Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

Kalmodia, Sushma; Harjwani, Jaidev; Rajeswari, R.; Yang, Wenrong; Barrow, Colin J.; Ramaprabhu, Sundara; Krishnakumar, Subramanian; Elchuri, Sailaja

doi:10.2147/ijn.s49447

Cited by 24 publications

(16 citation statements)

References 57 publications

(79 reference statements)

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“…The GNPs-1 and GNPs-2 were prepared as described previously 15 16 . The GNPs- anti HDM2 peptide conjugates were prepared by mixing varying concentrations of 3-mpa (Mercaptopropionic acid) modified anti-HDM2 peptide with purified GNPs (GNPS-1 and GNPs-2, separately).…”

Section: Methodsmentioning

confidence: 99%

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

Kalmodia

Parameswaran

Yang

et al. 2015

Sci Rep

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Rapid monitoring of the response to treatment in cancer patients is essential to predict the outcome of the therapeutic regimen early in the course of the treatment. The conventional methods are laborious, time-consuming, subjective and lack the ability to study different biomolecules and their interactions, simultaneously. Since; mechanisms of cancer and its response to therapy is dependent on molecular interactions and not on single biomolecules, an assay capable of studying molecular interactions as a whole, is preferred. Fourier Transform Infrared (FTIR) spectroscopy has become a popular technique in the field of cancer therapy with an ability to elucidate molecular interactions. The aim of this study, was to explore the utility of the FTIR technique along with multivariate analysis to understand whether the method has the resolution to identify the differences in the mechanism of therapeutic response. Towards achieving the aim, we utilized the mouse xenograft model of retinoblastoma and nanoparticle mediated targeted therapy. The results indicate that the mechanism underlying the response differed between the treated and untreated group which can be elucidated by unique spectral signatures generated by each group. The study establishes the efficiency of non-invasive, label-free and rapid FTIR method in assessing the interactions of nanoparticles with cellular macromolecules towards monitoring the response to cancer therapeutics.

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Section: Methodsmentioning

confidence: 99%

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

Kalmodia

Parameswaran

Yang

et al. 2015

Sci Rep

Self Cite

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“…This technique has been widely used for the identification of NPs of different chemical composition (Lu et al ., ; Chen et al ., ). Raman spectroscopy, as observed in Table , when used for the characterization of AuNPs, revealed two peaks at 589 and 1102 nm wavelengths, which are close to those previously reported for gold nanospheres (Kalmodia et al ., ). For AgNPs, three peaks at 437, 1594 and 1646 nm were identified, corresponding to values essentially similar to those found for silver nanoparticles (Lu et al ., ; Tu and Chung, ).…”

Section: Resultsmentioning

confidence: 97%

Bioreduction of precious and heavy metals by Candida species under oxidative stress conditions

Moreno

Demitri

Ruiz-Baca

et al. 2019

Microbial Biotechnology

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Summary The aim of the present work was to evaluate whether Candida species can reduce both precious and toxic pure metals from the respective molecular ions. From these results, the nanoparticles formed were studied using scanning electron microscopy with energy‐dispersive spectroscopy, Raman spectroscopy, X‐ray fluorescence spectroscopy and synchrotron radiation. Our results showed that the metal ions were reduced to their corresponding metallic nanoconglomerate or nanoparticles by Candida species. This is the first report on how yeasts of this genus are capable of achieving homeostasis (resilience) in the presence of metal ions of both precious and toxic metals by reducing them to a metallic state.

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“…Advantages of AuNPs when used in SERS includes SPR, size dependent specifications, easy surface modifications, lower toxicity associated with living cells, size and shape diversity. AuNPs can easily be functionalized with antibodies and other tumor targeting biomolecules through well-established conjugation procedures [49,50]. In recent years, several groups [51, 52] have demonstrated the potential of using AuNPs based on Raman tags for SERS.…”

Section: Nanoparticles and Raman Techniquesmentioning

confidence: 99%

Application of nanoparticles in cancer detection by Raman scattering based techniques

Ravanshad

Zadeh

Amani

et al. 2017

Nano Reviews & Experiments

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In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.

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Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

Cited by 24 publications

References 57 publications

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

Bioreduction of precious and heavy metals by Candida species under oxidative stress conditions

Application of nanoparticles in cancer detection by Raman scattering based techniques

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