Fabrication of morphologically modified strong supramolecular nanocomposite antibacterial hydrogels based on sodium deoxycholate with inverted optical activity and sustained release

Modified Low Molecular Weight Pure and Engineered Gels: A Review of Strategies towards Their Development

“…Continuous flow reactor with excellent catalytic efficiency to generate metal nanoparticles [155] . Antibacterial hydrogels and Drug delivery vehicles [8] …”

“…[7] Although LMWHs encompass a wide range of advantages over their polymeric counterpart, their microstructure is generally composed of self-assembled weak fibrous structures with low mechanical strength which is its major drawback. [8] In order to address this issue, in recent years various structural and architectural modifications have been performed in the low molecular weight gelators in order to improve their mechanical properties, shelf-life as well as stability and thus widen their applications. [2] The present review puts forward a detailed survey of the developments reported in the field of low molecular weight gelators based on urea, amino acids, and peptides, LMW saccharides, nucleobases and bile acids in recent years (Scheme 1).…”

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen

“…26 Another potential application of these nanostructured materials is the spatial control of nanoparticulate materials. 5,27 Templating hydrophilic nanoparticles and proteins into interstitial spaces of aqueous block copolymer micelle crystal lattices to form nanocomposite materials from different block copolymer architectures has been exploited. 28 Increasing temperature leads to the formation of a hydrogel from the micellar solution.…”

“…Thermosensitive systems have aroused wide interest in industrial processes and drug delivery. Stimuli-responsive systems possess unique behaviors in which they undergo predictable changes in response to specific environmental fluctuations or introduced alterations of control parameters − The operating conditions of stability in the colloidal systems are, thus, of high importance when applied to practical uses. − One of the well-known copolymers that is able to transit reversibly between micelles and hydrogels is Pluronic (or Poloxamer), a kind of amphiphilic block copolymer of poly­(ethylene oxide) n –poly­(propylene oxide) m –poly­(ethylene oxide) n . − Owing to its nontoxic nature and amphiphilic property, Pluronic serves as an injectable thermoreversible hydrogel and is widely used in topical drug delivery for intravenous, intramuscular, and subcutaneous injections. − …”

“…However, water channels in the reversed hexagonal phase are smaller in diameter and close to each other with a large interfacial curvature . Another potential application of these nanostructured materials is the spatial control of nanoparticulate materials. , Templating hydrophilic nanoparticles and proteins into interstitial spaces of aqueous block copolymer micelle crystal lattices to form nanocomposite materials from different block copolymer architectures has been exploited …”