Fabrication of magnesium/zinc-metal organic framework on titanium implants to inhibit bacterial infection and promote bone regeneration

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

“…Moreover, the osteoblast viability was significantly improved under an appropriate alkaline environment (Tan et al, 2018). In comparison, some research found that the osteogenic differentiation can be inhibited along with the reduction of extracellular pH value (Shen et al, 2019; Tao et al, 2020). In this study, we performed pH 5.0 to simulate bacteria and tumor acidic microenvironment to reveal the responsiveness of Ti‐ZnO‐PBA‐NG samples.…”

Double-edged effects and mechanisms of Zn2+ microenvironments on osteogenic activity of BMSCs: osteogenic differentiation or apoptosis

“…More interestingly, during the osteogenic differentiation process of pluripotent MSCs into osteoblasts, the expression of the ZIP1 protein and zinc uptake were found both increased. 15 Hence, bidirectional transportation of zinc may play a critical role in the osteogenic differentiation of BMSCs.…”

“…14 Associated with different zinc contents and Zn 2+ release kinetics, zinc alloys and zinc-loaded biomaterials could generate various extracellular microenvironments of Zn 2+ ions showing diverse biological effects. Moreover, previous studies demonstrated that zinc ion implantation of titanium, 5 titanium surfaces modied with Znincorporated nanotube arrays 10 and zinc-doped metal-organic framework coating 15 exhibited various osteogenic activities with different dose of zinc load and release. More interestingly, the osteogenic effects of these materials did not get synchronous promotion with the increase of their Zn 2+ contents.…”

Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

“…Bacterial infection has been a common headache in our daily life or clinics. Bacterial adhere on the surface of medical materials, resulting in infections or even failure of materials or surgery operation (Chen et al, 2016;Behzadi et al, 2017;Jensen et al, 2017;Shen et al, 2019), as for GBR technique, bacterial infection has been a major reason for failure of GBR in vivo (Slutzkey et al, 2015). And thus, it is definitely needed to develop an effectively antibacterial GBR membrane, which can regain sufficient bone, and reduce bacterial infections (Shi et al, 2019;Wang et al, 2019).…”