeneration using β‐tricalcium phosphate (β‐TCP) block with interconnected pores made by setting reaction of β‐TCP granules

Putri

Hayashi

Ishikawa

2019

J Biomedical Materials Res

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“…It is fabricated by compositional transformation, based on a dissolution-precipitation reaction using α-tricalcium phosphate (α-TCP: Ca 3 (PO 4 ) 2 ) foam as the precursor [1,2,3,4]. Unfortunately, its mechanical strength is too low for its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

et al. 2016

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Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

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“…It also should have low solubility in the solution to allow a balanced dissolution and precipitation process. To date, calcite (CaCO 3) , α-tricalcium phosphate, a mixture of gypsum and calcite were proposed as precursors [7][8][9][10] . Among the array of precursors, gypsum is unique because it has self-setting ability, which allows it to be molded and shaped to how we would like it to be at room temperature.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of carbonate apatite blocks from set gypsum based on dissolutionprecipitation reaction in phosphate-carbonate mixed solution

et al. 2014

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Carbonate apatite (CO 3 Ap), fabricated by dissolution-precipitation reaction based on an appropriate precursor, is expected to be replaced by bone according to bone remodeling cycle. One of the precursor candidates is gypsum because it shows self-setting ability, which then enables it to be shaped and molded. The aim of this study, therefore, was to fabricate CO 3 Ap blocks from set gypsum. Set gypsum was immersed in a mixed solution of 0.4 mol/L disodium hydrogen phosphate (Na 2 HPO 4 ) and 0.4 mol/L sodium hydrogen carbonate (NaHCO 3 ) at 80-200°C for 6-48 h. Powder X-ray diffraction patterns and Fourier transform infrared spectra showed that CO 3 Ap block was fabricated by dissolution-precipitation reaction in Na 2 HPO 4 -NaHCO 3 solution using set gypsum in 48 h when the temperature was 100°C or higher. Conversion rate to CO 3 Ap increased with treatment temperature. CO 3 Ap block containing a larger amount of carbonate was obtained when treated at lower temperature.

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Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

Cited by 47 publications

References 30 publications

Bone regeneration using β‐tricalcium phosphate (β‐TCP) block with interconnected pores made by setting reaction of β‐TCP granules

Bone regeneration using β‐tricalcium phosphate (β‐TCP) block with interconnected pores made by setting reaction of β‐TCP granules

Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

Fabrication of carbonate apatite blocks from set gypsum based on dissolutionprecipitation reaction in phosphate-carbonate mixed solution

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