Fabrication of nanocellulose loaded poly(AA‐co‐HEMA) hydrogels for ceftriaxone controlled delivery and crystal violet adsorption

Abstract

Superabsorbent polymer nanocomposites (SAPCs) are very promising and versatile materials for biomedical applications. In this research work, we focused on a novel nanocellulose-based SAPC, poly(acrylic acid-co-2-hyderoxy ethyl methacrylate)-grafted cellulose nanocrystal (CNC) composite, P(AA-co-HEMA)-g-CNC as a potential drug delivery vehicle and a dye adsorbent. Ceftriaxone and crystal violet were selected as a model drug and dye, respectively. P(AA-co-HEMA)-g-CNC was synthesized by graft copolymerization reaction and the product was characterized by FTIR spectroscopy. A proposed mechanism for SAPC formation was suggested and the morphology of the sample was studied by SEM spectroscopy. The swelling of SAPCs was examined in buffer solutions with pH ranged 4-12. The product exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pHs 2 and 8. Drug loading efficiency and drug release profiles of the P(AA-co-HEMA)-g-CNC as well as the dye adsorption behavior were studied in detail. Maximum drug encapsulation efficiency and dye adsorption capacity were found to be 89% and 231 mg g 21 , respectively. Conclusively, the obtained results indicated that the synthesized SAPCs could be successfully used as promising drug delivery systems and dye adsorbent materials in wastewater treatment. POLYM. COMPOS., 00:000-000,

Research Advances in Superabsorbent Polymers

“…Because hydrogels are sensitive to environmental conditions, the controlled release of drugs can be achieved by loading them onto superabsorbent polymer hydrogels [ 31 , 167 , 168 , 169 ]. Hosseinzadeh et al [ 170 ] prepared hydrogels based on AA and methacrylic acid 2-hydroxyethyl ester copolymers grafted with cellulose for controlled release of the drug ceftriaxone. The mechanism of hydrogel formation is illustrated in Figure 12 A. Evidently, pH had a strong influence on the swelling behavior of the hydrogel, reaching a maximum swelling ratio of 92 g/g at a pH of 8.…”

Nanocellulose-Based Materials for Water Treatment: Adsorption, Photocatalytic Degradation, Disinfection, Antifouling, and Nanofiltration

“…Similarly, several researches revealed that the nanocellulose can serve as a potential adsorbent for the removal of pesticides, such as chlorpyrifos [143], tetraconazole [144], diuron [145], organophosphorus [146], difenoconazole, and nitenpyram [147]. Nanocelluloses are also employed for the adsorption and elimination of hazardous drugs from industrial wastewater, such as ciprofloxacin, diclofenac [124], metronidazole [148], and ceftriaxone [149]. Nanocelluloses on their own and after anionic functionalization, can be used for cationic organic pollutants adsorption from wastewater.…”

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

“…51 The findings revealed that the drug‐loaded BSA NPs could effectively sustain drug release over 12 hours and required lower MIC values against S. aureus and E. coli compared with the conventional drug formulation. Hosseinzadeh et al 79 investigated a novel nanocellulose‐based superabsorbent polymer nanocomposites (SAPCs) using poly (acrylic acid‐co‐2‐hyderoxy ethyl methacrylate)‐grafted cellulose nanocrystal composites using ceftriaxone and crystal violet as model drugs. In vitro results showed maximum drug encapsulation efficiency suggesting the potential of the polymeric hydrogels for effective therapeutic application.…”