Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation

Paduraru, Andrei Viorel; Musuc, Adina Magdalena; Oprea, Ovidiu; Trușcă, Roxana; Iordache, Florin; Vasile, Bogdan Ștefan; Andronescu, Ecaterina

doi:10.3390/nano11081911

Cited by 25 publications

(22 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HAp, a calcium phosphate-based bioceramic, is an extensively used biomaterial for bone substitution [ 1 ]. This is because the HAp system has a similar chemical composition as that of human bones, excellent biocompatibility, and good osteoconductive properties, which make it one of the important implant materials for orthopedic-related treatments [ 2 , 3 ]. The HAp system also shows excellent stability in an aqueous medium above pH 4.3, which is within the range of the pH of human blood [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics

et al. 2021

View full text Add to dashboard Cite

The effect of the sintering temperature on densification and the resultant mechanical, electrical, and biological properties of mechanochemically processed hydroxyapatite (HAp) samples was investigated. HAp samples were sintered at 1200, 1250, and 1300 °C for 4 h, respectively. HAp samples sintered at 1250 °C showed better mechanical properties, which was attributed to their smaller grain size compared to HAp samples at higher sintering temperatures. The nearly identical value of the dielectric constant (εr) and better cell proliferation was exhibited by HAp samples sintered at 1250 and 1300 °C, respectively. At ~210 °C, in all the samples sintered at different temperatures, a dielectric anomaly was obtained, which was attributed to the phase transition temperature of the HAp system. Dielectric properties near the phase transition temperature showed a dielectric relaxation-type of behavior, which was attributed to the re-orientational motion of OH− ions in the HAp system. Higher cell proliferation and viability were exhibited by the HAp1300 samples, whereas comparatively equivalent cell growth and higher mechanical strength were observed in the HAp1250 samples.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The loading of amino-functionalized CQDs could improve the photoluminescence intensity of HAp, as can be seen in Figure 5(a). The maximum emission peak for all samples can be found within the range of 438 to 451 nm, which can be associated with PO 3− 4 /tetrahedral anion or structural defect from oxygen vacancies or interstitial atoms [27,28]. Shoulder peak at around 600 nm can be attributed to defects or impurities such as O 2− ions in the matrix of HAp, which can act as luminescence center [27,29].…”

Section: Optical Propertiesmentioning

confidence: 91%

The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent

Hui¹,

Dhanapalan²,

Khayrani³

et al. 2022

Comptes Rendus. Chimie

View full text Add to dashboard Cite

Hydroxyapatite (HAp) was combined with amino-functionalized carbon quantum dots (CQDs) to enhance the optical and surface area properties of HAp. The loading of aminofunctionalized CQDs could enhance the luminescence of HAp and its UV-Vis absorbance. Additionally, surface area of HAp could be increased from 84.16 to 129.94 m 2 /g by loading aminofunctionalized CQDs. The drug release experiment was conducted using acetaminophen. The release happened slowly for amino-functionalized CQDs/HAp, with full release of acetaminophen being observed after 24 h. The enhanced luminescence composite shows high potential for the composite to be used for the controlled release of drugs.

show abstract

“…Subsequently, 100 µL Luciferin Detection Reagent was added and incubated at 37 °C for an additional time of 15 min. Afterwards, the medium from the wells was well homogenized and then the plate was read on the luminometer (Microplate Luminometer Centro LB 960, Berthold, Germany) [ 32 , 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of Terbium Ions and Their Concentration on the Photoluminescence Properties of Hydroxyapatite for Biomedical Applications

et al. 2021

Self Cite

View full text Add to dashboard Cite

A new generation of biomaterials with terbium-doped hydroxyapatite was obtained using a coprecipitation method. The synthesis of new materials with luminescent properties represents a challenging but important contribution due to their potential applications in biomedical science. The main objective of this study was to revel the influence of terbium ions on the design and structure of hydroxyapatite. Different concentrations of terbium, described by the chemical formula Ca10−xTbx(PO4)6(OH)2, where x is in the range of 0 to 1, were considered. The consequence of ion concentration on hydroxyapatite morphology was also investigated. The morphology and structure, as well as the optical properties, of the obtained nanomaterials were characterized using X-ray powder diffraction analysis (XRD), Fourier Transform Infrared spectrometry (FTIR), SEM and TEM microscopy, UV-Vis and photoluminescence spectroscopies. The measurements revealed that terbium ions were integrated into the structure of hydroxyapatite within certain compositional limits. The biocompatibility and cytotoxicity of the obtained powders evaluated using MTT assay, oxidative stress assessment and fluorescent microscopy revealed the ability of the synthesized nanomaterials to be used for biological system imaging.

show abstract

Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation

Cited by 25 publications

References 57 publications

Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics

Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics

The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent

Influence of Terbium Ions and Their Concentration on the Photoluminescence Properties of Hydroxyapatite for Biomedical Applications

Contact Info

Product

Resources

About