Fabrication of porous micro-nanostructured networks on Ti6Al4V for faster hydroxyapatite deposition in SBF

Ge, Yuran; Wu, Meng; Wang, Tao; Guo, Shengda

doi:10.1016/j.matlet.2019.126571

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…The deposition of HAp on PLGA drastically changed scaffold microstructure, as pore surface became rougher. At higher magnification ( Figure 1 c, insert) cauliflower-like structures, typical for low-crystalline hydroxyapatite, can be observed [ 23 ]. The presence of HAp was also confirmed by EDX ( Figure 1 f) and XPS ( Table 1 ) analyses.…”

Section: Resultsmentioning

confidence: 99%

“…The Ca/P atomic ratio was close to 1.66, thus characteristic for hydroxyapatite. The crystalline structure of HAp was also evidenced by X-ray diffractometry (XRD) ( Figure 2 a), as peaks characteristic for HAp appeared at 2θ around 26° (corresponding to 002 plane), 32° (211 plane), and 40° (310 plane) [ 23 , 24 ]. Fourier transform infrared (FTIR) spectra ( Figure 2 b) also confirmed the presence of HAp coating on PLGA scaffold (intensive bands originating from PO 4 3− group at 600 cm −1 and at 1000–1100 cm −1 ) [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

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Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Krok-Borkowicz

Reczyńska

Rumian

et al. 2020

IJMS

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Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leaching method. Their total porosity was 85% and the pore size was in the range of 250–320 µm. The physico-chemical properties of the scaffolds were evaluated using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), sessile drop, and compression tests. Three types of the scaffolds (unmodified PLGA, PLGA/coll, and PLGA/HAp) were implanted into the defects created in New Zealand rabbit femoral trochlears; empty defect acted as control. Samples were extracted after 1, 4, 12, and 26 weeks from the implantation, evaluated using micro-computed tomography (µCT), and stained by Masson–Goldner and hematoxylin-eosin. The results showed that the proposed method is suitable for fabrication of highly porous PLGA scaffolds. Effective deposition of both coll and HAp was confirmed on all surfaces of the pores through the entire scaffold volume. In the in vivo model, PLGA and PLGA/HAp scaffolds enhanced tissue ingrowth as shown by histological and morphometric analyses. Bone formation was the highest for PLGA/HAp scaffolds as evidenced by µCT. Neo-tissue formation in the defect site was well correlated with degradation kinetics of the scaffold material. Interestingly, around PLGA/coll extensive inflammation and inhibited tissue healing were detected, presumably due to immunological response of the host towards collagen of bovine origin. To summarize, PLGA scaffolds modified with HAp are the most promising materials for bone tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Krok-Borkowicz

Reczyńska

Rumian

et al. 2020

IJMS

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“…The water droplet was found to adhere and pin to this micro/nanohierarchically structured surface, the CA of which was as low as 1.2°, as depicted by Figure k. The transformation of superhydrophilicity can be ascribed to the construction of hierarchical structures and the formation of plentiful hydrogen bonds on the sample surface . The roughness sharply increased from 0.096 μm (Figure e) to 4.453 μm (Figure g) after preparing the two-tier structures on the sample surface.…”

Section: Resultsmentioning

confidence: 92%

“…The transformation of superhydrophilicity can be ascribed to the construction of hierarchical structures and the formation of plentiful hydrogen bonds on the sample surface. 21 The roughness sharply increased from 0.096 μm (Figure 2e) to 4.453 μm (Figure 2g) after preparing the two-tier structures on the sample surface. It is generally accepted that surface topography is also an important factor for superhydrophobicity.…”

Section: ■ Introductionmentioning

confidence: 96%

Durable Biomimetic Two-Tier Structured Superhydrophobic Surface with Ultralow Adhesion and Effective Antipollution Property

Zhang

Wang

2023

Langmuir

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Superhydrophobic surfaces with low adhesion have attracted great attention in recent years owing to their extensive applications. Enlightened by multifunctional rice leaves, a micro/nanobinary structured superhydrophobic surface was successfully fabricated on the Ti6Al4V substrate by photoetching, acid etching, alkaline etching, as well as fluorination treatments. Water droplets exhibited a Cassie impregnating wetting state on this superhydrophobic surface, under which the contact area fraction of the liquid-air interface caused by primary micron-scale stripped bumps (f p ) and secondary nanoflower-like structures (f s ) were calculated for the first time. The water adhesion force of this nonwetting surface was precisely measured as 7 μN, which was much lower than that (362 μN) of the original flat substrate and the previous reported surfaces. Moreover, this low-adhesive surface displayed good chemical stability after exposing to air, soaking in aqueous solutions (acid, alkaline, and salt), and cyclic icing/melting treatment. It also showed good mechanical durability after a series of abrasion treatments. Besides, this multifunctional superhydrophobic surface exhibited superior antipollution property to different kinds of contaminants. This multifunctional superhydrophobic surface displays a huge potential for industrial droplet transportation and self-cleaning applications.

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“…The analysis of the XRD patterns of studied samples revealed that the intensity of peaks assigned to HA layers was the greatest. Moreover, all produced hydroxyapatite layers showed superhydrophilic properties, which is highly desirable for biomedical applications [ 23 , 58 , 59 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Cathodic Electrodeposition Effectiveness of the Hydroxyapatite Layer Used in Surface Modification of Ti6Al4V-Based Biomaterials

et al. 2022

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The important issue associated with the design and the fabrication of the titanium and titanium alloy implants is the increase of their biointegration with bone tissue. In the presented paper, the research results concerning the conditions used in the cathodic deposition of hydroxyapatite on the surface Ti6Al4V substrates primarily modified by the production of TiO2 nanoporous coatings, TiO2 nanofibers, and titanate coatings, are discussed. Despite excellent biocompatibility with natural bone tissue of materials based on hydroxyapatite (HA), their poor adhesion to the substrate caused the limited use in the implants’ construction. In our works, we have focused on the comparison of the structure, physicochemical, and mechanical properties of coating systems produced at different conditions. For this purpose, scanning electron microscopy images, chemical composition, X-ray diffraction patterns, infrared spectroscopy, wettability, and mechanical properties are analyzed. Our investigations proved that the intermediate titanium oxide coatings presence significantly increases the adhesion between the hydroxyapatite layer and the Ti6Al4V substrate, thus solving the temporary delamination problems of the HA layer.

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Fabrication of porous micro-nanostructured networks on Ti6Al4V for faster hydroxyapatite deposition in SBF

Cited by 12 publications

References 13 publications

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Durable Biomimetic Two-Tier Structured Superhydrophobic Surface with Ultralow Adhesion and Effective Antipollution Property

Evaluation of the Cathodic Electrodeposition Effectiveness of the Hydroxyapatite Layer Used in Surface Modification of Ti6Al4V-Based Biomaterials

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