Fabrication of silver nanoparticles employing the cyanobacterium Spirulina platensis and its bactericidal effect against opportunistic nosocomial pathogens of the respiratory tract

Ameen, Fuad; Abdullah, Mahmood M. S.; Al-Homaidan, Ali A.; Al‐Lohedan, Hamad A.; Al-Ghanayem, Abdullah A.; Almansob, Abobakr

doi:10.1016/j.molstruc.2020.128392

Cited by 76 publications

(24 citation statements)

References 58 publications

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“…Thermal stability of Ag NPs has been researched and showed final weight at around 70% at 800˚C with around 60% weight at 600˚C in two separate studies [42,57]. The research on green synthesized Ag/AgCl nanoparticles from Oedera genistifolia plant showed similar 70% weight at 900˚C [58].…”

Section: Plos Onementioning

confidence: 97%

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Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity

et al. 2022

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Nowadays, fungal infections increase, and the demand of novel antifungal agents is constantly rising. In the present study, silver, titanium dioxide, cobalt (II) hydroxide and cobalt (II,III) oxide nanomaterials have been synthesized from Spirulina platensis extract. The synthesis mechanism has been studied using GCMS and FTIR thus confirming the involvement of secondary metabolites, mainly amines. The obtained products have been analysed using XRD, SEM, TGA and zeta potential techniques. The findings revealed average crystallite size of 15.22 nm with 9.72 nm for oval-shaped silver nanoparticles increasing to 26.01 nm and 24.86 nm after calcination and 4.81 nm for spherical-shaped titanium dioxide nanoparticles which decreased to 4.62 nm after calcination. Nanoflake shape has been observed for cobalt hydroxide nanomaterials and for cobalt (II, III) oxide with crystallite size of 3.52 nm and 13.28 nm, respectively. Silver nanoparticles showed the best thermal and water dispersion stability of all the prepared structures. Once subjected to three different Candida species (C. albicans, C. glabrata, and C. krusei) silver nanoparticles and cobalt (II) hydroxide nanomaterials showed strong antifungal activity at 50 μg/mL with minimum inhibitory concentration (MIC) values. After light exposition, MIC values for nanomaterials decreased (to 12.5 μg/mL) for C. krusei and increased (100 μg/mL) for C. albicans and C. glabrata.

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Section: Plos Onementioning

confidence: 97%

“…The important role of proteins present in the S. platensis extract for the synthesis of Ag NPs was investigated by Ameen et al [42]. In addition to polysaccharides from S. platensis extract, Attia et al utilized gamma radiation to synthesize Ag NPs [43].…”

Section: Plos Onementioning

confidence: 99%

Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity

et al. 2022

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“…Nanotechnology manipulating the matter at molecular scale has tremendously revolutionized the field of science 1 . Nanoparticles (NPs) with dimeter between 1–100 nm possess distinguished physicochemical properties over bulk-materials including higher surface area to volume (S/V) ratio, surface energy, and chemical reactivity 2 . Physical or chemical methods of NPs synthesis use harmful toxic substances and high temperatures/pressure which make them environmentally unfriendly and expensive 3 .…”

Section: Introductionmentioning

confidence: 99%

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Sonbol

Ameen

Alyahya

et al. 2021

Sci Rep

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146

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Green synthesized nanoparticles (NPs) have emerged as a new and promising alternative to overcome the drug resistance problem. Peculiar nano-specific features of palladium NPs (Pd-NPs) offer invaluable possibilities for clinical treatment. Due to the development of multi-drug resistance (MDR) in pathogenic bacteria and the prevalence of cancers, use of algae-mediated Pd-NPs could be a prospective substitute. Therefore, Pd-NPs were synthesized by a one-step, cost-effective, and environmentally friendly green method using the extract from a brown alga, Padina boryana (PB-extract), and evaluated for their antibacterial, antibiofilm, and anticancer activities. Pd-NPs were physicochemically characterized for size, shape, morphology, surface area, charge, atomic composition, crystal structure, and capping of Pd-NPs by PB-extract biomolecules by various techniques. The data revealed crystalline Pd-NPs with an average diameter of 8.7 nm, crystal size/structure of 11.16 nm/face-centered cubic, lattice d-spacing of 0.226 nm, 28.31% as atomic percentage, surface area of 16.1 m2/g, hydrodynamic size of 48 nm, and zeta-potential of − 28.7 ± 1.6 mV. Fourier-transform infrared spectroscopy (FT-IR) analysis revealed the role of PB-extract in capping of Pd-NPs by various functional groups such as –OH, C=C, C–O, and C–N from phenols, aliphatic hydrocarbons, aromatic rings, and aliphatic amine. Out of 31, 23 compounds were found involved in biosynthesis by Gas chromatography–mass spectrometry (GC–MS) analysis. Isolated strains were identified as MDR Staphylococcus aureus, Escherichia fergusonii, Acinetobacter pittii, Pseudomonas aeruginosa, Aeromonas enteropelogenes, and Proteus mirabilis and Pd-NPs exhibited strong antibacterial/antibiofilm activities against them with minimum inhibitory concentration (MIC) in the range of 62.5–125 μg/mL. Moreover, cell viability assays showed concentration-dependent anti-proliferation of breast cancer MCF-7 cells. Pd-NPs also enhanced mRNA expression of apoptotic marker genes in the order: p53 (5.5-folds) > bax (3.5-folds) > caspase-3 (3-folds) > caspase-9 (2-folds) at 125 μg/mL. This study suggested the possible role of PB-extract capped Pd-NPs for successful clinical management of MDR pathogens and breast cancer cells.

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“…In some cases, plant enzymes like bromelain and vegetable wastes or their extracts have been used to synthesize AuNPs [ 19 , 20 , 21 ]. Adding to these benefits, metallic nanoparticles, notably AuNPs, synthesized for applications in medicine are known to possess antifungal properties, particularly against pathogens capable of causing respiratory infections [ 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Gold Nanoparticles against Drug-Resistant Nosocomial Fungal Pathogens and Their Extracellular Enzymes: Resistance Profiling towards Established Antifungal Agents

2022

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Drug resistance of filamentous fungi to the commonly used antifungal agents is a major concern in medicine. Therefore, an effective approach to treat several opportunistic fungal infections is the need of the hour. Mentha piperita is used in home remedies to treat different disorders. Isolates of fungi were taken from hospitals in Riyadh, Saudi Arabia, and identified using molecular tools. Amphotericin B, Voriconazole, and Micafungin were applied to screen the resistance of these isolates using both disc and broth microdilution techniques. An aqueous extract of Mentha piperita was utilized to synthesize AuNPs and the nanoparticles were characterized using UV-Vis, FTIR, TEM, EDAX, and XRD. The AuNPs were tested for antifungal activity against the nosocomial fungal pathogens and the activity of extracellular enzymes of such pathogens were analyzed after treatment with AuNPs. We conclude that AuNPs synthesized using Mentha piperita do not possess especially effective antifungal properties against multi-drug resistant Aspergillus species. Five out of eighteen isolates were inhibited by AuNPs. When inhibition was observed, significant alterations in the activity profile of extracellular enzymes of the nosocomial fungi were observed.

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Fabrication of silver nanoparticles employing the cyanobacterium Spirulina platensis and its bactericidal effect against opportunistic nosocomial pathogens of the respiratory tract

Cited by 76 publications

References 58 publications

Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity

Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Efficacy of Gold Nanoparticles against Drug-Resistant Nosocomial Fungal Pathogens and Their Extracellular Enzymes: Resistance Profiling towards Established Antifungal Agents

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