Fabrication of Silicon-Vacancy Color Centers in Nanodiamonds by using Si-Ion Implantation

Kim, Hyeongkwon; Kim, Hye-Yeon; Lee, Jae Yong; Lim, Weon Cheol; Eliades, J.; Kim, Joonkon; Song, Joong-Ho; Suk, Jaekwon

doi:10.3938/jkps.73.661

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Other nanocomplexes involving NDs, including those containing the anticancer drug doxorubicin (DOX) and/or various small interfering RNAs (siRNAs) have been generated and shown to display intense red fluorescence inside cells, again as confirmed via confocal laser scanning microscopy [37,[62][63][64][65][66]. Kim et al used an Si-ion implantation method to fabricate silicon-vacancy color centers in nanodiamonds [67]. In this process, not only the silicon vacancy (SiV) color center is generated, but also the size of NDs is reduced from 50 to 10 nm.…”

Section: The Structure and Properties Of Nanodiamondsmentioning

confidence: 99%

Nanodiamond in cancer theranostics

Zhu

Zhang

et al. 2023

Nano TransMed

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Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles since they offer a single platform that possesses multiple important properties. These include a simple mechanism of synthesis, small size, chemical inertness, a variety of available surface functional groups, good biocompatibility, stable fluorescence, and a long fluorescence lifetime. The use of NDs to deliver anticancer drugs has been an important ND application since NDs can increase chemosensitivity, sustain drug release, and minimize drug side effects. These unique properties have stimulated the application of NDs to cancer imaging and therapy. In this review, we offer a brief introduction of ND structure and their functional properties. This is followed by a summary of recent uses of NDs for imaging purposes, including fluorescent imaging, magnetic resonance imaging (MRI), and other imaging technologies. Special concern is given to studies focusing on NDs use for anticancer drug delivery, anticancer gene delivery, photothermal and photodynamic therapies, and multifunctional combination therapy. We then discuss ND biocompatibility and toxicity in various cells and animal models. Finally, we also discuss the main problems to be solved by future research before NDs can be put to clinical use. The purpose of this review is to provide a side-by-side comparison of studies reporting ND-mediated cancer imaging therapy so that readers can assess the potential clinical applications of ND and have the background necessary to understand the clinical test results associated with ND-related therapy in animals and humans.

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Section: The Structure and Properties Of Nanodiamondsmentioning

confidence: 99%

Nanodiamond in cancer theranostics

Zhu

Zhang

et al. 2023

Nano TransMed

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“…Many non-carbon elements have been incorporated into diamonds to create doped diamond particles [29]. For example, 32 P, Fe and Si can be integrated into the lattice using highly defined ion implantation to impart radiation activity [30], magnetic property [31] and luminescence [32], respectively. The nitrogen-related fluorescence in diamond particles is summarised in Table 1.…”

Section: Types Of Diamonds and Impurity Defectsmentioning

confidence: 99%

“…Single Si-V centres in diamond can be created by ion implantation [32]. These defects act as stable single photon sources and emit a strong and stable fluorescence after excitation in the visible red-green region.…”

Section: Surface Coating Of Ndsmentioning

confidence: 99%

Surface engineering and applications of nanodiamonds in cancer treatment and imaging

Lai

Stenzel

Xiao

2020

International Materials Reviews

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Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles because they unite a spectrum of important properties into a single agent, including facile synthesis, small size, inertness, rich surface functional groups, biocompatibility, stable fluorescence and long fluorescence lifetime. These unique properties have stimulated the application of NDs in cancer treament and imaging. The majority of these applications rely on the rational engineering of the particle surface, as the surface plays a critical role in carrying bioactive molecules, resisting aggregation and constructing composite materials. In this review, recent developments of functionalising NDs for cancer treatment and imaging purposes are discussed. A brief introduction in the structure of NDs and properties of NDs will be given, followed by a summary of various surface functionalisation methods. The latter part is organised in three subsections: NDs coated with bioactive compounds, NDs coated with synthetic polymers and NDs/inorganic composites.

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“…Centra te charakteryzują się silną absorpcją światła o długości fali 550 nm oraz stabilną emisją fluorescencji [95]. Ze względu na wysoki wskaźnik fotostabilności, pod uwagę brane jest również obrazowanie z użyciem NDs, których centra zawierają krzem lub lantanowiec, europ [96,97]. Sztuczne wytworzenie centrów barwnych uzyskuje się najczęściej poprzez napromieniowanie NDs wiązką wysokoenergetycznych elektronów, protonów, jonów helu lub promieni gamma, wykorzystując różnego rodzaju akceleratory [98].…”

Section: Wykorzystanie Nanodiamentów W Bioobrazowaniuunclassified

Nanodiamenty: unikalne nanocząsteczki do zastosowania w biomedycynie i biotechnologii

Nowicki

Czarniewska

2020

Postepy Biochem

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Nanodiamenty to bardzo drobne cząstki diamentu, które ze względu na swój rozmiar w skali nano, unikalne właściwości fizykochemiczne oraz duży stosunek łatwo modyfikowalnej chemicznie powierzchni do objętości są interesujące dla biologów, chemików i fizyków. Praca ta stanowi przegląd literatury na temat ich przygotowania, właściwości i perspektyw związanych z możliwością ich zastosowania w naukach biomedycznych. Wysoka biokompatybilność nanodiamentów, potwierdzona przez szereg badań in vivo i in vitro, odróżnia je od innych nanocząstek i pozwala na ich zastosowanie jako neutralnego systemu transportu związków biologicznie czynnych. Takie nanocząstki można stosować jako nośniki peptydów, białek, kwasów nukleinowych, leków lub innych syntetycznych związków, które spowodują zamierzony efekt biologiczny w organizmie, w bioobrazowaniu i inżynierii tkankowej. Obiecujące wyniki badań na różnych modelach biologicznych sugerują praktyczne zastosowania rozwiązań nanotechnologicznych opartych na nanodiamentach.

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Fabrication of Silicon-Vacancy Color Centers in Nanodiamonds by using Si-Ion Implantation

Cited by 9 publications

References 24 publications

Nanodiamond in cancer theranostics

Nanodiamond in cancer theranostics

Surface engineering and applications of nanodiamonds in cancer treatment and imaging

Nanodiamenty: unikalne nanocząsteczki do zastosowania w biomedycynie i biotechnologii

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