Fabrication of modular multifunctional delivery for antitumor drugs based on host–guest recognition

Chen, Li; Zhang, Zhe; Chen, Xiaofei; Yao, Xuemei; He, Chaoliang; Chen, Xuesi

doi:10.1016/j.actbio.2015.02.029

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…Another β‐CD‐based macrocyclic pH‐sensitive drug‐delivery system was developed by Chen et al. (Figure ) . A pH‐sensitive benzimidazole‐graft‐dextran (Dex‐BM) moiety was firstly attached on β‐CD, followed by DOX encapsulation in micelles assembled by β‐CD‐decorated chain polymers.…”

Section: Supramolecular Self‐assembled Structuresmentioning

confidence: 99%

“…As ap roof-of-concept, rhodamine Ba nd doxorubicin (DOX)w ere used as modeld rugs and loaded into the mesoporouss tructure of silica nanoparticles for stimuli-responsived rug releases tudy.T he resultss howed that the magnetic nanocrystals could generate local internal heating when the SNPs were placed in an oscillating magnetic field, which furtherc aused the pseudorotaxanes to disassemble and facilitate the opening of the nanovalves for cargo release. For instance, as ingle magnetic pulse resulted in 40 Li Zibiao obtainedh is Ph.D. in 2014 from the NationalU niversityo fS ingapore.C urrently,h e is working as ar esearch scientist at the Institute of Materials Research and Engineering, A*STAR, Singapore. His research interests are focused on biodegradable and functional polymeric materials and structural properties studies in biomedical and consumer care applications.…”

Section: Supramolecular Nanoparticles Induced By Host-guest Interactionmentioning

confidence: 99%

“…Another b-CD-based macrocyclic pH-sensitive drug-delivery system was developed by Chen et al (Figure 10). [40] Ap H-sensitive benzimidazole-graft-dextran (Dex-BM) moiety was firstly attachedo nb-CD, followed by DOX encapsulation in micelles assembled by b-CD-decorated chain polymers.T he benzimidazole groups undergo protonation upon lowering of the pH which led to swelling of micelles to release the encapsulated DOX. In vitro drug-releasee xperiments indicated that around 80 %o ft he drug was released from DOX-loaded micelles at pH 5.3, while approximately 40 %o fD OX was released at pH 7.4.…”

Section: Supramolecular Micelles Induced By Host-guest Interactionmentioning

confidence: 99%

“…Illustration of host-guestmultifunctionaldelivery systems with b-CD. Reproduced with permission from Ref [40]…”

mentioning

confidence: 99%

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Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Karim

Dou

Liu

et al. 2016

Chemistry An Asian Journal

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Recent advances in host–guest chemistry have significantly influenced the construction of supramolecular soft biomaterials. The highly selective and non‐covalent interactions provide vast possibilities of manipulating supramolecular self‐assemblies at the molecular level, allowing a rational design to control the sizes and morphologies of the resultant objects as carrier vehicles in a delivery system. In this Focus Review, the most recent developments of supramolecular self‐assemblies through host–guest inclusion, including nanoparticles, micelles, vesicles, hydrogels, and various stimuli‐responsive morphology transition materials are presented. These sophisticated materials with diverse functions, oriented towards therapeutic agent delivery, are further summarized into several active domains in the areas of drug delivery, gene delivery, co‐delivery and site‐specific targeting deliveries. Finally, the possible strategies for future design of multifunctional delivery carriers by combining host–guest chemistry with biological interface science are proposed.

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Section: Supramolecular Self‐assembled Structuresmentioning

confidence: 99%

Section: Supramolecular Nanoparticles Induced By Host-guest Interactionmentioning

confidence: 99%

Section: Supramolecular Micelles Induced By Host-guest Interactionmentioning

confidence: 99%

“…Illustration of host-guestmultifunctionaldelivery systems with b-CD. Reproduced with permission from Ref [40]…”

mentioning

confidence: 99%

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Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Karim

Dou

Liu

et al. 2016

Chemistry An Asian Journal

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“…Figure 4(a) showed the results of the cells incubated with PCD0.5 CSCM/DOX, PCD1 CSCM/DOX, and PCD2 CSCM/DOX for 2 h. It exhibited gradually increased DOX fluorescence intensity toward cell nuclei as the PCD content was increased from 0.5 to 2, indicating that PCD facilitated DOX uptake by A549 cells. Evidently, DOX fluorescence intensity was the strongest in A549 cells after incubation with free DOX within 2 h. This result suggested that the diffusion of free DOX into cell nuclei was much faster than endocytosis of DOX-loaded micelles [18] .…”

Section: Scheme 1 Preparation Of Pcd Cscm/dox For Sustained Intracellmentioning

confidence: 92%

Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery

et al. 2017

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A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin) (PCD) with the molar ratios of CHOL/β-CD at 1 : 0.5, 1 : 1, and 1 : 2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.In recent years, self-assembled polyester micelles have attracted a great deal of attention in the application for drug delivery, mainly due to its optimal biodegradability and biocompatibility [1,2] . Hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polylactide (PLA) are universally used components in block copolymers, and such copolymers have shown distinctive properties in multiple studies [3,4] . Poly(L-lactide) (PLLA) and poly(Dlactide) (PDLA) are two stereoisomeric structures of PLA. In more recent studies, PEG-PLLA and PEG-PDLA copolymers were blended into stereocomplex systems of PEG-PLLA/PDLA [5,6] . It was reported that compared with isotactic polymers, the constructed stereocomplex micelles showed enhanced kinetic stability [7] , higher drug loading efficiency [8] , and more sustained drug release [9] .Cyclodextrins (CDs) are a kind of macrocyclic oligosaccharides consisting of six to eight α-Dglucopyranoside units in a ring linked by α-1,4-glycosidic bond. CDs feature distinctive construction where all polar groups are located at the surface, forming a relatively nonpolar cavity to combine various lipophilic guest molecules [10,11] , including adamantane (ADA), cholesterol (CHOL), and aromatic compounds, etc. Therefore, CDs hold enormous potential in forming host-guest inclusion systems for drug delivery. As a member of CDs whose application has been approved by the US Food and Drug Administration (FDA), β-CD is made up of seven glucopyranoside monomers and has gained wide attention due to its inclusion formation capability, along

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