Fabrication of piezoelectric Ca-P-Si-doped PVDF scaffold by phase-separation-hydration: Material characterization, in vitro biocompatibility and osteoblast redifferentiation

Gong, Tianxing; Li, Tingyu; Meng, Lisha; Chen, Yadong; Wu, Tao; Zhou, Jingqiu; Lu, Guoxiu; Wang, Zhiguo

doi:10.1016/j.ceramint.2021.11.190

Cited by 19 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the 0.5 wt % GO addition improved the piezoelectric output (1.4 times). In another study, the Ca–P–Si-doped PVDF scaffold prepared by combining phase separation and hydration had better piezoelectric properties (3.0 pC/N) than natural bone tissue (0.7 pC/N), with mechanical strength (7 MPa) and high porosity (∼45.0%) similar to cancellous bone . Different from this method, the thermally induced phase separation method achieves polymer aggregation to form a scaffold through temperature changes, which can effectively control the structure and stability of the scaffold.…”

Section: Fabrication Methodsmentioning

confidence: 99%

Section: Applications In Tissue Repairmentioning

confidence: 99%

“…For example, Gong et al. applied phase-separation-hydration to fabricate the Ca–P–Si-doped PVDF scaffold with a mechanical strength of 7.0 MPa similar to cancellous bone, a higher piezoelectric property (3.0 pC/N) than native bone and a porosity of 45.0% . Higher porosity and piezoelectric properties promoted osteoblast cell infiltration, bone ingrowth, and osteoblast redifferentiation (Figure E).…”

Section: Applications In Tissue Repairmentioning

confidence: 99%

See 2 more Smart Citations

Scaffold-Based Poly(Vinylidene Fluoride) and Its Copolymers: Materials, Fabrication Methods, Applications, and Perspectives

Sun,

Gao,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Tissue engineering involves implanting grafts into damaged tissue sites to guide and stimulate the formation of new tissue, which is an important strategy in the field of tissue defect treatment. Scaffolds prepared in vitro meet this requirement and are able to provide a biochemical microenvironment for cell growth, adhesion, and tissue formation. Scaffolds made of piezoelectric materials can apply electrical stimulation to the tissue without an external power source, speeding up the tissue repair process. Among piezoelectric polymers, poly-(vinylidene fluoride) (PVDF) and its copolymers have the largest piezoelectric coefficients and are widely used in biomedical fields, including implanted sensors, drug delivery, and tissue repair. This paper provides a comprehensive overview of PVDF and its copolymers and fillers for manufacturing scaffolds as well as the roles in improving piezoelectric output, bioactivity, and mechanical properties. Then, common fabrication methods are outlined such as 3D printing, electrospinning, solvent casting, and phase separation. In addition, the applications and mechanisms of scaffold-based PVDF in tissue engineering are introduced, such as bone, nerve, muscle, skin, and blood vessel. Finally, challenges, perspectives, and strategies of scaffold-based PVDF and its copolymers in the future are discussed.

show abstract

Section: Fabrication Methodsmentioning

confidence: 99%

Section: Applications In Tissue Repairmentioning

confidence: 99%

Section: Applications In Tissue Repairmentioning

confidence: 99%

See 1 more Smart Citation

Scaffold-Based Poly(Vinylidene Fluoride) and Its Copolymers: Materials, Fabrication Methods, Applications, and Perspectives

Sun,

Gao,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…[15] The growth and proliferation of cells can be improved by using piezoelectric and conductive scaffolds. PVDF was used to enhance the electrical activity of scaffolds in order to repair bone [16] and nerve tissue. [17] The successful use of PVDF-based substrate as a cardiac, [18] neural, [19] endothelial, and vascular, [20] scaffolding has been the subject of various studies.…”

Section: Introductionmentioning

confidence: 99%

Study of Electrospun PVDF/GO Nanofibers as a Conductive Piezoelectric Heart Patch for Potential Support of Myocardial Regeneration

Doustvandi,

Imani,

Yousefzadeh

2023

Macro Materials & Eng

View full text Add to dashboard Cite

Heart patches are currently being utilized to repair damaged myocardium and are a promising way to address the limitations of current therapeutic strategies. Given the electromechanical nature of cardiac tissue, conductive or piezoelectric materials are of interest to researchers. An electrospinning method is used to synthesize and evaluate polyvinylidene fluoride/graphene oxide (PVDF/GO) nanocomposites. Effects of GO concentration (0, 0.1, 0.3, 0.5, 0.7, and 1 wt%) on the main physical‐mechanical characteristics of the patch are studied. Results show nanofibers containing 0.7 wt% GO with a diameter of 857 ± 168 nm, provide excellent tensile strength (0.51 ± 10.34 MPa). Fourier transform infrared and X‐ray diffraction analysis confirm the increase of the β‐polymer phase by adding 1 wt% of GO from 63% to 86%. However, the highest output voltage in the piezoelectric shock test is recorded at 9.44 V for a concentration of 0.5 wt%, which is increased by 8.2 times compared to the neat PVDF. In addition, human umbilical vein endothelial cell culture on the electrospun patches confirmed no toxicity as well as increased cell growth and proliferation (3.4 times) over 7 d. The developed material has the potential to be utilized as a heart patch due to its promising characteristics.

show abstract

“… 26 Besides, porous scaffolds with desired properties, such as proper mechanical property, good inner pore architecture, and appropriate bioactivity, are highly demanded for tissue regeneration. 27 , 28 Therefore, numerous scaffolds were developed with synthetic or natural polymers using a lot of techniques including phase separation, 29 solvent casting-particulate leaching, 30 fiber meshes, 31 gas foaming, 32 , 33 rapid prototyping, 34 and a series of three-dimensional (3D) or four-dimensional (4D) printing approaches. 35 , 36 Among these technologies, one of the attractive advantages of phase separation is that a highly interconnected porous structure can be controllably and scalably formed by simply regulating the fabrication parameters, such as polymer concentration, temperature, etc, and bioactive compounds can be directly incorporated without affecting intrinsic biological function.…”

Section: Introductionmentioning

confidence: 99%

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Guo¹,

Li²,

Wang³

et al. 2022

IJN

View full text Add to dashboard Cite

Introduction As a popular dietary supplement containing sulfur compound, methylsulfonylmethane (MSM) has been widely used as an alternative oral medicine to relieve joint pain, reduce inflammation and promote collagen protein synthesis. However, it is rarely used in developing bioactive scaffolds in bone tissue engineering. Methods Three-dimensional (3D) hydroxyapatite/poly (lactide- co -glycolide) (HA/PLGA) porous scaffolds with different doping levels of MSM were prepared using the phase separation method. MSM loading efficiency, in vitro drug release as well as the biological activity of MSM-loaded scaffolds were investigated by incubating mouse pre-osteoblasts (MC3T3-E1) in the uniform and interconnected porous scaffolds. Results Sustained release of MSM from the scaffolds was observed, and the total MSM release from 1% and 10% MSM/HA/PLGA scaffolds within 16 days was up to 64.9% and 68.2%, respectively. Cell viability, proliferation, and alkaline phosphatase (ALP) activity were significantly promoted by incorporating 0.1% of MSM in the scaffolds. In vivo bone formation ability was significantly enhanced for 1% MSM/HA/PLGA scaffolds indicated by the repair of rabbit radius defects which might be affected by a stimulated release of MSM by enzyme systems in vivo. Discussion Finding from this study revealed that the incorporation of MSM would be effective in improving the osteogenesis activity of the HA/PLGA porous scaffolds.

show abstract

Fabrication of piezoelectric Ca-P-Si-doped PVDF scaffold by phase-separation-hydration: Material characterization, in vitro biocompatibility and osteoblast redifferentiation

Cited by 19 publications

References 31 publications

Scaffold-Based Poly(Vinylidene Fluoride) and Its Copolymers: Materials, Fabrication Methods, Applications, and Perspectives

Scaffold-Based Poly(Vinylidene Fluoride) and Its Copolymers: Materials, Fabrication Methods, Applications, and Perspectives

Study of Electrospun PVDF/GO Nanofibers as a Conductive Piezoelectric Heart Patch for Potential Support of Myocardial Regeneration

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Contact Info

Product

Resources

About