Fabrication of SPR Nanosensor Using Gold Nanoparticles and Self-Assembled Monolayer Technique for Detection of Cu²⁺in an Aqueous Solution

Abstract

In this work, we investigated the fabrication of surface plasmon resonance (SPR) nanosensor using gold nanoparticles (AuNPs) chemisorbed onto self assembled monolayer of 10-(3-amino phenoxy) decane-1-thiol on gold substrate. The fabrication process of SPR nanosensor was characterized using different techniques such as infrared reflection-absorption spectra (IRRAS), xX-ray photoelectron spectroscopy (XPS), and atomic force microscope (AFM). The fabricated SPR nanosensor was used for detection of Cu 2þ in an aqueous solution using surface plasmon resonance refractometer. The results confirm the fabrication of new SPR nanosensor. The fabricated SPR nanosensor showed a good activity toward the detection of Cu 2þ . The detection of Cu 2þ in an aqueous solution using the fabricated SPR nansensor was enhanced in the presence of gold nanoparticles.

A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin

“…Past studies have shown that current SPR methods can detect approximately 100 ng/L proteins [ 16 ], which sensitivity is sometimes insufficient for measuring samples. During recent years, colloidal gold nanoparticles have been widely used as a label for analytical signal amplification [ 17 , 18 ]. They possess advantages such as narrow size distribution, rapid and easy synthesis, efficient surface modification, and desirable biocompatibility [ 19 ].…”