Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine

Abstract

A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CTAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0×10−9 to 4.0×10−8 M with a detection limit of 1.63×10−10 M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the MWCNT-CTAB/GCE electrode was applied to the determination of AAP in real samples.

Electrochemical study for the simultaneous determination of phenolic compounds and emerging pollutant using an electroanalytical sensing system based on carbon nanotubes/surfactant and multivariate approach in the optimization

“…On the other hand, in general, complicated strategies for designing/ modification of electrochemical sensor must be usually performed to avoid peaks overlapping and, thus, enabling the multi-residues analysis [18][19][20][21]. In this sense, a good design to produce a simple electrochemical sensing system for simultaneous analysis determination of organic pollutants with high sensibility, selectivity, and robustness has been based on the application of carbon nanotubes as electrodic material associated with surfactants [22][23][24][25].…”

Square wave and differential pulse voltammetric methods for the analysis of olivetol at gold electrode

“…Concentration of drug in blood or plasma, urine, saliva and other easily sampled fluids can, however, be measured. The results suggest that the disposition of OLV was comfortable to a one compartment open model [23]. The rate constant of elimination (ke) in a one compartment system is obtained from the plot of concentration of OLV versus time (Fig.6).…”

Assessment of 4‐Aminoantipyrine Degradation and Mineralization by Photoelectro‐Fenton with a Boron‐Doped Diamond Anode: Optimization, Treatment in Municipal Secondary Effluent, and Toxicity

“…[19,21] The analysis of the final solution with 30 mg L À 1 Fe 2 + after 410 min of PEF, where 97 % TOC was abated, revealed the release of 0.78 mM NH 4 + ion (82.5 % of initial N) and 0.24 mM NO 3 À ion (7.3 % of initial N). From these data, the overall mineralization Reaction (7) for the drug, considering NH 4 + as the pre-eminent nitrogenated ion, can be written as follows with an n-value of 46:…”

“…The beneficial biological activity of 4-AA has been demonstrated. For example, it allows treating viral diseases [6] as well as the formation of stable iron complexes, e. g., with hemoglobin to lower blood flow, [7] although it can produce agranulocytosis, i. e., suppression of the immune system. [8] The removal of 4-AA has been studied by different technologies including ozonation [9] and several advanced oxidation processes (AOPs) such as UV/H 2 O 2 , [1] photoelectrocatalysis with TiO 2 /ITO anode, [10] and electrochemical oxidation (EO) with boron-doped diamond (BDD).…”