Fabrication of silk fibroin film enhanced by acid hydrolyzed silk fibroin nanowhiskers to improve bacterial inhibition and biocompatibility efficacy

Lin, Minjie; Xie, Wenjiao; Cheng, Xiuwen; Yang, Yuncong; Sonamuthu, Jegatheeswaran; Yang, Xiaogang; Cai, Yurong

doi:10.1080/09205063.2022.2051694

Cited by 6 publications

(5 citation statements)

References 44 publications

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“…However, a longer duration of acid hydrolysis results in a silk fibroin solution. 44 In the next step, the silk microfibers are mechanically chopped in an aqueous solution to obtain a uniform silk nanofibrous dispersion (see Figure 1d). Here, the unique amalgamation of acid hydrolysis and mechanical chopping is crucial to synthesize SNN.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The mechanical chopping of degummed silk produces microfibers of dimensions 8 μm, which is unsuitable for capturing PM 0.3 particles . Conventional acid hydrolysis readily produces silk fibroin solution incompatible with face mask fabrication. , In this context, we have developed simple acid hydrolysis and mechanical chopping to fabricate the SNN for PM 0.3 filters. First, Bombyx mori cocoons were sliced into fine pieces and degummed to remove the sericin protein for extracting pure silk (see Figure a,b) .…”

Section: Resultsmentioning

confidence: 99%

“…The controlled acid hydrolysis is performed on degummed silk for 30 min to accomplish silk microfibers (Figure c). However, a longer duration of acid hydrolysis results in a silk fibroin solution . In the next step, the silk microfibers are mechanically chopped in an aqueous solution to obtain a uniform silk nanofibrous dispersion (see Figure d).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating

Hossain,

Karmakar,

Sarkar

et al. 2024

ACS Omega

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In the contemporary way of life, face masks are crucial in managing disease transmission and battling air pollution. However, two key challenges, self-sanitization and biodegradation of face masks, need immediate attention, prompting the development of innovative solutions for the future. In this study, we present a novel approach that combines controlled acid hydrolysis and mechanical chopping to synthesize a silk nanofibrous network (SNN) seamlessly integrated with a wearable stainless steel mesh, resulting in the fabrication of self-sanitizable face masks. The distinct architecture of face masks showcases remarkable filtration efficiencies of 91.4, 95.4, and 98.3% for PM 0.3 , PM 0.5 , and PM 1.0 , respectively, while maintaining a comfortable level of breathability (ΔP = 92 Pa). Additionally, the face mask shows that a remarkable thermal resistance of 472 °C cm 2 W −1 generates heat spontaneously at low voltage, deactivating Escherichia coli bacteria on the SNN, enabling self-sanitization. The SNN exhibited complete disintegration within the environment in just 10 days, highlighting the remarkable biodegradability of the face mask. The unique advantage of self-sanitization and biodegradation in a face mask filter is simultaneously achieved for the first time, which will open avenues to accomplish environmentally benign nextgeneration face masks.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating

Hossain,

Karmakar,

Sarkar

et al. 2024

ACS Omega

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“…The silk nanofibers have excellent stability at either acidic (pH = 3) or alkali (pH ≥ 7) conditions, which can be fully blended with polymers in different pH environments to prepare new advanced composite materials [89]. Sulfuric acid can also be used to prepare silk protein nanowhisker suspensions, which can be used to strengthen the RSF (extracted by 9.3 M LiBr) material films [90].…”

Section: Sf Degummingmentioning

confidence: 99%

Advances in Preparation and Properties of Regenerated Silk Fibroin

Huang,

Shi,

Zhou

et al. 2023

IJMS

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Over the years, silk fibroin (SF) has gained significant attention in various fields, such as biomedicine, tissue engineering, food processing, photochemistry, and biosensing, owing to its remarkable biocompatibility, machinability, and chemical modifiability. The process of obtaining regenerated silk fibroin (RSF) involves degumming, dissolving, dialysis, and centrifugation. RSF can be further fabricated into films, sponges, microspheres, gels, nanofibers, and other forms. It is now understood that the dissolution method selected greatly impacts the molecular weight distribution and structure of RSF, consequently influencing its subsequent processing and application. This study comprehensively explores and summarizes different dissolution methods of SF while examining their effects on the structure and performance of RSF. The findings presented herein aim to provide valuable insights and references for researchers and practitioners interested in utilizing RSF in diverse fields.

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“…In conclusion, the modification of SF is necessary to improve its performance as well as be endowed with some above special functions. [7][8][9] The modified SF obtained by physical modification [10,11] and chemical modification [12,13] can effectively solve the above problems, and can be further spun into the modified SF fibers by dry spinning, wet spinning, electrospinning or microfluid spinning to be used in filtration, sensors, triboelectric nanogenerators, and tissue engineering, as shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Progress in Research and Application of Modified Silk Fibroin Fibers

Chai,

Wu,

Peng

et al. 2023

Adv Materials Technologies

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Silk fibroin (SF) is a biodegradable protein and possesses superior skin‐friendliness, biocompatibility, low immunogenicity, and non‐toxicity. However, SF has a series of drawbacks. For example, the application of SF in water filtration is limited by its inadequate ability to adsorb heavy metal ions. It is not inherently antibacterial, making SF ineffective as a filter to eliminate airborne bacteria. SF without conductivity is not suitable for use in sensors and triboelectric nanogenerators. In tissue engineering, deficient mechanical and anti‐inflammatory properties also have an influence on the rate of wound recovery. While physical and chemical modifications will improve its application properties as well as broaden its application areas. This review describes the modification of SF by filling, blending, structural adjustment, post treatment, crosslinking, grafting, and in situ polymerization to provide it with other functional properties. Modified SF fibers prepared by various methods (e.g., wet/dry/microfluidic spinning, electrospinning) are discussed, and they can be used in water/air filtration, chemical/pressure/strain sensors, triboelectric nanogenerators, artificial skin, wound dressings, and tissue scaffolds. Finally, the development trend of the modified SF fibers is prospected. This review has a reference significance on how to use modified SF fibers to improve filtration efficiency, sensor performance, and wound recovery.

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Fabrication of silk fibroin film enhanced by acid hydrolyzed silk fibroin nanowhiskers to improve bacterial inhibition and biocompatibility efficacy

Cited by 6 publications

References 44 publications

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating

Advances in Preparation and Properties of Regenerated Silk Fibroin

Progress in Research and Application of Modified Silk Fibroin Fibers

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Fabrication of silk fibroin film enhanced by acid hydrolyzed silk fibroin nanowhiskers to improve bacterial inhibition and biocompatibility efficacy

Cited by 6 publications

References 44 publications

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM0.3 Filters with In Situ Joule Heating

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM0.3 Filters with In Situ Joule Heating

Advances in Preparation and Properties of Regenerated Silk Fibroin

Progress in Research and Application of Modified Silk Fibroin Fibers

Contact Info

Product

Resources

About

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating

Self-Sanitization in a Silk Nanofibrous Network for Biodegradable PM_0.3 Filters with In Situ Joule Heating