Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering

Yang, Fang; Ramu, M.; Ramakrishna, Seeram; Wang, X; Ma, Yanyu; Wang, S

doi:10.1016/j.biomaterials.2003.08.062

Cited by 561 publications

(365 citation statements)

References 26 publications

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“…However, this method involves several steps, such as raw-material dissolution, gelation, solvent extraction, freezing and drying, which make this process time consuming. The advantages of this method are that it does not require any sophisticated equipment and that the resulting pore sizes and morphology can be controlled by varying the processing parameters [31,32]. The most widely used material for phase-separation foams is biodegradable PLLA, which is sometimes combined with collagen.…”

Section: Phase Separationmentioning

confidence: 99%

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Nanotechnology in regenerative medicine: the materials side

Engel

Michiardi

Navarro

et al. 2008

Trends in Biotechnology

299

205

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Section: Phase Separationmentioning

confidence: 99%

“…The most widely used material for phase-separation foams is biodegradable PLLA, which is sometimes combined with collagen. Yang et al investigated the potential of PLLA nanofibrous scaffolds prepared by phase separation for nerve TE applications [31]. The resulting scaffold supported cell differentiation and neurite outgrowth.…”

Section: Phase Separationmentioning

confidence: 99%

Nanotechnology in regenerative medicine: the materials side

Engel

Michiardi

Navarro

et al. 2008

Trends in Biotechnology

299

205

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“…[147] GO/PLLA and RGO/PLLA nanocomposites were compression molded into plates. [148,149] RGO was prepared either by adding 1.6 g of glucose in 100 ml of DMF with 100 mg of GO or by adding polyvinyl pyrrolidone (PVP) and GO at a ratio of 5:1.…”

Section: Pllamentioning

confidence: 99%

“…[150] PLLA Nanofibers GO/PCL/PLLA nanofibers were also prepared. [25,147] Although PCL and PLLA are immiscible, with the incorporation of GO, their miscibility could be improved. In the solution form, PLLA and PCL had phase separation.…”

Section: Pllamentioning

confidence: 99%

Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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“…For example, PLA was successfully used to produce nanomaterial scaffolds for tissue regeneration after spinalcord injury (Yang et al 2004). In this study, scaffolds of nanoscale PLA fibers with diameters of 50∼350 nm were fabricated using liquid-liquid separation in tetrahydrofuran system.…”

Section: Nanomaterials Scaffolds For Neuroregenerationmentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

213

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering

Cited by 561 publications

References 26 publications

Nanotechnology in regenerative medicine: the materials side

Nanotechnology in regenerative medicine: the materials side

Graphene Oxide/Polymer‐Based Biomaterials

Novel Nanomaterials for Clinical Neuroscience

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