Fabrication of nanoemulsion-based in situ gel using moxifloxacin hydrochloride as model drug for the treatment of conjunctivitis

Prajapati, Bhupendra G.; Patel, Asha; Paliwal, Himanshu

doi:10.1016/j.fhfh.2021.100045

Cited by 15 publications

(3 citation statements)

References 29 publications

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“…Cumulative corrections obtained the total amount of drug permeated through rat skins at each time interval and plotted against the time function. 28,29 17. Future Perspective Nanoemulsions have achieved attractiveness over the past decade because of their exceptional features such as high surface area, transparent appearance, and stability.…”

Section: In-vitro Studiesmentioning

confidence: 99%

A comprehensive review on applications, preparation & characterization of nanoemulsion

Prajapati¹,

Parihar

Macwan³

et al. 2023

IJCAAP

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With time, dosage forms have progressed, from essential tablets to advanced systems, which are now more focused on providing better ease of administration to the patients. One such advantageous novel drug delivery system is Nanoemulsion based drug delivery. The Nanoemulsion-based system is reasonably a new means of enhancing drug delivery; Nanoemulsions are sub-micron size particles roughly in the size range of 50-600 nm. The review focuses on conveying information by combining various articles and study reports to understand the work done in this field. This review paper aims to serve as a tool to understand the development of Nanoemulsion. The study comprehensively analyses the preparation methods, composition, characterization, and stability and their application in drug delivery via various routes. Lastly, the paper also describes the recent five formulations prepared for nanoemulsions and their applicability as discussed in the literature.

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Section: In-vitro Studiesmentioning

confidence: 99%

A comprehensive review on applications, preparation & characterization of nanoemulsion

Prajapati¹,

Parihar

Macwan³

et al. 2023

IJCAAP

Self Cite

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show abstract

“…With a constant surfactant-to-co-surfactant ratio, pseudo-ternary phase diagram was created. 17 Sigma plot version 10.0 was used to create a pseudoternary phase diagram of nanoemulsion to determine its zone of preparation. The surfactant (Tween 80) and Co-surfactant (Triacetin) were selected in the ratios 1:1,1:2,1:3,2:1,3:1 and nanoemulsion were prepared by decreasing the oil phase (Caprol microexpress.…”

Section: Pseduo-ternary Diagrammentioning

confidence: 99%

“…The optically transparent dispersions (i.e., low absorbance due to optical clarity) had the lowest droplet size and as the optical clarity decreases, droplet size increases. 8,17…”

Section: Particle Size Determinationmentioning

confidence: 99%

Formulation and evaluation of self-nanoemulsifying drug delivery system for improved oral delivery of exemestane hydrochloride

Prajapati

Prajapati²,

Khunt³

2023

IJCAAP

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Exemestane HCl (EXM) is a new irreversible steroidal aromatase inhibitor for adjuvant therapy of hormonally sensitive breast cancer in post-menopausal women. EXM's low water solubility hinders solid oral dosage form development. The current work aims to increase EXM solubility by formulating the self nanoemulsifying drug delivery (SNEDDs) system. The water titration approach was employed in the development of SNEDDs. Based on solubility tests, SNEDDs components Caprol Microexpress and Labrafac were selected as oil phase, Tween 80 as surfactant, and Triacetin as co-surfactant. Phase investigations were carried out with various surfactant:co-surfactant ratios (1:1, 1:2, 1:3, 2:1, 3:1). Tween 80: triacetin (1:2) and (1:3) with Caprol Microexpress and Labrafac alone had the greatest nanoemulsion area. Visual evaluation, optical clarity, particle size, medication concentration, and viscosity were used to optimise 10 formulations. F3, F7, and F8 batches had the lowest size at 7.313 ± 1.44 nm, 6.379 ± 0.45 nm, and 14.67 ± 0.37 nm, respectively, with self-emulsification times under 1 min.But optical clarity data was suggested that F7 was not showing any precipitation up to 24 H. Overall, the developed SNEDDS formulation could be a promising approach for the improved oral delivery of EXE with enhanced dissolution and bioavailability.

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Drug Delivery by Micro, Nanoemulsions in Tuberculosis

Khunt

Prajapati

Prajapti

et al. 2023

Tubercular Drug Delivery Systems

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Fabrication of nanoemulsion-based in situ gel using moxifloxacin hydrochloride as model drug for the treatment of conjunctivitis

Cited by 15 publications

References 29 publications

A comprehensive review on applications, preparation & characterization of nanoemulsion

A comprehensive review on applications, preparation & characterization of nanoemulsion

Formulation and evaluation of self-nanoemulsifying drug delivery system for improved oral delivery of exemestane hydrochloride

Drug Delivery by Micro, Nanoemulsions in Tuberculosis

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