Fabrication of PDMS-Based Microfluidic Devices: Application for Synthesis of Magnetic Nanoparticles

Thu, Vũ Thị; Ngoc, An Nguyen; Le, The Tam; Trung, Hoang Van; Thu, Phùng Thị; Tien, Bui Quang; Thuat, Nguyen Tran; Лам, Тран Дай

doi:10.1007/s11664-016-4424-6

Cited by 21 publications

(13 citation statements)

References 28 publications

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“…In addition, the problems posed by fast kinetically-controlled reactions can be overcome thanks to: 1) the small reaction volumes involved, 2) the high surface to volume ratio of microchannels and 3) the high heat and mass transfer rates. Seminal work in polymer-based [14][15][16][17][18], and glass-based microreactors [19], has clearly shown the benefits of using microfluidic reactors to produce magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Usón

Arruebo

Sebastián

et al. 2018

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Usón

Arruebo

Sebastián

et al. 2018

Chemical Engineering Journal

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“…Several studies have successfully produced IONPs using a device produced by photolithography. Polymers (PDMS and SU-8) were used to fabricate microfluidic devices used to produce IONPs with core sizes of approximately 10 nm in two separate studies [ 49 , 50 ]. Additionally, a PDMS and glass chip microfluidic device was fabricated using photolithography and utilized for IONP synthesis to produce NPs with core sizes ranging from 4.83 ± 1.20 to 6.69 ± 1.15 nm [ 51 ].…”

Section: Fabrication Of Microfluidic Devices For Production Of Ionmentioning

confidence: 99%

“…A few of the synthesis conditions mentioned above must be determined prior to commencement of synthesis; for instance, the type of iron salt used (e.g., iron chlorides and iron bromides), the ratio of Fe 3+ to Fe 2+ , and the polymer composition are all parameters that are set before synthesis. Studies have shown that altering the iron salt type affects the IONP core size [ 35 , 37 , 50 ]. This affect is directly correlated to the precursor anion size (Cl − , SO 4 2− , etc.).…”

Section: Experimental Design Parameters and Their Control Over Ionmentioning

confidence: 99%

Microfluidic Synthesis of Iron Oxide Nanoparticles

et al. 2020

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Research efforts into the production and application of iron oxide nanoparticles (IONPs) in recent decades have shown IONPs to be promising for a range of biomedical applications. Many synthesis techniques have been developed to produce high-quality IONPs that are safe for in vivo environments while also being able to perform useful biological functions. Among them, coprecipitation is the most commonly used method but has several limitations such as polydisperse IONPs, long synthesis times, and batch-to-batch variations. Recent efforts at addressing these limitations have led to the development of microfluidic devices that can make IONPs of much-improved quality. Here, we review recent advances in the development of microfluidic devices for the synthesis of IONPs by coprecipitation. We discuss the main architectures used in microfluidic device design and highlight the most prominent manufacturing methods and materials used to construct these microfluidic devices. Finally, we discuss the benefits that microfluidics can offer to the coprecipitation synthesis process including the ability to better control various synthesis parameters and produce IONPs with high production rates.

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“…In a very recent study, Thu et al [219] have developed a convenient approach to combine the traditional coprecipitation method and microfluidic devices for producing iron oxide nanoparticles. They designed a microfluidic reactor and exploited soft-lithography techniques to build it out of PDMS.…”

Section: Capillary Tubes Microreactormentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Fabrication of PDMS-Based Microfluidic Devices: Application for Synthesis of Magnetic Nanoparticles

Cited by 21 publications

References 28 publications

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Microfluidic Synthesis of Iron Oxide Nanoparticles

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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Fabrication of PDMS-Based Microfluidic Devices: Application for Synthesis of Magnetic Nanoparticles

Cited by 21 publications

References 28 publications

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Microfluidic Synthesis of Iron Oxide Nanoparticles

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Contact Info

Product

Resources

About

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles

Single phase microreactor for the continuous, high-temperature synthesis of <4 nm superparamagnetic iron oxide nanoparticles