Fabrication of Sodium-Substituted Hydroxyapatite Ceramics via Ultrasonic Spray-Pyrolysis Route and their Material Properties

Yokota, Tomohiro; Ito, Rei; Shimizu, Y.; Honda, Michiyo; Aizawa, Mamoru

doi:10.4028/www.scientific.net/kem.758.166

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…In our previous study focused on cation doping, Yokota et al [9,10] fabricated sodium-or potassiumsubstituted HAp. They have also successfully fabricated bone HAp ceramics, including bone minerals with six types of ions; Na + , K + , Mg 2+ , F − , Cl − and CO 3 2− .…”

Section: Introductionmentioning

confidence: 99%

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Development of nitrogen-doped hydroxyapatite ceramics

Kaneko

Suzuki

Umeda

et al. 2020

Journal of Asian Ceramic Societies

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Hydroxyapatite (Ca 10 (PO 4) 6 (OH) 2 ; HAp) is widely used as a biomaterial due to its high biocompatibility. However, biological apatite present in bone and teeth contains various ions in the HAp crystal structure. Thus, biological apatite has many strains and defects, which may impart high osteoconductivity to apatite. To clarify the effects of the strain and/or defects in the HAp crystal structure on the bioactivity, nitrogen-doped (N-doped) HAp ceramics were fabricated by heating pure HAp ceramics. This N-doped method is well-known as a technique to modify the chemical structure at the surface. Some properties of the N-doped HAp ceramics were examined for optimization of the heating temperature. N-doped HAp ceramics fabricated by heating at 850°C in an NH 3 atmosphere had N 2 O molecules in the crystal structure. Therefore, the N-doped HAp ceramics fabricated by the N-doping method have a rare moleculesubstitution structure. In conclusion, we have developed the N-doped HAp ceramics which have a rare molecule-substitution structure.

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Section: Introductionmentioning

confidence: 99%

“…As described above, a number of studies have reported the effects of cations in biological apatite [3][4][5][6][7][8][9][10][11]. An artificially obtained material may have promoted bioactivity by the effect of substituted ions; for example, magnesium ions promote bone formation [14].…”

Section: Introductionmentioning

confidence: 99%

Development of nitrogen-doped hydroxyapatite ceramics

Kaneko

Suzuki

Umeda

et al. 2020

Journal of Asian Ceramic Societies

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“…As compared to HA and Eu:HA NPs at 550 °C, the lattice constants (Supporting Information, Table S3) of the Eu:HA-F- 550 and Cit/Eu:HA-F- 550 NPs decreased in the a -axis direction and increased in the c -axis direction. For the Eu:HA-F- 550 NPs, it was speculated that the Na + and CO 3 2– ions substituted for Ca and PO 4 sites, respectively, so that the a -axis decreased and the c -axis increased . For the Cit/Eu:HA-F- 550 NPs, the OH site was substituted with F – ions to decrease the a -axis, in addition to the same mechanism to the Eu:HA-F- 550 NPs.…”

Section: Resultsmentioning

confidence: 99%

“…For the Eu:HA-F-550 NPs, it was speculated that the Na + and CO 3 2− ions substituted for Ca and PO 4 sites, respectively, so that the a-axis decreased and the c-axis increased. 50 For the Cit/Eu:HA-F-550 NPs, the OH site was substituted with F − ions to decrease the a-axis, 51 in addition to the same mechanism to the Eu:HA-F-550 NPs. S4 (Supporting Information) shows the FE-SEM images of the NPs, suggesting that the aggregates of primary NPs were observed.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Effective Thermal Diffusion of Eu(III) and F Ions into Hydroxyapatite Nanoparticles by Citric Acid Coordinative Mediation

Wanyu

Liu

Yamada

et al. 2023

ACS Appl. Nano Mater.

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We synthesized citric acid (Cit)-coordinated Eu3+ and F– codoped hydroxyapatite (Cit/Eu:HA-F) nanoparticles (NPs) and investigated their ion diffusion processes based on photoluminescence (PL) properties at the near-surfaces with thermal treatment. At 85 °C, the Cit coordination layer effectively suppressed the nonradiative deactivation of HA NP surfaces in the PL process, and the quantum yield (ηint) of Eu3+ ions reached a maximum value of ca. 33%, indicating the highest PL efficiency in the HA system. At 250 °C, Cit was decomposed into aconitic acid with a high optical absorption coefficient and reducing ability, so that the ηint of the Eu ions in the NPs were minimized and the partial Eu3+ ions were resultantly reduced to Eu2+ ions. At around 350 °C, the Eu ions were partially diffused from Ca(I) into Ca(II) sites. At 550 °C, the proportion of Eu ions in Ca(II) sites dramatically reached up to ca. 31%, and the F– ions simultaneously diffused into the HA structures by substituting for the OH sites. Therefore, it was elucidated that the Cit molecules coordinated to the Eu and F– codoped HA surfaces achieved higher ηint and promoted the diffusion of various ions into the HA structures with thermal treatment and resultantly controlled the existence ratio of the Eu3+ and Eu2+ ions at the near surfaces, which could be expected to control the PL color by the Cit coordinative mediation technique and realize the creation of cell-labeling luminescent nanomaterials in biomedical fields.

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“…Various studies suggest that calcium phosphate nanoparticles can be successfully used as a fluorescent probe after doping with lanthanide [ 8 , 9 ]. The main methods used to obtain hydroxyapatite are: Conventional method [ 10 , 11 ], wet chemical synthesis [ 12 ], hydrothermal conversion of calcium carbonate [ 13 , 14 ], bone calcination [ 15 , 16 ], solid phase reactions [ 17 , 18 ], co-precipitation reactions [ 19 , 20 ], sol-gel method [ 21 , 22 , 23 ], biomimetic synthesis [ 24 , 25 ], and pyrolysis [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation

et al. 2021

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Improved compounds of Ce(III) and Ce(IV)-doped hydroxyapatite (Ca10-xCex(PO4)6(OH)2) with different concentrations such as x = 0.5, 1, 2.5, 5, and 10%, obtained by the simple co-precipitation method were synthesized. The cerium (3+) and cerium (4+)-doped hydroxyapatite were evaluated for biocompatibility and fluorescence properties. It was found that the cerium-HAp powders were non-toxic, even at higher level of concentration. The synthesized powders were further characterized by FTIR spectrometry, UV-Vis spectroscopy, XRD diffraction, SEM and TEM analysis. Therefore, the present study proves that the developed cerium (3+) and cerium (4+)-doped hydroxyapatite, respectively can be widely used as luminescent labeling materials, with improved biological properties.

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Fabrication of Sodium-Substituted Hydroxyapatite Ceramics via Ultrasonic Spray-Pyrolysis Route and their Material Properties

Cited by 7 publications

References 19 publications

Development of nitrogen-doped hydroxyapatite ceramics

Development of nitrogen-doped hydroxyapatite ceramics

Effective Thermal Diffusion of Eu(III) and F Ions into Hydroxyapatite Nanoparticles by Citric Acid Coordinative Mediation

Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation

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