Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Sonbol, Hana; Ameen, Fuad; Alyahya, Sami A.; Almansob, Abobakr; Alwakeel, Suaad S.

doi:10.1038/s41598-021-84794-6

Cited by 146 publications

(39 citation statements)

References 69 publications

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“…63 Based on the presented peaks, the presence of protein and polysaccharide in both tested materials (major peaks) suggested their contribution in the process of Ag ions reduction leading to the formation of J-AgNPs capped with biomolecules that prevent their aggregation. Similar findings were also noted [13,42]. The shift in peaks transmittance of FTIR signals for J-AgNPs concerning plant extracts might be due to probable interactions between functional groups (capping and reducing agents) and NPs or metal ions [43].…”

Section: Discussionsupporting

confidence: 76%

Silver Nanoparticles Formation by Jatropha integerrima and LC/MS-QTOF-Based Metabolite Profiling

et al. 2021

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The broad application of metal nanoparticles in different fields encourages scientists to find alternatives to conventional synthesis methods to reduce negative environmental impacts. Herein, we described a safe method for preparing silver nanoparticles (J-AgNPs) using Jatropha integerrima leaves extract as a reducing agent and further characterize its physiochemical and pharmacological properties to identify its therapeutic potential as a cytotoxic and antimicrobial agent. The biogenic synthesized J-AgNPs were physiochemically characterized by ultraviolet-visible spectroscopy, dynamic light scattering (DLS), transmission electron microscope (TEM), and energy-dispersive X-ray spectroscopy. HPLC-DAD, followed by LC/MS and the Fourier-transform infrared spectroscopy (FTIR), was applied to detect the biomolecules of J. integerrima involved in the fabrication of NPs. Furthermore, J-AgNPs and the ampicillin-nanocomposite conjugate were investigated for their potential antibacterial effects against four clinical isolates. Finally, cytotoxic effects were also investigated against cancer and normal cell lines, and their mechanism was assessed using TEM analysis and confocal laser scanning microscopy (LSM). Ag ions were reduced to spherical J-AgNPs, with a zeta potential of −34.7 mV as well as an average size of 91.2 and 22.8 nm as detected by DLS and TEM, respectively. HPLC GC/MC analysis identified five biomolecules, and FTIR suggested the presence of proteins besides polyphenolic molecules; together, these molecules could be responsible for the reduction and capping processes during NP formation. Additionally, J-AgNPs displayed a strong antibacterial effect, although the ampicillin conjugated form had a very weak antibacterial effect. Furthermore, the NPs caused a reduction in cell viability of all the treated cells by initiating ultrastructural changes and apoptosis, as identified by TEM and LSM analysis. Therefore, J-AgNPs can be formed using the leaf extract from the J. integerrima plant. Furthermore, J-AgNPs may serve as a candidate for further biochemical and pharmacological testing to identify its therapeutic value.

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Section: Discussionsupporting

confidence: 76%

Silver Nanoparticles Formation by Jatropha integerrima and LC/MS-QTOF-Based Metabolite Profiling

et al. 2021

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“…The biogenic materials in NPs formation provide capping agents (ie adsorption of molecules on the surface of NPs), which decides its final morphology and thus prevents the overgrowth of NPs. 80 , 81 Generally, the biosynthesis of AgNPs follows the reduction of Ag + ions to Ag 0 from electrons liberated mainly from the biogenic agent’s active biomolecules that finally cap the formed NPs. Currently, the color of AgNO 3 when mixed with each Phoma sp., Chaetomium globosum , and Chaetomium sp.…”

Section: Discussionmentioning

confidence: 99%

Soil Fungi as Biomediator in Silver Nanoparticles Formation and Antimicrobial Efficacy

Sonbol¹,

Mohammed²,

Korany³

2022

IJN

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Introduction and Objectives: Biogenic agents in nanoparticles fabrication are gaining great interest due to their lower possible negative environmental impacts. The present study aimed to isolate fungal strains from deserts in Saudi Arabia and assess their ability in silver nanoparticles (AgNPs) fabrication and evaluate their antibacterial effect. Methods: Soil fungi were identified using 18s rDNA, and their ability in NPs fabrication was assessed as extracellular synthesis, then UV-vis spectroscopy, dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy, and transmission electron microscopy were used for AgNPs characterization. The antibacterial activity of fungal-based NPs was assessed against one Gram-positive methicillin-resistant S. aureus (MRSA) and three Gram-negative bacteria (E. coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae). Ultrastructural changes caused by fungal-based NPs on K. pneumoniae were investigated using TEM along with SDS-PAGE for protein profile patterns. Results: The three fungal isolates were identified as Phoma sp. (MN995524), Chaetomium globosum (MN995493), and Chaetomium sp. (MN995550), and their filtrate reduced Ag ions into spherical P-AgNPs, G-AgNPs, and C-AgNPs, respectively. DLS data showed an average size between 12.26 and 70.24 nm, where EDX spectrums represent Ag at 3.0 keV peak. G-AgNPs displayed strong antibacterial activities against Klebsiella pneumoniae, and the ultrastructural changes caused by NPs were noted. Additionally, SDS-PAGE analysis of treated K. pneumoniae revealed fewer bands compared to control, which could be related to protein degradation. Conclusion: Present findings have consequently developed an eco-friendly approach in NPs formation by environmentally isolated fungal strains to yield NPs as antibacterial agents.

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“…Moreover, recent papers revealed that Pd nanoparticles obtained through a plantmediated biogenic approach are less toxic and biocompatible [33] and present important activity as an antioxidant, anticancer, antimicrobial and antiproliferative [9,10,12,[34][35][36][37][38][39][40][41][42][43][44], and can be used for environmental remediation [45]. Recent examples of the green synthesis of Pd nanoparticles mediated by plant extracts and their application as catalysts are shown in the Table 1.…”

Section: Plant Extractsmentioning

confidence: 99%

Green Synthesis of Pd Nanoparticles for Sustainable and Environmentally Benign Processes

Piermatti

2021

Catalysts

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Among transition metal nanoparticles, palladium nanoparticles (PdNPs) are recognized for their high catalytic activity in a wide range of organic transformations that are of academic and industrial importance. The increased interest in environmental issues has led to the development of various green approaches for the preparation of efficient, low-cost and environmentally sustainable Pd-nanocatalysts. Environmentally friendly solvents, non-toxic reducing reagents, biodegradable capping and stabilizing agents and energy-efficient synthetic methods are the main aspects that have been taken into account for the production of Pd nanoparticles in a green approach. This review provides an overview of the fundamental approaches used for the green synthesis of PdNPs and their catalytic application in sustainable processes as cross-coupling reactions and reductions with particular attention afforded to the recovery and reuse of the palladium nanocatalyst, from 2015 to the present.

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Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Cited by 146 publications

References 69 publications

Silver Nanoparticles Formation by Jatropha integerrima and LC/MS-QTOF-Based Metabolite Profiling

Silver Nanoparticles Formation by Jatropha integerrima and LC/MS-QTOF-Based Metabolite Profiling

Soil Fungi as Biomediator in Silver Nanoparticles Formation and Antimicrobial Efficacy

Green Synthesis of Pd Nanoparticles for Sustainable and Environmentally Benign Processes

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