Fabrication of nano-indented cavities on Au for the detection of chemically-adsorbed DTNB molecular probes through SERS effect

Chang, Chia Wei; Liao, Jiunn Der; Chang, Hsien Chang; Lin, Li‐Kai; Lin, Yin Yi; Weng, Chih-Chiang

doi:10.1016/j.jcis.2011.03.032

Cited by 29 publications

(16 citation statements)

References 45 publications

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“…In Fig. S11(a), reinforced Au nanocavities induce a combined EM and chemical effect, which mostly occurs at the edges and nanostructured cavities [8,42,43]. In Fig.…”

Section: Ag Ncs On Zno Nd For the Detection Of Malachite Greenmentioning

confidence: 99%

“…The enhancement factors (EFs) of these platforms are higher than 10 7 , providing a low detection limit. With advances in nanofabrication, more sophisticated nanostructured SERS-active substrates have been developed with various nanolithography techniques, such as electron beam lithography [7], focused ion beam (FIB) [8,9], and nanomechanical indentation [10]. These techniques can easily create reproducible NSs with high EFs, which are mainly attributed to the optimization of localized surface plasmon resonance (LSPR) or the high density of hot spots on these SERS substrates.…”

Section: Introductionmentioning

confidence: 99%

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Ag nanoclusters on ZnO nanodome array as hybrid SERS-active substrate for trace detection of malachite green

Sivashanmugan

Liao

Liu

et al. 2015

Sensors and Actuators B: Chemical

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102

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“…In Fig. S11(a), reinforced Au nanocavities induce a combined EM and chemical effect, which mostly occurs at the edges and nanostructured cavities [8,42,43]. In Fig.…”

Section: Ag Ncs On Zno Nd For the Detection Of Malachite Greenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ag nanoclusters on ZnO nanodome array as hybrid SERS-active substrate for trace detection of malachite green

Sivashanmugan

Liao

Liu

et al. 2015

Sensors and Actuators B: Chemical

Self Cite

102

View full text Add to dashboard Cite

“…However, their overwhelming emissions can sometimes interfere with the Raman signal and cause a large degree of background signal when not properly quenched. 22 Finally, the use of synthetic 12,23 As a fluorophore, TRITC also features a characteristic emission wavelength at 576 nm [ Fig. 1(a)].…”

Section: Overview Of Methodsmentioning

confidence: 99%

Development of a miRNA surface-enhanced Raman scattering assay using benchtop and handheld Raman systems

et al. 2018

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DNA-functionalized nanoparticles, when paired with surface-enhanced Raman spectroscopy (SERS), can rapidly detect microRNA. However, widespread use of this approach is hindered by drawbacks associated with large and expensive benchtop Raman microscopes. MicroRNA-17 (miRNA-17) has emerged as a potential epigenetic indicator of preeclampsia, a condition that occurs during pregnancy. Biomarker detection using an SERS point-of-care device could enable prompt diagnosis and prevention as early as the first trimester. Recently, strides have been made in developing portable Raman systems for field applications. An SERS assay for miRNA-17 was assessed and translated from traditional benchtop Raman microscopes to a handheld system. Three different photoactive molecules were compared as potential Raman reporter molecules: a chromophore, malachite green isothiocyanate (MGITC), a fluorophore, tetramethylrhodamine isothiocyanate, and a polarizable small molecule 5,5-dithio-bis-(2-nitrobenzoic acid) (DTNB). For the benchtop Raman microscope, the DTNB-labeled assay yielded the greatest sensitivity under 532-nm laser excitation, but the MGITC-labeled assay prevailed at 785 nm. Conversely, DTNB was preferable for the miniaturized 785-nm Raman system. This comparison showed significant SERS enhancement variation in response to 1-nM miRNA-17, implying that the sensitivity of the assay may be more heavily dependent on the excitation wavelength, instrumentation, and Raman reporter chosen than on the plasmonic coupling from DNA/miRNA-mediated nanoparticle assemblies.

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“…The R6G solution was used as a control. The Raman enhancement (RE) was calculated for R6G-doped GNPs with respect to R6G dye respectively according to the equation: 32 RE for R6G doped GNPs = (I R6G GNPs /N R6G GNPs )/(I R6G N/ R6G ) where I R6G GNP and N R6G GNP are Raman intensities of R6G dyedoped GNPs at Raman peak 1,360 cm −1 and number of R6G molecules on GNPs, respectively. I R6G N/ R6G is the Raman intensity of R6G and number of dye molecules.…”

mentioning

confidence: 99%

“…21 The RE was calculated as described by Chang et al using the formula given in the Materials and methods section. 32 The number of R6G dye molecules in the GNPs used to obtain Raman spectra ( Figure 5B) was 120. 4 × 10 14 .…”

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confidence: 99%

Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

Kalmodia¹,

Harjwani²,

Rajeswari³

et al. 2013

IJN

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In this paper, we report a simple, rapid, and robust method to synthesize surface-enhanced Raman-scattered gold nanoparticles (GNPs) based on green chemistry. Vitis vinifera L. extract was used to synthesize noncytotoxic Raman-active GNPs. These GNPs were characterized by ultraviolet-visible spectroscopy, dynamic light-scattering, Fourier-transform infrared (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy. The characteristic surface plasmon-resonance band at ~ 528 nm is indicative of spherical particles, and this was confirmed by TEM. The N–H and C–O stretches in FTIR spectroscopy indicated the presence of protein molecules. The predominant XRD plane at (111) and (200) indicated the crystalline nature and purity of GNPs. GNPs were stable in the buffers used for biological studies, and exhibited no cytotoxicity in noncancerous MIO-M1 (Müller glial) and MDA-MB-453 (breast cancer) cell lines. The GNPs exhibited Raman spectral peaks at 570, 788, and 1,102 cm −1 . These new GNPs have potential applications in cancer diagnosis, therapy, and ultrasensitive biomarker detection.

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Fabrication of nano-indented cavities on Au for the detection of chemically-adsorbed DTNB molecular probes through SERS effect

Cited by 29 publications

References 45 publications

Ag nanoclusters on ZnO nanodome array as hybrid SERS-active substrate for trace detection of malachite green

Ag nanoclusters on ZnO nanodome array as hybrid SERS-active substrate for trace detection of malachite green

Development of a miRNA surface-enhanced Raman scattering assay using benchtop and handheld Raman systems

Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

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