Fabrication of Nanostructures with Bottom-up Approach and Their Utility in Diagnostics, Therapeutics, and Others

Kumar, Sanjay; Bhushan, Pulak; Bhattacharya, Shantanu

doi:10.1007/978-981-10-7751-7_8

Cited by 76 publications

(36 citation statements)

References 108 publications

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“…A vast number of strategies, including electrochemical anodization and hydrothermal, sol-gel, and electrospinning methods, have been exploited to fabricate TiO 2 nanotubes. While the fabrication of TiO 2 nanotubes through bottom-up processes may be complex, variable, and lowyield, a cylindrical structure accompanied by a pure crystalline phase can be achieved [65,66]. The self-organization of nanotubes through an alkaline treatment of TiO 2 or titanium alkoxide powder can generate an anisotropic and open-end structure [67,68].…”

Section: Nanotubesmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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HIGHLIGHTS • Multifunctional TiO 2 nanostructures hold promise for advancing a wide range of biomedical applications due to a feasible integration of distinct theranostic features. • Fabrication and post-fabrication strategies implemented to generate multifunctional TiO 2 nanostructures for a broad range of biomedical applications are briefly outlined. The opportunities and challenges of TiO 2 nanomaterials are highlighted in order to open the possibility of clinical translation. ABSTRACT Titanium dioxide (TiO 2 ) nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications. TiO 2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement, thermal conversion, specific surface area, and surface activity. This review highlights certain important aspects of fabrication strategies, which are employed to generate multifunctional TiO 2 nanostructures, while outlining post-fabrication techniques with anemphasis on their suitability for nanomedicine. The biodistribution, toxicity, biocompatibility, cellular adhesion, and endocytosis of these nanostructures, when exposed to biological microenvironments, are examined in regard to their geometry, size, and surface chemistry. The final section focuses on recent biomedical applications of TiO 2 nanostructures, specifically evaluating therapeutic delivery, photodynamic and sonodynamic therapy, bioimaging, biosensing, tissue regeneration, as well as chronic wound healing.

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Section: Nanotubesmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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“…In GPD, material deposition occurs because of either a chemical reaction or a physical reaction. 117 The chemical reaction-based GPD technologies exploit the deposition of thin sold films directly from chemical reactions between the reactive gases and/or liquid precursor with the substrate material. The chemical reaction also results in some by-products in forms of gases, other solids, and so on.…”

Section: Additive Manufacturing Fabrication Technologiesmentioning

confidence: 99%

Additive manufacturing as an emerging technology for fabrication of microelectromechanical systems (MEMS)

Kumar

Bhushan

Pandey

et al. 2019

Journal of Micromanufacturing

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The recent success of additive manufacturing processes (also called, 3D printing) in the manufacturing sector has led to a shift in the focus from simple prototyping to real production-grade technology. The enhanced capabilities of 3D printing processes to build intricate geometric shapes with high precision and resolution have led to their increased use in fabrication of microelectromechanical systems (MEMS). The 3D printing technology has offered tremendous flexibility to users for fabricating custom-built components. Over the past few decades, different types of 3D printing technologies have been developed. This article provides a comprehensive review of the recent developments and significant achievements in most widely used 3D printing technologies for MEMS fabrication, their working methodology, advantages, limitations, and potential applications. Furthermore, some of the emerging hybrid 3D printing technologies are discussed, and the current challenges associated with the 3D printing processes are addressed. Finally, future directions for process improvements in 3D printing techniques are presented.

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“…in liquid or gas environments which lead to the formation of clusters of nanoparticles (NPs) by nucleation and coalescence, or other condensation phenomena. These processes lead to the creation of varieties of compositions, shapes and sizes of NPs, with remarkable physical, chemical and electronic properties [ 19 ]. For instance, due to their size-dependent interaction with light, a multitude of theranostic modalities including optical bioimaging, biosensing, light-activated therapy, thermal therapy and magnetic properties can be exploited [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

et al. 2021

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Driven by flexibility, precision, repeatability and eco-friendliness, laser-based technologies have attracted great interest to engineer or to analyze materials in various fields including energy, environment, biology and medicine. A major advantage of laser processing relies on the ability to directly structure matter at different scales and to prepare novel materials with unique physical and chemical properties. It is also a contact-free approach that makes it possible to work in inert or reactive liquid or gaseous environment. This leads today to a unique opportunity for designing, fabricating and even analyzing novel complex bio-systems. To illustrate this potential, in this paper, we gather our recent research on four types of laser-based methods relevant for nano-/micro-scale applications. First, we present and discuss pulsed laser ablation in liquid, exploited today for synthetizing ultraclean “bare” nanoparticles attractive for medicine and tissue engineering applications. Second, we discuss robust methods for rapid surface and bulk machining (subtractive manufacturing) at different scales by laser ablation. Among them, the microsphere-assisted laser surface engineering is detailed for its appropriateness to design structured substrates with hierarchically periodic patterns at nano-/micro-scale without chemical treatments. Third, we address the laser-induced forward transfer, a technology based on direct laser printing, to transfer and assemble a multitude of materials (additive structuring), including biological moiety without alteration of functionality. Finally, the fourth method is about chemical analysis: we present the potential of laser-induced breakdown spectroscopy, providing a unique tool for contact-free and space-resolved elemental analysis of organic materials. Overall, we present and discuss the prospect and complementarity of emerging reliable laser technologies, to address challenges in materials’ preparation relevant for the development of innovative multi-scale and multi-material platforms for bio-applications.

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Fabrication of Nanostructures with Bottom-up Approach and Their Utility in Diagnostics, Therapeutics, and Others

Cited by 76 publications

References 108 publications

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Additive manufacturing as an emerging technology for fabrication of microelectromechanical systems (MEMS)

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

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