Fabrication of Porous n-HA/PA66 Composite for Bone Repair

Li, Hong; Li, Yu Bao; Yan, Yong; Li, Ji Dong; Yang, Aiping; Xiang, Hong

doi:10.4028/0-87849-422-7.321

Cited by 4 publications

(6 citation statements)

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“…Compared to injection molding HA/PA [18], the pores in the materials prepared by the hot-press molding are irregular tubular, the connectivity of which is good. The shape and connectivity of the pores in the biomaterials have important effects on their biological activities in vitro and in vivo [21]. The irregular tubular biomaterial provide good interface between n-HA/PA 66 and host bone; new bone tissue can survive in the pores.…”

Section: Discussionmentioning

confidence: 99%

“…The n-HA/PA66 biocomposite was prepared by thermal-press molding. The material presented: (1) high compressive strength which reached 13∼46 MPa and (2) excellent porous structure; the average diameter of pores in the matrix was in range of 280 m to 500 m and porosity of 36% to 57% ( Figure 1) [21]. The columnar n-HA/PA blocks (height 10 mm and diameter 5 mm) were made by Sichuan National Nano Technology Co., Ltd. (Chengdu, China) ( Figure 2).…”

Section: Methodsmentioning

confidence: 99%

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Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion

Wang

et al. 2014

International Journal of Polymer Science

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This study was conducted to validate the safety and efficiency of biomimetic nanohydroxyapatite/polyamide 66 (n-HA/PA66) composite in animal model (rabbit) and report its application in anterior cervical discectomy and fusion (ACDF) for 4, 12, and 24 weeks. N-HA/PA66 composite was implanted into one-side hind femur defects and the control defects were kept empty as blank controls. A combination of macroscopic and histomorphometric studies was performed up to 24 weeks postoperatively and compared with normal healing. 60 cervical spondylosis myelopathy and radiculopathy patients who were subjected to ACDF using n-HA/PA66 and PEEK cage were involved in this study with six-month minimum follow-up. Their radiographic (cage subsidence, fusion status, and segmental sagittal alignment (SSA)) and clinical (VAS and JOA scales) data before surgery and at each follow-up were recorded and compared. Nanohydroxyapatite/polyamide 66 composite is safe and effective in animal experiment and ACDF.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion

Wang

et al. 2014

International Journal of Polymer Science

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“…[7][8][9] To evaluate the biological safety of the porous n-HA/PA66 composite, a cytotoxicity test, sensitivity test, pyrogen test, and a hemolysis test were carried out according to the Chinese Guo Biao and Tolerancing (GB/T)16886 and GB/T16175. 11 The extract liquid of the porous n-HA/PA66 composite was prepared in biological safety experiments. A mouse fibroblast L929 cell strain, which was inoculated into cell culture dish, was prepared for the cytotoxicity test.…”

Section: Biological Safety Experimentsmentioning

confidence: 99%

Analyzing the behavior of a porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite for healing of bone defects

Xiong

Ren

Zhang

et al. 2014

IJN

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The aim of this study was to analyze the behavior of the porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite grafted for bone defect repair through a series of biological safety experiments, animal experiments, and a more than 5-year long clinical follow-up. The biological safety experiments, carried out in accordance with the Chinese Guo Biao and Tolerancing (GB/T)16886 and GB/T16175, revealed that porous n-HA/PA66 composite had no cytotoxicity, no sensitization effect, no pyrogenic reaction, and that its hemolysis rate was 0.59% (less than 5%). Rabbit models of tibia defects with grafted porous n-HA/PA66 composite were established. After 2 weeks, the experiment showed that osteogenesis was detected in the porous n-HA/PA66 composite; the density of new bone formation was similar to the surrounding host bone at 12 weeks. After 26 weeks, the artificial bone rebuilt to lamellar bone completely. In the clinical study, a retrospective review was carried out for 21 patients who underwent serial radiographic assessment after treatment with porous n-HA/PA66 composite grafts following bone tumor resection. All wounds healed to grade A. No postoperative infections, delayed deep infection, nonspecific inflammation, rejection, or fractures were encountered. At a mean follow-up of 5.3 years, the mean Musculoskeletal Tumor Society’s (MSTS) 93 score was 29.3 points (range: 28–30 points) and mean radiopaque density ratio was 0.77±0.10. The radiologic analysis showed that porous n-HA/PA66 composite had been completely incorporated with the host bone about 1.5 years later. In conclusion, this study indicated that the porous n-HA/PA66 composite had biological safety, and good biocompatibility, osteoinduction, and osseointegration. Thus, the porous n-HA/PA66 composite is an ideal artificial bone substitute and worthy of promotion in the field.

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“…For biomedical application, nano-hydroxyapatite [HA, Ca 10 (PO 4 ) 6 (OH) 2 ] has been developed in a variety of forms used as hard-tissue substitutes and regenerations because of its excellent bioactivity and osteoconductivity as well as with similar composition and crystal structure to natural bone [1][2][3]. However, its applications are dramatically limited for it is highly brittle [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, its applications are dramatically limited for it is highly brittle [2]. A composite of the combined a polymer and n-HA possesses both the osteoconductivity and bioactivity of n-HA and the strength and shape availability of a polymer, that has a potential use in load-bearing repairs [4].…”

Section: Introductionmentioning

confidence: 99%

Study on the fabrication and characterization of a novel n-HA/mulit-(animo acid) compolymer Composite

Nan

et al. 2010

2010 3rd International Nanoelectronics Conference (INEC)

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A novel nano-hydroxyapatite/multi-(amino acid) copolymer (n-HA/MACP) composite was prepared by in situ polymerization and characterized by FT-IR XRD, mechanical measurement, in vitro degradation experiments and cell growth behavior. FT-IR and XRD results showed that the composite was composed of n-HA and an amide linkage structure and hydrogen bond was formed between n-HA and the copolymer. The composite showed different compressive strength of 176-263MPa, varying with the n-HA content in it. A 24-week incubation in phosphate buffered saline exhibited that the composite was degradable with the weight loss of 20.7wt% and the degradation showed no significant effects on the pH of the soaking medium.

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Fabrication of Porous n-HA/PA66 Composite for Bone Repair

Cited by 4 publications

References 0 publications

Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion

Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion

Analyzing the behavior of a porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite for healing of bone defects

Study on the fabrication and characterization of a novel n-HA/mulit-(animo acid) compolymer Composite

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