Fabrication of polycaprolactone nanofibrous scaffolds by facile phase separation approach

Liu, Shuqiong; He, Zhihang; Xu, Guojie; Xiao, Xiufeng

doi:10.1016/j.msec.2014.08.012

Cited by 41 publications

(20 citation statements)

References 28 publications

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“…The second type of control samples was the nanofibrous scaffolds prepared via the thermally induced phase separation (TIPS) method, while the third type of control samples was the nanofibrous scaffolds with macropores prepared via combination of TIPS method and porogen leaching technique (TIPS&P); the detailed preparation procedures and conditions can be found in the Supporting Information. Figure shows the comparison of morphological structures between TISA and TIPS&P scaffolds.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering

Miszuk

Zhao

et al. 2015

Adv Healthcare Materials

253

193

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For the first time, electrospun polycaprolactone (PCL) 3D nanofibrous scaffold has been developed by an innovative and convenient approach (i.e., thermally induced nanofiber self-agglomeration followed by freeze drying), and the scaffold possesses interconnected and hierarchically structured pores including macropores with sizes up to ≈300 μm. The novel PCL 3D scaffold is soft and elastic with very high porosity of ≈96.4%, thus it is morphologically/structurally similar to natural extracellular matrix and well suited for cell functions and tissue formation. The in vitro studies reveal that the scaffold can lead to high cell viability; more importantly, it is able to promote more potent BMP2-induced chondrogenic than osteogenic differentiation of mouse bone marrow mesenchymal stem cells. Consistent to the in vitro findings, the in vivo results indicate that the electrospun PCL 3D scaffold acts as a favorable synthetic extracellular matrix for functional bone regeneration through the physiological endochondral ossification process.

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Section: Resultsmentioning

confidence: 99%

Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering

Miszuk

Zhao

et al. 2015

Adv Healthcare Materials

253

193

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“…Besides PLLA and gelatin, also poly-ε-caprolactone (PCL) has been fabricated into nanofibrous scaffolds making use of TIPS [66]. PCL was dissolved in a mixture of dioxane and water (mass ratio 90/10) at 40 • C to prepare a 10 w/v% PCL solution, after which the solution was cooled to different gelation temperatures ranging from −8 to 12 • C. Results revealed that completely different scaffold morphologies were obtained depending on the gelation temperature.…”

Section: Thermally-induced Phase Separationmentioning

confidence: 99%

“…In contrast, at high gelation temperatures (≥8 • C), open microporous structures with solid pore walls were obtained. Besides gelation temperature, also the mass ratio of the solvent mixture was found to play a crucial role as with increasing water amount, the nanofibrous assembly was found to disappear [66]. Very recently, highly porous nanofibrous membranes were also successfully fabricated through low temperature-induced phase separation of a chitosan solution in a tertiary solvent mixture (acetic acid/water/ethanol) [67].…”

Section: Thermally-induced Phase Separationmentioning

confidence: 99%

Fabrication and Plasma Modification of Nanofibrous Tissue Engineering Scaffolds

et al. 2020

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This paper provides a comprehensive overview of nanofibrous structures for tissue engineering purposes and the role of non-thermal plasma technology (NTP) within this field. Special attention is first given to nanofiber fabrication strategies, including thermally-induced phase separation, molecular self-assembly, and electrospinning, highlighting their strengths, weaknesses, and potentials. The review then continues to discuss the biodegradable polyesters typically employed for nanofiber fabrication, while the primary focus lies on their applicability and limitations. From thereon, the reader is introduced to the concept of NTP and its application in plasma-assisted surface modification of nanofibrous scaffolds. The final part of the review discusses the available literature on NTP-modified nanofibers looking at the impact of plasma activation and polymerization treatments on nanofiber wettability, surface chemistry, cell adhesion/proliferation and protein grafting. As such, this review provides a complete introduction into NTP-modified nanofibers, while aiming to address the current unexplored potentials left within the field.

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“…Another method used to generate cardiac patches is thermally induced phase separation. With this technique it is possible to create well‐defined interconnected micropores utilizing simple equipment . To improve cardiac remodeling, polyester urethane urea (PEUU) has been processed into patches using phase separation techniques .…”

Section: Biomaterials Used For Myocardial Repairmentioning

confidence: 99%

Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine

Hinderer

Brauchle

Schenke‐Layland

2015

Adv Healthcare Materials

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Current clinically applicable tissue and organ replacement therapies are limited in the field of cardiovascular regenerative medicine. The available options do not regenerate damaged tissues and organs, and, in the majority of the cases, show insufficient restoration of tissue function. To date, anticoagulant drug‐free heart valve replacements or growing valves for pediatric patients, hemocompatible and thrombus‐free vascular substitutes that are smaller than 6 mm, and stem cell‐recruiting delivery systems that induce myocardial regeneration are still only visions of researchers and medical professionals worldwide and far from being the standard of clinical treatment. The design of functional off‐the‐shelf biomaterials as well as automatable and up‐scalable biomaterial processing methods are the focus of current research endeavors and of great interest for fields of tissue engineering and regenerative medicine. Here, various approaches that aim to overcome the current limitations are reviewed, focusing on biomaterials design and generation methods for myocardium, heart valves, and blood vessels. Furthermore, novel contact‐ and marker‐free biomaterial and extracellular matrix assessment methods are highlighted.

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Fabrication of polycaprolactone nanofibrous scaffolds by facile phase separation approach

Cited by 41 publications

References 28 publications

Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering

Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering

Fabrication and Plasma Modification of Nanofibrous Tissue Engineering Scaffolds

Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine

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