Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition

Xiong, Zhuo; Yan, Yonggang; Wang, Shenguo; Zhang, Renji; Zhang, Chao

doi:10.1016/s1359-6462(02)00071-4

Cited by 271 publications

(157 citation statements)

References 8 publications

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“…In the case of PLA, processing with the already mentioned 3D printing tool allows obtaining highly precise structures with better resolution than the ones obtained with other currently used methods. 6,7 This improvement in resolution is due to a particular interplay between a set of temperature/plastiziser/printing parameters and the post-processing shrinkage of the struts due to solvent evaporation that using the nozzle-deposition-based system (Tissue Engineering 3-Dn-300, Sciperio/ nScrypt Inc., available in the Rapid Prototyping service of the Biomedical Networking Center, CIBER-BBN, and IBEC www.ibecbarcelona.eu/biomaterials). Homogeneous polymer and polymer/ glass solutions in chloroform (5% w/v) were prepared and printed at 3mm/s and a pressure between 40-80 psi, through a G27 (200 μm) nozzle.…”

Section: Importance Of Materials In 3d Printingmentioning

confidence: 99%

3D printed PLA-based scaffolds

et al. 2013

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Section: Importance Of Materials In 3d Printingmentioning

confidence: 99%

3D printed PLA-based scaffolds

et al. 2013

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“…Scaffolds with high porosity and desirable mechanical properties for bone implants have been developed by many research groups with varying success [10][11][12][13][14][15]. One new method developed to produce highly oriented, microstructures with varying porosity is freeze-casting.…”

Section: Introductionmentioning

confidence: 99%

Potential Bone Replacement Materials Prepared by Two Methods

et al. 2012

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Natural and synthetic hydroxyapatite (HA) scaffolds for potential load-bearing bone implants were fabricated by two methods. The natural scaffolds were formed by heating bovine cancellous bone at 1325°C, which removed the organic and sintered the HA. The synthetic scaffolds were prepared by freeze-casting HA powders, using different solid loadings (20-35 vol.%) and cooling rates (1-10°C/min). Both types of scaffolds were infiltrated with polymethylmethacrylate (PMMA). The porosity, pore size, and compressive mechanical properties of the natural and synthetic scaffolds were investigated and compared to that of natural cortical and cancellous bone. Prior to infiltration, the sintered cancellous scaffolds exhibited pore sizes of 100 -300 µm, a strength of 0.4 -9.7 MPa, and a Young's modulus of 0.1 -1.2 GPa. The freeze-casted scaffolds had pore sizes of 10 -50 µm, strengths of 0.7 -95

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“…(1) To overcome such problems, previous studies (Greulich et al, 1995;Landers and Mülhaupt, 2000;Xiong et al, 2002;Wang et al, 2004;Woodfield et al, 2004;Narayan, 2014) developed a series of nozzle-based RP techniques based on FDM (Fig. 6).…”

Section: Fused Deposition Modelingmentioning

confidence: 99%

Rapid prototyping technology and its application in bone tissue engineering

Yuan

Zhou

Chen

2017

J. Zhejiang Univ. Sci. B

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Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

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Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition

Cited by 271 publications

References 8 publications

3D printed PLA-based scaffolds

3D printed PLA-based scaffolds

Potential Bone Replacement Materials Prepared by Two Methods

Rapid prototyping technology and its application in bone tissue engineering

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