Fabrication of three-dimensional PCL/BiFeO3 scaffolds for biomedical applications

Ulag, Songul; Kalkandelen, Cevriye; Bedir, Tuba; Erdemir, Gökçe; Erdem‐Kuruca, Serap; Dumludağ, Fatih; Üstündağ, Cem Bülent; Rayaman, Erkan; Ekren, Nazmi; Kılıç, Beyhan; Gündüz, Oğuzhan

doi:10.1016/j.mseb.2020.114660

Cited by 18 publications

(19 citation statements)

References 29 publications

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“…Differential scanning calorimetry was used to observe the temperature transitions, and the thermograms of a single endothermic peak were acquired and are demonstrated in Figure 5 . In this study, the melting temperature (T m ) of 25% PCL was observed at 61 °C, near previously reported values [ 32 ]. It was investigated that there was no noticeable difference in T m values between the scaffolds by adding J to the 25% PCL scaffold, and it was discovered that the high concentration of J altered the values slightly due to the high molecular dispersion of the 25% PCL scaffold.…”

Section: Resultssupporting

confidence: 88%

3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering

et al. 2022

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Skin diseases are commonly treated with antihistamines, antibiotics, laser therapy, topical medications, local vitamins, or steroids. Since conventional treatments for wound healing (skin allografts, amnion, xenografts, etc.) have disadvantages such as antigenicity of the donor tissue, risk of infection, or lack of basement membrane, skin tissue engineering has become a popular new approach. The current study presents the design and fabrication of a new wound-dressing material by the addition of Juglone (5-hydroxy-1,4-naphthoquinone) to a 25% Polycaprolactone (PCL) scaffold. Juglone (J) is a significant allelochemical found in walnut trees and, in this study is used as a bioactive material. The effects of different amounts of J (1.25, 2.5, 5, 7.5, and 10 mg) on the biocompatibility, mechanical, chemical, thermal, morphological, and antimicrobial properties of the 3D-printed 25% PCL scaffolds were investigated. The addition of J increased the pore diameter of the 25% PCL scaffold. The maximum pore size (290.72 ± 14 µm) was observed for the highest amount of J (10 mg). The biocompatibility tests on the scaffolds demonstrated biocompatible behavior from the first day of incubation, the 25% PCL/7.5 J scaffold having the highest viability value (118%) among all of the J-loaded scaffolds. Drug release of J into phosphate buffered saline (PBS) at pH 7.4 showed that J was completely released from all 25% PCL/J scaffolds within 7 days of incubation.

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Section: Resultssupporting

confidence: 88%

3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering

et al. 2022

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“…[29] Therefore, the only limitation related to 3D printing is its unsuitability for large-scale production due to its slow printing rate, which is considered a benefit in precision medicine and compatible therapy, due to which AM is widely accepted in various biomedical applications. [12,[30][31][32] The advancement of AM techniques has offered new solutions driven by robust demands. Several procedures are established depending upon different types of material like polymers and their nanocomposites.…”

Section: Additive Manufacturing Methodsmentioning

confidence: 99%

“…PVDF-TrFE FDM In situ sensors [270] PDMS/BaTiO3 SLA Breathing sensor [285] PVDF/BaTiO3/CNT SLS Smart sensors with shape memory effects [286] Mn-ZnO/PVDF FFF Magnetic sensors [287] (Ionic liquid filament) IL/PVDF FDM Self-polarization characteristics [288] Silver and tellurium nanowires Aerosol jet printing Skin sensors [289] Bismuth ferrite (BiFeO3)/PCL FDM Biomedical Scaffolds [12] Titanate hydroxyapatite Binder jetting Scaffold implants for bone regeneration [26] Regenerated silk (RS)/poly(3-hydroxybutyrateco-3-hydroxyvalerate) (PHBV) FDM Biosensors with self-powering capabilities [290] ZnO/PVDF FDM Biosensors with significant shape memory effects [291] Polydimethylsiloxane (PDMS)/ Pb(Zr,Ti)O3 (PZT) FDM Artificial muscles [292] F I G U R E 1 9 Future possibilities in different polymers.…”

Section: Materials Am Techniques Applications Referencesmentioning

confidence: 99%

“…Consequently, such materials have applications in sensors, [8] robots, [9] complex parts, [10] scaffold implants, [11] and several other biomedical applications. [12][13][14] Smart materials are programmable materials in which the shape and structure are defined in computer-aided design (CAD) modeling software with specified characteristics and sliced with layers having the required thickness for 3DP/4DP. A further advanced level of products made by another type of smart materials would be triggered by applying external stimuli, which can alter the material's particular property, hence the product's shape.…”

Section: Introductionmentioning

confidence: 99%

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Additive manufacturing of smart polymeric composites: Literature review and future perspectives

2022

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The latest developments in smart systems for improved human lives with advanced biomedical devices have evolved out of multi‐disciplinary scientific studies, including medicine, biology, material sciences, design, manufacturing, artificial intelligence, microelectronics, and so forth. The growth of such intelligent systems is primarily possible with innovative materials, which demonstrate the response to various external stimuli like temperature, heat, moisture, light, electromagnetic field, and chemical alteration. Such materials have been recently fabricated using different additive manufacturing techniques to devise personalized unique, complex, and novel structures that can adjust to external conditions over time and are specifically attributed to 4D printing. Novel materials that can further improve such systems continued to be explored and employed. This review paper investigates the additive manufacturing of functional polymer nanocomposites, which offer compliant structures with flexible manufacturing processes with high strength, low cost, and long‐term stability. This study aims to deliver a comprehensive and deep understanding of the latest developments in materials, design, manufacturing, fundamental mechanisms involved, and future possibilities in this area of research.

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“…In our recent study, BFO nanoparticles were added as nanofiller into polycaprolactone (PCL) scaffolds for biomedical applications. The results showed that PCL/BFO composites had greater conductivity values than pristine BFO and exhibited good biocompatibility with adenocarcinoma lung cancer cell line 29 . The superior electrical properties of BFO makes it a potential candidate for use in neural tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Effect of electric stimulus on human adipose‐derived mesenchymal stem cells cultured in 3D‐printed scaffolds

Bedir

Ulag

Aydogan

et al. 2020

Polymers for Advanced Techs

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Electrical stimulation has shown great potential for nerve regeneration processes. This makes it attractive to use electrically active materials in the neural scaffold. In this paper, bismuth ferrite (BFO) nanoparticles were synthesized via co‐precipitation method and incorporated to 10 wt% polylactic acid (PLA) in chloroform to obtain 3D‐printed PLA/BFO biocomposites. The crystallinity of BFO nanoparticles was confirmed by XRD, and we studied its chemical structure with FTIR, as well as the mechanical properties of the 3D‐printed composites. in vitro studies show that 3D‐printed scaffolds have no cytotoxicity and support the proliferation of human adipose‐derived mesenchymal stem cells (hADMSCs). Furthermore, 3D scaffolds embedded with BFO shows the highest cell viability relative to pristine PLA and BFO‐lined PLA scaffolds. A 48 hours electrical stimulation on the hADMSC cultured inside the 3D‐printed BFO‐lined PLA scaffolds indicates that stimulated cells are aligned toward the BFO line. These results could indicate the potential of BFO for directing cells toward damaged tissues.

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Fabrication of three-dimensional PCL/BiFeO3 scaffolds for biomedical applications

Cited by 18 publications

References 29 publications

3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering

3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

Effect of electric stimulus on human adipose‐derived mesenchymal stem cells cultured in 3D‐printed scaffolds

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